Below is something of a Scotratic dialogue. For your convenience I will take the role of,well, Socrates. My good friend, goat-pauper and hedge-wrangler,
@fastandbulbous takes Secundus of Nitrobenzodiazepine,
@Skorpio to reprise his role as Empedocles of Agrigentum (why alter what works?),
@Smyth2 as Dick Dasterdly look-alike Aristobulus of Cassandreia and for one night only,
@Mushoku_Sensei will be channelling Wittgenstein (Die Grenzen meiner Sprache sind die Grenzen meiner Welt).
LIGHTS, CAMERA, INACTION
I'm gutted no post-grad applied for 'the study of isomers, bioisosteres and compounds related to glutethimide (Doriden). A downer that is also a potent (CYP2D6) inhibitor. Put simply, (2 x 200mg) Doriden (raecemic glutethimide) +120mg codeine ===> ≈120mg morphine.
Now I've read all I can find but at no point does anyone
resolve the two enantiomers. Has someone else checked this, I could be wrong?
Why does this matter?
We don't even know which of the two enantiomer are hypnotics nor if a hypnotic enantiomer is the enzyme inhibitor. We known one enantiomer undergoes pretty rapid metabolism' BUT later research showed it was a less toxic eantiomer (METABOLITE) that was responsible for hypnotic activity in MAN. Until the 1990s, we had ASSUMED it to be true!
Well, if the
CYP2D6 inhibition is solely caused by an enantiomer that ISN'T psychoactive if consumed alone, even
UK law crumbles.
Assuming the BEST outcome, two 100mg tablets of Laevoriden (laevodoriden) and 200mg codeine (or lesser quantities of dihydrocodeine, or hydrocodone, or oxycodone) and regardless of tolerance, you decide to lie down...) I only have two reports but one was a DOCTOR who had been in Rehab with Carrie Fisher! First comment was that it was not like codeine/morphine or any of the others I named or he named. It ONLY works for codeine homologues. You feel hungry and if you enjoy alcohol, get a couple of beers as you prep the sandwich.
You will sit, flick TV channel and as thirty seconds pass, it's eight hours later. He told me he ONLY ever used on 'the weekend' but maybe it was just him but weekends began 3.30PM Friday and ended when his driver used a wheelchair to get the guy to his desk 8.59AM Monday MORNING.
We couldn't understand how he was still alive but apparently yes he fell asleep a lot but was just tired. Appearing to be drinking a
b i t too much worked but he is 'the doctor' so if he didn't know, he probably just told himself a lie...
NB This is Ancient Greek Theatre so you are all past of the χορός. Don't forget, it's all pure invention so don't be angry if someone else snatches the last double-ended tibia. First magic, magic, then magic a triple-ended tibia and an extra mouth to blow with. Fashion tip - our fashion editor notes that as of now, the recently outdated double-ended tibia is now an internal wind instrument.
For decades we have been praying for Muhammad to visit the mountain* for manifold reasons. One being that founding THREE world faiths, it's easy to imagine the wrong surmon being read to the wrong mystic rune and 'we damned well WILL hold a vigil for another 1400 years. Meanwhile Greek doctors cash into the latest 'whole earth food diet' Earth, Air, water AND fire.
Or, 'in English', if a safe,legal and cheap pill that you can sell in 10,000 lots at 25p per.
*Essays of Francis Bacon (1625)
As everyone can see. This is hardly a practical exercise. It IS interesting, but gives some ideas of problems, risks, benefits, expansion BUT the moment it's found all enantiomers have at least some activity alone and suddenly is the UK. It's a perctectly valid and worthwhile project for PURE knowledge. But you have to accept that the odds are against you. Hence broken biscuits here.
Oh, While I remember, A later paper suggested that the -OCH3 we wish to be an -OH does so via the NH i.e. O-demethylation,N-methylation, transesterification. I strongly suspect that reduction of C=O may be involved but catalysis prevents isolation.
@Smyth2 I don't know if youpreviously red the refs. It seems every decade or so, someone does a bit more. I would just appreciate people believing because I READ, not because I say So! But just look at all of the major classes. Amide and/or Imine. I have been staring at them and it justs FEELS something is mussing.
