Well morphine is a substrate of CYP2D6, so is codeine, tramadol, hydrocodone, meperidine,fentanyl, etc. I can only assume (based on my little knowledge on the matter) that yeah heroin (and it's major metabolites) would be a substrate of CYP2D6.
Inhibitors include:
Clorpheniramine (can get dexclorpheniramine as polaramine brand antihistamine, i believe.)
Cimetidine
Ranitidine (zantac)
Quinidine, maybe quinine (tonic water anyone?)
Fluoxetine
Also I believe codeine is also an inhibitor of CYP2D6, so it could be worthwhile to take the smack 20mins prior to the codeine?
Be safe though, guys.
http://www.ildcare.eu/Downloads/artseninfo/CYP450_drug_interactions.pdf
Inhibitors include:
Clorpheniramine (can get dexclorpheniramine as polaramine brand antihistamine, i believe.)
Cimetidine
Ranitidine (zantac)
Quinidine, maybe quinine (tonic water anyone?)
Fluoxetine
Also I believe codeine is also an inhibitor of CYP2D6, so it could be worthwhile to take the smack 20mins prior to the codeine?
Be safe though, guys.
http://www.ildcare.eu/Downloads/artseninfo/CYP450_drug_interactions.pdf