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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Benzo Discussion

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hello everyone. can someone answer this question please!!--
why is the case made that you cannot insufflate a majority of benzos BUT you can efficiently absorb them through sublingual administration? the nasal cavity houses mucous membranes, it was my understanding that the oral cavity did as well. therefore both ROA would be equally as effective...? am i missing something here.
i know this topic has been covered time and time again but no where did i find any information about sublingual & nasal mucous membranes. thanks for any helpful input!
 
I'll admit I don't have a clue, but in doing so I'll bump this as it's a good question and there might be somebody who can answer it.

My guess is that solubility in water may play its part, but I can't tell you exactly how.
 
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I know that most benzos don't work nasally, because they're not water soluble. I don't know why they work (or even if they do) sublingually.
 
I'm pretty sure some of them do work sublingually, and not just the water-soluble ones. That doesn't make any sense to me immediately either.

Here we go.

Doesn't answer tread's question though, unfortunately.
 
maybe chewed benzos work sublingually by transdermal absorbtion.

I know from experience that sublingual midazolam & flurazepam (both water-soluble benzos) take effect in the same amount of time as sublingual alprazolam/diazepam/clonazepam/bromazepam etc. so its definately nothing to do with water solubility.
 
^ Yeah, I know that alprazolam and diaz do it. Had some lovely little melt-in-the-mouth tabs of both recently and I was going sublingual on the alpraz all the time.

Transdermal absorption? I don't know. Can somebody clear this up before I get so pissed off I need a benzo?
 
I would hazard a guess that the lack of sufficient (or maybe the "wrong type" of) moisture in your nose could be the problem with sniffing non-water soluble benzos. Water soluble ones work fine snorted - just the non-water soluble ones that don't. There's also lots of enzymes and stuff in saliva which may help absorption but dunno if they actually do. All benzos work fine sublingually but you can sniff diaz and the like all day and get zero effect. Well, they sort of work cos you end up swallowing the drip anyway so just get take it orally in a roundabout stylee if you snort them.
 
Enzymes in spit sounds like the most likely reason. They begin digesting food, so...
 
But how counter-intuitive is it that moisture (or lack thereof) would have an effect on water-insoluble benzos? :D

Maybe you're onto something with the saliva thing; there could feasibly be a reaction of some kind that facilitates sublingual absorption. Seems likely. Still, it'd be nice to know for sure.
 
I think it's the most likely answer. Believe me, I've been up for hours and the question still bent my mind somewhat. ;)
 
ya that sounds like it could have something to do with it shambles. both being Mucous membranes the moisture factor is the only variable between the two. that and maybe total surface area for more potential absorption..
I'm asking because when I began using benzos (alpraz. mostly) a couple years ago I hadn't researched the drug and, over time, started to insufflate. not aware of the debate. idk if its a mental thing or what but I swear it works just fine. I would go as far as saying better than oral admin IMO.
 
Tried xanax for the first time last night. (I've only ever taken Diazepam in the past)

I took 1mg and settled down to watch telly with a large red wine. After a while (30 mins), I started to feel slightly 'relaxed', felt a bit like diazepam, only even more subtle. So I thought screw it, I'll take another 1mg. Finished my glass of wine.

And I can't remember anything after that, other than feeling slightly sleepy. Next thing I remember is waking up on my couch an hour or so later. Then went straight to bed.

Sound about right?
 
Shambles said:
Sounds like Xanax. Unless I've built up a decent benzo tolerance even 1mg knocks me out, to be honest. 0.5mg or even 0.25mg is probably better with little tolerance unless you are using it purely to sleep.
Click to expand...

Was hoping to just use for a nice chilled out Saturday night in vibe, à la diazepam. But that didn't happen!

Normally 20mg of diaz with a small amount of alcohol gives a nice hazy, relaxed feeling, without knocking me out. I'd heard Xanax is more 'euphoric' (or at least more recreational) than diaz, so thought I'd give it a whirl. And I read 2mg equates to about 20mg diaz. Oh well, maybe I'll try 1mg and no wine next time.
 
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