• The Dark Side 💕 Welcome Guest 💕
    Posting Rules Bluelight Rules
    Notable Threads Urgent Hotlines
    Bereavement Mindfulness
    Suicide Support Anger Management
  • TDS Moderators: AlphaMethylPhenyl | paranoid android

Coming off Invega/Xeplion (paliperidone) injections v11

Status
Not open for further replies.
rawbanana said:
It’s all day for me and the barrage of thoughts are unbearable it’s like layers and layers of pain… I can’t manage the feelings. Feels so heavy I can’t bear it. I want to die just to make it all stop
Click to expand...
They don’t stop. Layers after layers. This medication have fucked me up. I’m done
 
jrturp said:
I thought ability to feel substances comes back?
Click to expand...

They do for most people, and some never lose them. Not losing your ability to feel substances(weed) is the best correlation to recovery we currently have at our disposal.

In plain English, if you never lose your ability to get high. You’re extremely likely to recover.
 
mona21 said:
I just returned to my home country from UK today. My mother doesn’t address the severity of the problems I am going through because of invega. My loss of emotions or anhedonia or sexual dysfunction she addresses none of it , the shit mother she is. She is just concerned that I havent got any periods in last 7 months ( last period on April 11th) and that I gained a lot of weight (15 kgs) . She keeps on blaming and fatshaming me constantly. So, my mother is forcing me to see a gynaecologist and start some hormone medication for withdrawal bleeding and inducing period. Is that safe after invega? I am scared to even take any hormones now. @InvegaAnon did you miss periods in the beginning? When did they return? Did any female take hormones to get back period?
Click to expand...
I got my period back in November 2023 and I became regular again over last summer. I took vaginal estrogen because my clit kept shrinking.

You should get your prolactin tested.
 
InvegaAnon said:
I got my period back in November 2023 and I became regular again over last summer. I took vaginal estrogen because my clit kept shrinking.

You should get your prolactin tested.
Click to expand...
your profile says 85% recovered, what have you recovered and what have you not recovered?
 
twinpeaks123 said:
has anyone noticed their side effects worsened with each dose?
Click to expand...
I noticed this- - each injection made me feel worse each time, but it kind of plateaued after the fourth injection, and then it has maintained this intensity ever since. Even now- - three months off I feel the same. I've been suffering ever since. Apparently its normal for me to feel this way three months off, but even with this knowledge- - that I'm in early stages of recovery I don't think ill get better. It has been the worst time of my life and I don't know if this will end.
 
Am I correct in stating that paliperidone is an active metabolite of the older neuroleptic rispiridone BUT allows for a long-chain ester (palmitate) prodrug to provide a depot formulation?

If so, I am a little surprised as to my untutored eye, that's going to produce an extremely lipophilic prodrug. Haloperidol depot is the n-decanoate (10 carbon) ester whereas the palmitate (16 carbon) will be even more lipophilic.

All other things being equal, that's going to have a tremendously long half life. Now I don't know if other metabolic processes mean that the palmitate doesn't have the same half-life as haloperidol decanoate but I don't know of any such metabolism.

On a different topic, I have known some people who had been prescribed depot injections of various neuroleptics. In every single case, I asked why, after decades, they were STILL being given depot injections since they were also prescribed medications that had to be taken multiple times a day and as far as I know, they didn't struggle to manage those other medications. I'm just asking if, while a depot MAY be appropriate in certain situations, do people feel they needed the depot? Or Are people essentially being told that either they accepted the depot or could end up either sectioned or in breach of a community drug treatment order (CDTO).

Because this thread certainly doesn't read as people being happy with the outcomes.
 
RisperdalConsta50mg said:
Well only time can tell me if i will recover, i have 2 months ahead of me to reach 18 months and 8 months ahead of me to reach 24 months, most people say it took them 18 months to feel “ok” in a certain way and 24 months to feel normal ag
Click to expand...


---

So, while even a very simple virus can kill us, and while so-called medications like antibiotics, painkillers, and blood pressure drugs already have serious side effects, we now know that these fucking antipsychotics and antidepressants they give us are actually poisons that disrupt not only the brain’s chemistry but many different functions of the body. I don’t just think my brain chemistry was disrupted — I think most parts of my brain aren’t even working anymore.

And aside from that, D2 dopamine receptors aren’t only in the brain; they play roles in organs like the kidneys and pancreas. Anyone can look up what functions D2 receptors have and where in the body they’re found. And it’s not just the D2 receptor — they mess with many different receptors. What I’m trying to say is: yes, there is a blocking effect, and those sons of bitches who invented this poison have absolutely no idea what kind of chain reactions, chaos, and disaster they cause in the brain and the body.

After quitting the medications, I realized that this is not some long-lasting flu — the brain is an extremely delicate structure and should never be interfered with. Seeing people born with mental or physical disabilities made me think the body isn’t that perfect after all, and that the whole “plasticity” concept is just nonsense pushed by neuroscience. If the brain were so perfect, people wouldn’t fall into depression or psychosis in the first place, because when you first start taking antidepressants you go like “wow, is this really how people live?” — you get the effect, but at some point the brain can’t regulate it anymore, so either you increase the dose or you go into psychosis.

There are people who are predisposed to depression, and then there are the lucky ones. Both groups should never be exposed to these drugs. I’ve lost faith that I’ll recover in 6 months, and my condition is actually worse than most — not saying this to compare. I’m just saying we’re helpless creatures abandoned in a world God has fucked.


---
 
4DQSAR said:
Am I correct in stating that paliperidone is an active metabolite of the older neuroleptic rispiridone BUT allows for a long-chain ester (palmitate) prodrug to provide a depot formulation?

If so, I am a little surprised as to my untutored eye, that's going to produce an extremely lipophilic prodrug. Haloperidol depot is the n-decanoate (10 carbon) ester whereas the palmitate (16 carbon) will be even more lipophilic.

All other things being equal, that's going to have a tremendously long half life. Now I don't know if other metabolic processes mean that the palmitate doesn't have the same half-life as haloperidol decanoate but I don't know of any such metabolism.

On a different topic, I have known some people who had been prescribed depot injections of various neuroleptics. In every single case, I asked why, after decades, they were STILL being given depot injections since they were also prescribed medications that had to be taken multiple times a day and as far as I know, they didn't struggle to manage those other medications. I'm just asking if, while a depot MAY be appropriate in certain situations, do people feel they needed the depot? Or Are people essentially being told that either they accepted the depot or could end up either sectioned or in breach of a community drug treatment order (CDTO).

Because this thread certainly doesn't read as people being happy with the outcomes.
Click to expand...
What is the tremendously long half life that you say it is?
People are not happy with the outcome, literally most of them are suicidal.
 
lukeflowz said:
I’m close to ending it all myself. This is unbearable. Every invasive thought I have is about wanting to die. It seems I’m not going to recover. I’m really close to ending it all.
Click to expand...
We are in this together, i too am only hopeful that i will recover. Otherwise, i am thinking of ending things myself.
 
Status
Not open for further replies.
Top