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I am dealing with immense criticism at dmt nexus, see thread here, this is what I told them:
A couple people even said what Xorkoth wrote was wrong, I told them I agree completely with everything Xorkoth wrote above. I have been reading the countless amazing post by Xorkoth for over 10 years.
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Doubledog said:
My friends had some ALD52 blotters few years ago and described it as slightly more visual, and not so stimulating, and as upgraded version of LSD, but with just small difference.
I always explained it in the way that this difference is similar to difference of morphine/acetylmorphine and it is based on different metabolism of molecule.
Btw.
Title of this thread is about acetyl-LSD, but content is mainly about acetaldehyde-LSD. It's confusing.
Take this 1-aceteldeyde LSD to the 300ug to 400ug level, it is like mescaline, which shines at the 300mg to 400mg level. Don't worry, there is none of the tenseness or anxiety of LSD, so it is easy to take it higher...but it has plenty of depth mentally. It is extremely visual at the 300ug level in a completely different way from LSD, more like mescaline or DMT in the visuals. This is for people who have plenty of acid to spare, if you do not have much acid to spare, then I recommend sticking with acid. This is just like cactus, it is more expensive to trip with, but well worth it imho, will not dream acid any other way from now on. This 1-acetaldehyde LSD imho would combine quite well with 300g to 400g of fresh cactus tea, making it feel more like 600g fresh cactus (no core).
With 300ug conversion: For anyone that does dream this, you may be shocked at how stimulating it is the whole trip, as ALD-52 or 1-acetaldehyde LSD created via this thread has "twice the anti-serotonin power of LSD", and the more anti-serotonin or serotonin blocking (see color receptorome chart on post #1) the more powerful the stimulation, was up till 4:30am in the morning, and had dreamed it at 4pm in afternoon. The girl I was with had to tell me to "stop talking" at one point, as I kept pointing out "how beautiful the scenery was", the stimulation is high, but still mentally relaxing none the less, although a great psychedelic head space, it will take you deep mentally without the anxiety or tenseness of LSD just as Shulgin writes in TIHKAL under ALD-52 section.
It is way more colorful than acid and if you wave your hand in front of you, instead of just seeing multiples of your hand like you would with acid, you will see not only multiple tracers, but inbetween the tracers will be fractals and swirls of color, super fine colored rainbow reflections surrounded almost everything I watched, immensely beautiful. Patterns and textures do indeed shift like crazy with open eyes. It is vastly different from LSD. With closed eyes I saw the most beautiful geometrics, before falling to sleep, saw architecture and gardens like those in Versailles, France with a fast moving groundskeeper zipping about tending to the plants, unbelievable.
Why so different from LSD? I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead (see color chart on page 1 of this thread) which is the high binding dominance or habitat of mescaline & dmt, and psilocin to a lower extent.
benzyme said:
I just don't see it...
as with LAH, that acetyl group looks like it would be cleaved with moderate [H+], the carbonyl is obviously nucleophilic. nevermind enzymatic deacetylation; it likely wouldn't even make it to the liver.
This is Happening in the Liver via an enzymatic reaction, there is no cleavage, there is transformation taking place in the liver similar to what is happening in Note (1).
The proof is in the pudding, when someone else dreams this, and reports back.
The Mayans and Aztecs added the extract from morning glory seed to beer/wine, they did not do this with any other entheogen. Sherry wine contains 10mg acetaldehyde per shot glass. The priest at Eleusis added fresh mint to their secret entheogenic brew for over 2,000 years straight, mint contains 2mg water soluble acetaldehyde per 5 drops concentrated extract.
All these ancient people were not stupid, they were quite clever, there was a reason they did what they did. Fresh morning glory contains LSH and penniclavine in sky high amounts, as does the claviceps paspali which infects the paspalum distichum grass which grows next to Eleusis in the famous Rharian plain, Both contain the exact same alkaloids. If you do this same experiment I did with LSH, it also transforms the molecule.
Note (1) Here's an example: If you soak coca leaf tea bags in wine, and the wine drunk, the cocaine is converted into coca-ethylene in the liver...cocaethyelene is orally potent, it has a "higher like" rating than even cocaine when human tests were done in 1994. This was the basis behind the famous commerical "Vin Mariani wine" back in the 1860's popular with both Popes, Thomas Edison, and scores of other famous people. I don't see any cleavage taking place with this molecule but rather addition/transformation. This "in-vivo" liver transformation of the molecule was not even discovered till 1994.
How can you all call me wrong, when none of you have even tried this? I will report back in 2 weeks with a 400ug experience. This is not a rat taking LSD mixed with a shot of sherry and 5 drops peppermint in the lab, this is a human experiment, let your liver do the work, you will see the light.
Still do this the way the study outlined, by letting all sit in fridge for 3 hours with swirling once per hour like I did. The Sherry is already at ph=4 so no acidic solution necessary.
The study hints at the possibility of in-vivo adduction of acetaldehyde to indole at the NH group nitrogen as well. I performed the study externally, just as the researchers did. The same study I discovered over 22 years ago, it is from 1992.
