Having taken almost every SSRI and Tricyclant Anti-depressant as well as 2 MAOIs and a hand full of other A-topical Anti-psychotics, I will say this the regiment i am on now is the best for anxiety. I have agoraphobia and social Anxiety disorder with panic attacks and i take 8 mgs of Clonazepam a day as well as 2 mgs of xanax on hold for panic attacks and 30mgs of temazapam for Sleep. yes you heard right, 3 benzodiazapines. IMO Anti-depressants don't do shit for anxiety except exacerbate the problem and cause horrible withdrawal symptoms. One of the worst of the bunch being Effexor, however, every one has a different body chemistry, thus while the 3 benzos work for me they may not work for others and they are quite dangerous to the average "recreational" drug user. the doses Im on in Co-administration for some one with no tolerance would likely kill them, with Alprazolam being the most abused Benzo in the States, temazepam being the most abused in Europe and the most seditive next to Rohypnol and clonazepam being the 2nd most abused in the states you will be hard pressed to find a doctor to prescribe such a regiment. Anyways, IMO benzos and other depressants like Ludes and Barbiturates are the best for treating the symptoms of Anxiety and panic attacks, however, Cognitive behavioral Therapy is the best way to ultimately treat anxiety issues.