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Coming off Invega/Xeplion (paliperidone) injections v11

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twinpeaks123 said:
has anyone noticed their side effects worsened with each dose?
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I noticed this- - each injection made me feel worse each time, but it kind of plateaued after the fourth injection, and then it has maintained this intensity ever since. Even now- - three months off I feel the same. I've been suffering ever since. Apparently its normal for me to feel this way three months off, but even with this knowledge- - that I'm in early stages of recovery I don't think ill get better. It has been the worst time of my life and I don't know if this will end.
 
Am I correct in stating that paliperidone is an active metabolite of the older neuroleptic rispiridone BUT allows for a long-chain ester (palmitate) prodrug to provide a depot formulation?

If so, I am a little surprised as to my untutored eye, that's going to produce an extremely lipophilic prodrug. Haloperidol depot is the n-decanoate (10 carbon) ester whereas the palmitate (16 carbon) will be even more lipophilic.

All other things being equal, that's going to have a tremendously long half life. Now I don't know if other metabolic processes mean that the palmitate doesn't have the same half-life as haloperidol decanoate but I don't know of any such metabolism.

On a different topic, I have known some people who had been prescribed depot injections of various neuroleptics. In every single case, I asked why, after decades, they were STILL being given depot injections since they were also prescribed medications that had to be taken multiple times a day and as far as I know, they didn't struggle to manage those other medications. I'm just asking if, while a depot MAY be appropriate in certain situations, do people feel they needed the depot? Or Are people essentially being told that either they accepted the depot or could end up either sectioned or in breach of a community drug treatment order (CDTO).

Because this thread certainly doesn't read as people being happy with the outcomes.
 
RisperdalConsta50mg said:
Well only time can tell me if i will recover, i have 2 months ahead of me to reach 18 months and 8 months ahead of me to reach 24 months, most people say it took them 18 months to feel “ok” in a certain way and 24 months to feel normal ag
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So, while even a very simple virus can kill us, and while so-called medications like antibiotics, painkillers, and blood pressure drugs already have serious side effects, we now know that these fucking antipsychotics and antidepressants they give us are actually poisons that disrupt not only the brain’s chemistry but many different functions of the body. I don’t just think my brain chemistry was disrupted — I think most parts of my brain aren’t even working anymore.

And aside from that, D2 dopamine receptors aren’t only in the brain; they play roles in organs like the kidneys and pancreas. Anyone can look up what functions D2 receptors have and where in the body they’re found. And it’s not just the D2 receptor — they mess with many different receptors. What I’m trying to say is: yes, there is a blocking effect, and those sons of bitches who invented this poison have absolutely no idea what kind of chain reactions, chaos, and disaster they cause in the brain and the body.

After quitting the medications, I realized that this is not some long-lasting flu — the brain is an extremely delicate structure and should never be interfered with. Seeing people born with mental or physical disabilities made me think the body isn’t that perfect after all, and that the whole “plasticity” concept is just nonsense pushed by neuroscience. If the brain were so perfect, people wouldn’t fall into depression or psychosis in the first place, because when you first start taking antidepressants you go like “wow, is this really how people live?” — you get the effect, but at some point the brain can’t regulate it anymore, so either you increase the dose or you go into psychosis.

There are people who are predisposed to depression, and then there are the lucky ones. Both groups should never be exposed to these drugs. I’ve lost faith that I’ll recover in 6 months, and my condition is actually worse than most — not saying this to compare. I’m just saying we’re helpless creatures abandoned in a world God has fucked.


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4DQSAR said:
Am I correct in stating that paliperidone is an active metabolite of the older neuroleptic rispiridone BUT allows for a long-chain ester (palmitate) prodrug to provide a depot formulation?

If so, I am a little surprised as to my untutored eye, that's going to produce an extremely lipophilic prodrug. Haloperidol depot is the n-decanoate (10 carbon) ester whereas the palmitate (16 carbon) will be even more lipophilic.

All other things being equal, that's going to have a tremendously long half life. Now I don't know if other metabolic processes mean that the palmitate doesn't have the same half-life as haloperidol decanoate but I don't know of any such metabolism.

On a different topic, I have known some people who had been prescribed depot injections of various neuroleptics. In every single case, I asked why, after decades, they were STILL being given depot injections since they were also prescribed medications that had to be taken multiple times a day and as far as I know, they didn't struggle to manage those other medications. I'm just asking if, while a depot MAY be appropriate in certain situations, do people feel they needed the depot? Or Are people essentially being told that either they accepted the depot or could end up either sectioned or in breach of a community drug treatment order (CDTO).

Because this thread certainly doesn't read as people being happy with the outcomes.
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What is the tremendously long half life that you say it is?
People are not happy with the outcome, literally most of them are suicidal.
 
lukeflowz said:
I’m close to ending it all myself. This is unbearable. Every invasive thought I have is about wanting to die. It seems I’m not going to recover. I’m really close to ending it all.
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We are in this together, i too am only hopeful that i will recover. Otherwise, i am thinking of ending things myself.
 
anonymoususer777 said:
What is the tremendously long half life that you say it is?
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Well, it seems to vary hugely. While 24-49 days is cited in a few places, J&J state that discontinuation can take up to 126 days. But some NHS foundations suggest upto 18 months.


That's why I asked if people needed to be prescribed the depot formulation or could at least some of them simply take an IR formulation. Or if that's not available, would the parent drug rispiridone (which is quickly metabolized into paliperidone) be an alternative?
 
4DQSAR said:
Well, it seems to vary hugely. While 24-49 days is cited in a few places, J&J state that discontinuation can take up to 126 days. But some NHS foundations suggest upto 18 months.


That's why I asked if people needed to be prescribed the depot formulation or could at least some of them simply take an IR formulation. Or if that's not available, would the parent drug rispiridone (which is quickly metabolized into paliperidone) be an alternative?
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In my case they told me “if you want to go back to your home you have to get this injection” even if i never had non-compliance hystory, i was taking regularry my pills (paroxetine for panic attacks) and the diagnosis that lead to this depot was false, i never had psychosis.

They give me “cold blood” the max dose aviable with risperdal consta injection (50mg) without first a trial of 21 days with oral pills to see my response to that drug, then the first depot should be 25mg and not more than that dosage.

When I complained about ZERO benefits but instead effects and sympthoms i never had before in my life that were leading to me being in agony, asking for help while i was laying on the floor, instead of showing some humanity and mercy they give me second depot after 12 days by the first one instead of 14 days as the protocol says. Yes, it was again the max dose aviable: 50mg.

I’am 1.68m x 50kg and basically they intoxicated me with a seriously and deadly overdose, i’am not surprised i’am not recovered after 16 months honestly, i’am surprised i dint developed MNS or TD and i’am not dead by what they did to me. This is a miracle honestly.
 
@RisperdalConsta50mg - I was under the impression that Risperidal Consta doesn't work immediately so that sounds foundationally inappropriate for a psychiatric emergency. Or should I say that the intended action does not begin immediately?
 
4DQSAR said:
@RisperdalConsta50mg - I was under the impression that Risperidal Consta doesn't work immediately so that sounds foundationally inappropriate for a psychiatric emergency. Or should I say that the intended action does not begin immediately?
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Since i never had psychosis and i never had non-compliance about my oral pills, what was the pourpouse of these injections? What was the pourpouse to cold blood me with maximum dose without oral trial? What was the pourpouse of chosing max dose over a tiny underweight young guy? What was the pourpouse of keep injecting me while i was in agony? I don’t have a scientific neither medical answere to these questions.

My Logic lead me to answer that way: They wanted to hurt me, but why?
 
4DQSAR said:
Well, it seems to vary hugely. While 24-49 days is cited in a few places, J&J state that discontinuation can take up to 126 days. But some NHS foundations suggest upto 18 months.


That's why I asked if people needed to be prescribed the depot formulation or could at least some of them simply take an IR formulation. Or if that's not available, would the parent drug rispiridone (which is quickly metabolized into paliperidone) be an alternative?
Click to expand...
i am unable to determine the halflife of invega sustenna (monthly injection) based on what you are saying. Is it 24 to 49 days or is it longer? What do you mean by "discontinuation can take up to 126 days?
If you are someone who with influence, please i beg you to make people and drug companies aware that invega is the worst suffering you can put a human through. It is worst than torture. It is inhumane and cruel beyond your imagination. Most people here were forced to take it and most often misdiagnosed.
 
@anonymoususer777 - I am currently simply trying to understand what is happening.

Johnson & Johnson appear to be the sole manufacturer of paliperidone. So right now I am closely looking into their history. Their previous on-patent neuroleptic was rispiridone and it is no secret that they paid out many $ billions in lawsuits due to them mis-selling the medication.
 
Invegatorture said:
I told my dad I feel awful today and he replied "you look fine" 😩
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I think people who haven’t had injections see our suffering as something that can be fixed. Yesterday, I called my parents and told them of my issues and apparently all I need to do is exercise and start doing housework to feel better. I know for a fact that the only way I’ll feel better is if invega leaves my system and my faculties return. People from the outside don’t see that- -they think we can fix ourselves in the present moment.
 
4DQSAR said:
@anonymoususer777 - I am currently simply trying to understand what is happening.

Johnson & Johnson appear to be the sole manufacturer of paliperidone. So right now I am closely looking into their history. Their previous on-patent neuroleptic was rispiridone and it is no secret that they paid out many $ billions in lawsuits due to them mis-selling the medication.
Click to expand...
Go through the comments people here write, there is no hell worse than invega.
 
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