this post deserves an ongoing bump as the dangers of combining selegiline can not be overstated.
selegiline is an amazing agent with a broad therapeutic index, varied pharmacological profile and many subtle and not so subtle effects.
as we all know, selegiline is an irreversible MAOB inhibitor. irreversible means your enzyme levels will not be back to normal for at ~ 2 weeks after you stop taking it.
what’s more important to many of you balls-out readers, is it semipermanently hypersensitises you to psychedelics, which is not a good thing. you may go into overdose territory on a subthreshold Erowid dose.
i have extensive experience with combining selegiline, and have posted several times in the past as to the specific dangers of combining it with the 2C-X class. the combo is especially hazardous if you are in the middle of a course, which means your MAO-B is fairly fully suppressed.
MAO-A deaminates primarily serotonin, norepinephrine, dopamine and octopamine, while MAO-B takes care of phenylethylamine, dopamine, benzylamine and methyl-histamine. to paraphrase what Sasha wrote awhile back, many ring-substituted phens are readily deaminated by MAO and the invariably greater potencies of the corresponding phenylisopropylamines (amphetamines) is due to immunity from attack by these enzymes.
this is why selegiline does not pose much of a hazard when combined with amphetamines (and has been shown to be neuroprotective post acute MDMA intoxication), but has such radical and mostly negative effects when combined with 2C phens. when you are taking an irreversible MAOI is you are greatly reducing the metabolic clearance of your psychedelic substrate leading to who knows what, pharmacokinetics-wise.
again, in combining selegiline (l-deprenyl, Eldepryl, Jumex, Davur) and members of the 2C family, any potential benefits that you think might be gained are vastly overshadowed by the negatives.
THE NEGATIVES INCLUDE COMPLETELY UNPREDICTABLE POTENTIATION, SIGNIFICANT CNS AND CARDIOVASCULAR STIMULATION, CRAMPING OF THE EXTREMITIES, IRRATIONAL AND DELUSIONAL THINKING, AS WELL AS YOUR GENERAL PSYCHEDELIC DEATH TRIP FREAKOUTS.
so don’t do it. and if you are foolhardy enough to do so, CUT YOUR 2C DOSE AT LEAST BY 3.
/rant