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Allergic To All Painkillers !!!

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No wonder her boyfriend doesn't want to get too close.
 
^^^ Hehe, made me laugh on the fact that it was quite unexpected and the funny comment, cheers Ham-milton :)
 
nabollocks, Ive never tried steroids and havent had any blood tests recently as my speicalist did overkill on the blood tests int he past few years but nothing recent.
 
Not even corticosteroids?

These are normally given for people experiencing allergic rhinitis. Or any allergy that impacts on your airways.

Do you experience asthma? If yes, what meds are you taking?

And...

I want to know what type of antihistamines you tried? How long did you take them? How did they make you feel? Were you allergic to the antihistamines?

Have you tried COX-2 Inhibitors? Meloxicam for example?

Can you refresh my memory on where you are in pain? And why? What hurts? How often? Does it get better and worse? Or is it just bad all the time?
 
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No I havent tried Corticosteroids, when Ive had an allergic reaction the only thing Ive done is taken antihistamines and gone to the emergency room and ride it out there or at home.

When Ive been offered treatment at the hospital for adrenaline shots or naloxone Ive refused it on the account that my body is so sensitive an unpredictable. Ive been apprehensive to try counteractive methods. The only thing Ive accepted is ant-acid for the rise of stomach acid experinced during my allergic reactions.

When I have allergic reaction I experince wheazing similar to asthma otherwise I dont have issues with asthma.

Ive only tried 2 antihistamines, first one was periactin after Grue on page 1 of this thread suggested it to me, but it knocked me out and made me feel more drowsy and fatigued than anything else Ive taken in my lifetime. It was full on!

So now im taking a non drowsy antihistamine called "Telfast" and Ive had no side-effects from it whatsoever altho i havent noticed it help with the fentanyl adverse symptoms.

My pain is in my ankles, knees, hips, shoulders and neck. My muscles get rigid and stiff and lock up and cause me to wake up in pain during the night finding myself in all sorts of contorted positions and I can only get back to sleep after cracking those locked up areas , also have problems with superficial nerves that cause numbing, tingling and pain in my ankles, The pain is the worst ion my knes making me feel like im walking on an open flesh wound and ocassionaly an electrical jolt sensation on every step, the pain varies depending on the location but I walk around limping like an old man at the age of 30. The pain is everyday and pretty constant but mainly worse with movement making it difficult for me to walk or stand up for too long, I sure miss going to raves and dancing my ass off for 8 hours like I used to , lol.
 
my mom is allergic to all codien based narcotics and any other opiate she as fibromyalgia and osteo arthritis.

that sucks dude. well i gues ull never go through w/d which i am at them moment "NOT FUN AT ALL"
 
What is your daily dose of Telfast?

To get any real relief you need to take at least 90mg twice a day.
For serious allergies you may need 180mg twice a day, but this is definately not a long term solution.

Do you urinate more than an average person your age?

For example: do you pee more than 2-3 times a day?

And have you tried COX-2 Inhibitors? Meloxicam for example?
 
^^^ Do you think antihistamines could be useful even with a substance like fentanyl which supposedly does not cause histamine release?

I still take 120mg of telfast daily just incase it does help. I normally urinate about 2 - 3 times a day but when im having a severe adverse reaction then something odd happens and I find myself going up to every 15 minutes until my symptoms settle. Even if im passing just clear water, it feels like my body is trying to get rid of the substance in my system thats causing me adverse reaction.

So whats the verdict? Did any of my answers mean anything to you or give you an indication as to whats gone wrong with me?

No I have not tried Cox-2 inhibitors like I said up until now I have been reluctant to try any new medicatios and only used the most essentials.
 
Well, it is a bit early to tell, but my initial thoughts would be that you should go and get some allergy tests done.

There are only a couple of doctors in Australia that are actually specialists in this field.

I would get some X-rays, and CT's done on your joints and check for any loose particles, and check for arthritis.

I would avoid opiate pain medications as I have not seen anything that you have described that can actually be helped by opiates. (Opiates just change the way you percieve pain)

I think you really need to get your allergies sorted out first, and I think a lot of things will follow. This may involve some corticoseteroids. (I cannot believe that this has not been tried by your MD)

As a side note, Cox-2 inibitors are anti-inflamatory drugs that do not give you the side effects of traditional anti-inflams. They are actually very helpful at helping to reduce pain at the site. (Joints in your case)

I would try and do some swimming or cycling to get your body working for itself.

Do you sleep well? How many hours a night?
 
just be aware that the COX-2 inhibitors have been implicated in heart damage, thrombosis and the like. but i'd say that in your case, if it helps it is definitely worth the risk.
 
Nabollocks, Ive hada lot of specialist visits and have ended up here looking for help after none of those so called Dr's were able to help me.

The Immunologist at the Allergy Centre at the Alfred Hospital was one of the few specialists who particularly study drug allergies as opposed to all the other allergists who study environmental and asthma type allergies. Even he said he didnt think he could help my particular situation.

Ive had so many x-rays and MRI's which only found torn ligaments in both ankles and torn cartlige in both knees. I had knee surgery last year and require further surgery on my other knee and both ankles but refuse to have it done on the basis that I had a severe adverse reaction in hospital from post surgery pain medication following the surgery and on top of that ive now developed adverse reactions to fentanyl which was one of the analgesics they used in my surgery. Things are so complicated with me as I was able to use some of the medications at least once or a few times before my body began to reject it and unfortunatly the fentanyl used in my surgery was one of them.

I have seen rheumatologist and my neurologists who tested me for arthritist but found none. It is believed that the detereoration in my joints are of a neurological basis. At one point I was seenga physiotherapist regularly and excercising but the excercise only made me worse and now im at a point I cant leave the house to walk due to the pain. Although you dont think the opiates are necessary they gave me my life back as i found myself able to get out and walk without noticing the pain too much but this was short lived after i developed adverse reactions to them.

Ive avoided NSAIDS until now due to the fact that one of my major dysautonomia symptoms is gastrointestinal issues and blood presure and anti-inflammatory medication like COX-2 inhibitors are likely to aggrivate this....

http://www.bmj.com/cgi/content/full/331/7528/0-b

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1117248

Thank you for everything youve done for me though, you have been amazing with your willingness to help me but like I said earlier everything seems to be catch-22 with me cause my life seems to be one big cruel joke.
 
Is there not a single surgeon on ADD? I would have thought by now that someone would have suggested that Unlucky see if he can get his hands on Dantrolene. It's the only thing on an Malignant Hyperthermia cart in an OR (other that crap to combat acidosis). I'm not sure if anyone uses it outside of surgical complication, but it sounds like when you have an attack, it's the only thing that could prevent muscle breakdown resulting in the released myoglobin destroying your kidneys like in untreated MH attacks.
 
Ive tried Tramadol, Morphene, Digesic, Codene, Oxycodene, Hydrocodene and Fentanyl patches, every one of these ended up with me at the emergency room with difficulty breathing and swallowing, muscle spasms, irregular heart beats, overheating and rashes
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you sure you arent just taking too much? those are all symptoms of OD.

maybe you are hypersensitive and need to try tiny doses?

forgive if this was already discussed, i didnt read the read, its pretty long
 
qwe said:
you sure you arent just taking too much? those are all symptoms of OD.

maybe you are hypersensitive and need to try tiny doses?

forgive if this was already discussed, i didnt read the read, its pretty long
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you know what qwe...your so right, I often think it feels like an overdose to me as well but the odd thing is I take tiny doses. All my adverse reactions have been of minuscule doses like half a 50 mg tramadol or one 30 mg codene or one low dose oxycodone or just keeping on a 12mcg patch of fentanyl for only 4 hours a day when the recomended length is 3 days.

Its freakin ridicilious that I experince such severe effects from such small doses. Ive obviously become hyper-hyper-hyper sensitive but why? I feel like i have the body tolerance of a new born infant , lol
 
leungkachong said:
I would have thought by now that someone would have suggested that Unlucky see if he can get his hands on Dantrolene.
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Ive just looked up Dantrolene and I think you may be onto something worth trying out. thanks il suggest that to my Dr's.
 
Yah, usually if someone has significant acidosis, high CO2, the respirator needs to be turned up really high... Surgeon might check temp for an MH reaction to the anaesthetic. The MH cart (specifically dantrolene) is basically a quick-fix life saver. It's used in neuroleptic malignant syndrome, serotonin syndrome, etc also. Sounds like it's your bag of beans, at least in reversing severe attacks and preventing resultant toxicity. I'm extremely suprised they never mentioned this when you've gone for surgery or that opiate testing session you had!
 
Hey mate, I am not bagging you for using pain medication. I am with you on them being a life saver... I was merely referring to your symptoms when I said that you did not need them. As in: They will not fix the problem, they will mask it.

Have a read up on eicasonoids (prostaglandins, thromboxanes, leukotrienes) and platelet activating factor (PAF), as these all play a role in allergic reactions and may in some cases surpass the role of histamine.

How is your Telfast going?

What type of house do you live in? Damp? Dusty?

Have you had a scratch test?

If you want me to quit... I will, but you remind me of someone special :)

You just got to keep at it mate, don't give up and just admit defeat. Get out there and get some more tests run. Don't do anything you don't want to, but I can guarantee the day that you find the solution, you will be over the moon.

Keep researching, keep experimenting, and most of all keep active! Even if it hurts!

Hey, I just had an interesting thought... Have you ever injected pain killers? Or have you ever placed one up you know where?

ROA can have a dramatic impact on allergic reaction.
 
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By the way, I do not think your primary problem is a drug allergy, I believe it is something that we have missed.
 
Jamshyd said:
- I am pretty sure there are opiates that do not cause histamine release. I believe meperidine is one of them. Have you considered this? Yes, it is a bit toxic but it is still better than pain, IMO.
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All opiates are 'toxic'.
 
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