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Allergic To All Painkillers !!!

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I have not heard of eicasonoids but I will be sure to read up on it, how did you find out about all theses lol, you seem pretty knowledgeble. Again I thank you so much for taking an interest in my condition, I really owe you and im very grateful for all your help.

Im not sure if the Telfast is doing anything because as I mentioned earlier the fentanyl dosent release histamines so it seems kinda useless.
Ive also stopped with the Tramadol last week after having a severe episode, I overheated so severely I ended up runing outside shirtless 1 am in the morning, it was a freezing cold night about 2c degrees out there but I could not feel it. I was pouring water all over myself with a bottle and was soaked , had steam rising off me but still felt overheated and realy sick. I spent about 20mins out in the cold, I didnt feel right, my mouth and face kept going numb and I had thise sense like i was slipping away and dint know if i would make it through.

My house is neither damp or dusty, but if your suggesting my environment may have contributed to my condition im certain its not the case, I live with my folks who take care of me and their very healthy. But like I explained in my first thread on these forums it all started after that unforgiving night 8 years ago where I overdosed on coctail of party drugs and its been downhill ever since. The fisrt thing I noticed following the overdose was that my body had developed an allergic reaction to recreational drugs even though I had previously taken them once a week for many years at raves without any prior issues.

Ive only had intrevenious opioids in hospital of morphene and tramadol and each time the outcome was terrible with me having adverse reactions to them in hospital. I will try keeping positive, thank you for your advice, im continuing to try and desinsitise myself to fentanyl by wearing a patch everyday but I somehow cant get past the 4 hr mark cause thats when the symptoms get worse, I feel like pushing it thou cause deepdown ive basicaly had enough of this crap and I feel like if I happen to die it will be my ticket out from this mess Im in.
 
Kind of a personal question, so feel free not to answer.

Do you suffer from hypogonadism?

Have you ever had your testosterone levels checked?
 
No I dont have hypogonadism and feel free to ask me anything you like, after all you are helping me out.

I dont recall a testostorone test but I did have a 24 hour catecholamine test which if I rember correctly looks at hormone levels, but the results came back normal on that. I was trying to work out the reason for your question, is it because people with hypogonadism suffer from hotflashes and you tought perhaps my overheating was due to that?
 
Hypogonadism is just a pointer... but easily overlooked, especially when you have other more prominent symptoms.

I believe that your catecholamine test would have only been to monitor your thyroid for production of epinephrine (adrenaline) and norepinephrine . They quite possibly did not look at testosterone.

This may be something to think about? You said your were around 30 didn't you?

I am only suggesting these things, because you know what is worse than what you have now? Answer: Having an opiate dependance + your original problem.

So, you did not answer my question about the scratch test. Have you recently had a scratch test done for known allergens?
 
Yea you make a good point, I could be worse off if I developed and opiate dependancy along with the existing health problems.

I havent had a scratch test but when I arranged to see an immunologist (allergy specialist) he said he wasnt able to help my condition.

I will request my neurologist to give me a testostorone test. I understand your trying to understand or work out my condition by eliminating possibilities and asking questions to see if I have anything else contributing to my condition but personally I dont have a doubt everything im experiencing is related to that god dam overdose I had that day 8 years ago. Because I developed a neurological problem right away the next day after I'd taken drugs at a rave after my initial overdose.

Everything up until that point in my life was great, I had no health problems, I used to indulge in all sorts of drugs every weekend, id be suprised if there was a recreational party drug out there that I havent done. I could go out and take what ever I wanted without any side effects or issues, but soon as I had that overdose EVERYTHING changed, I immedeatly developed an allergic type reaction to recreational drugs. Weeks later I refused to accept my fate and once again I tried a tiny amount of drugs with the same adverse outcome and THAT night I developed chest pains and overheating and other symptoms which hasnt gone away for the past 8 years. Later when I became diagnosed I found out I'd developed Autonomic Dysfunction and everything ive been experincing since that night are mainly symptoms of Dysautonomia. It pretty much happened overnight, I broke something in my brain, and I bet its something so small like a neuron , axon , or something in the hypothalamus or preoptic area that ive damaged that has evolved effecting my whole body in the form of hypersensativity and all the other symptoms.
 
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I believe all that you have said, but if I were you I would:

1. Rule out known allergens by a prick test. (I can give you the best reference in Aus if you like)

2. Get your Test levels checked. (If this is not in check, it can play havoc with your immune system)

It is possible you have done some brain damage, but I highly doubt it.
 
^ possible for brain damage?

i may be wrong, i only did a quick google search of autonomic dysfunction, but it basically said that it's a permanent, incurable condition. and that the only treatments are palliative.
 
Sturnam said:
^ possible for brain damage?

i may be wrong, i only did a quick google search of autonomic dysfunction, but it basically said that it's a permanent, incurable condition. and that the only treatments are palliative.
Click to expand...

That is assuming the diagnosis is correct. ;)

Giving a diagnosis of autonomic dysfunction is sort of like the doctor saying "You have cancer".

The next question you ask the doctor is: "Cancer of the what?"

It is a nice way to group a host of symptoms under one name. If you can individually target each of the offending parties, you can at least have a shot at fixing the problem. The real reason we give names to these conditions is because we do not understand them fully.

For example: Do you remember consumption?

One day we will understand everything about the human body, but until that time, it is trial and error.
 
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Unlucky: If you get the chance to get these tests done, can you give us an update?

I also have a suggestion for a drug that might be of use to you, but am not a doctor so will not suggest it online. However, feel free to PM me if you want to know my thoughts.
 
nabollocks said:
That is assuming the diagnosis is correct. ;).
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The diagnosis is correct beacuse I had extensive tests by both a neurologist and a world renowned professor known for his findings in autonomic dysfunction whom I see at the Baker research clinic. Both specialists came to the same conclusion. But the first person who initially discovered my condition was ME after I typed my symptoms over the web using good old google search.

The specialists did many state of the art Autonomic testing in autonomic lab which took several hours over several days where they measure the bodies automatic functions through various methods including a table tilt test where your heart rate and blood pressure are monitored as a table that your strapped onto tilts from lying to standing position.

I also had a gut mobility test that tracked radioctive food after ingesting and seeng how its processed that proved my digestion was abnormaly slow due to autonomic issues.

I had a sweat test which showed abnormality and that I had lost the ability to sweat.

I had a deep breathing test and something called Valsalva maneuver.

I had long wires pushed in to the veins in my calfs and arms to measure the electrical impulse produced in muscles and veins when a person stands up as the body attempts to contract the veins in the legs to combat gravity so the person has enough blood left in the upper half of the body for the brain and heart to use. In a person with autonomic problems this contraction does not happen as it was found with me. This intrusive test left me with alot of brusing lol.

I had a blood test after they discovered that only people with Dysautonomia have a change in their NET gene. A protein binds to the end of that gene causing hypermethylation of the norepinephrine transporter (NET). as it was found to be the case with me as well.

I also volunteered at the hospital for other autonomic tests in order for them to discover cures and each tests also confirmed I had developed this condition.

It happened pretty much overnight and before the night of the overdose I was at %100 health and I dint have any problems and because my condition developed from recreational drugs there are elements and symptoms in my condition that are even more uncommon that no one seems to be able to understand like the constant overheating and the adverse reactions to all painkillers and recreatioonal drugs. Even with Dysautonomia patients overheat ocassionally and experience chemical sensitivities but its no where near to the extent of what I have and thats where I belive the key is the overdose that I had which did something unusual to my brain along with the fact that it happened during sexual activity so it messed up certain intricate areas.

but Nabollocks I am still going to have an allergen test and get my Test levels checked because I dont want to leave any stone unturned I will report back and check your inbox. Thanks
 
I have do doubt that what you say is true Unlucky. But until that day that the doctor can tell you why you have your condition, it is up to you to fix it.

All the best buddy. Looking forward to hearing from you again.
 
I still think memantine is an interesting avenue to examine, in that hyperactivation of NMDA seems to be an important component of overheating, allergic, and inflammatory sequelae.

The drug is a bit dirty in its binding affinities, though. Any strategy, if introduced, needs to be very carefully introduced with you.

Do you supplement anything, lucky? I wonder how you would react to supplementation of an absorbable magnesium chelate.
 
As someone mentioned earlier, have you considered deep brain stimulation or any other experimental techniques like this?

It sounds like you have most certainly damaged part of your brain from the OD so things like this might be the next step.

All the best, I hope you finally manage to fix yourself up :)
 
I wonder if there's anything like a high-affinity partial agonist/antagonist at adrenergic receptors that could buffer high levels of norepinephrine/epinephrine release that probably occur as he overheats.
 
Rolls...I havent considered deep brain stimulation but from what I read its an invasive surgery which is a problem because surgery means anesthesia and anelgesics which which is the very probem Im confronted with right now.
Thanks for your well wishes though.

Grue...On my next appointment with my neurologist I will definetly make the suggestion to try memantine along with what nabollocks has suggested to me.

The last comment you made above triggered something in me, it made me think that when I do overheat there must be some obvious changes in my body during the more severe episodes and there has to be a way to measure this maybe in my blood and im just upset no ones done this yet? What sort of a test do you suggest for them to do to detect this?

Im even willing to volunteer as a lab rat, a definite trigger for overheating in me is either sexual activity, getting upset or overexcited, being in a warm room, and worst of all taking painkillers that cause me adverse reactions. So if my neurologist allows me I want to have an adverse reaction in a controlled setting by taking painkillers just so they can work out why I overheat so badly. So did you say you think it may have something to do with norepinephrine/epinephrine, is this what they should be measuring?
 
They have already tested for norepinephrine/epinephrine. I'd say you are probably in the clear there.
 
They have already tested for norepinephrine/epinephrine. I'd say you are probably in the clear there.
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Well, the catecholamine test came back normal for his day, but I'd be quite surprised if norepinephrine/epinephrine weren't elevated when he actually overheats ... I mean they are pretty incident to the process in normal temperature increases or hyperthermia, right?

The idea I had, which might be stupid, was that if there's a partial adrenoreceptor antagonist/agonist with high affinity, then at the right dose it might work something like memantine does with NMDA? -- buffering (by occluding the receptors with its higher affinity) excessive levels of NE/E when they manifest (as in the overheating response, I think) but leaving regular catecholamine transmission intact.

The last comment you made above triggered something in me, it made me think that when I do overheat there must be some obvious changes in my body during the more severe episodes and there has to be a way to measure this maybe in my blood and im just upset no ones done this yet? What sort of a test do you suggest for them to do to detect this?
Click to expand...

You're quite right I think ... for instance it would be interesting if tests, actually during your hyperthermia, would turn up something that differs from typical hyperthermia?

Temperature regulation is complex ... I would like to see an expert on it pipe up.
 
I am actually allergic to every pain killer that I have tried too. I was just diagnosed with "chronic headaches" not too extensive as ’ condition... at all but it still hurts like hell. So far I have had Vicodin, Hydrocodone, and now Tramadol. They all make me itchy like no other. I know you haven't posted in a long while but I was wondering how you're still handling it now of days? I am afraid that my allergic reactions might get worse so I thought maybe you had some advice or ideas?
 
Hello i was reading your post and i wanted to send a reply so i had to register i was aslo wondering what the fuck i can take for pain as i also had an over dose bout 12 years ago now but i survied they pumed my stomach i am allergic to EVERYTHING not only pain killers (every pain killer on the market and then some ) certain creams hay fever meds cold and flu meds absoulutly everything i recently had a heart attack they tried to give me synthetic morphen and im still allergic to that i have broken my back ..been in car accidents and cant have nothing for any pain and people want to know why im not a very smily happy person.. i have asked doctors specialist they dont know shit they think im kinda a freak of nature with all the health issues i have i thought i was the only one with these issues it drives me fucking mad does my fucking head in and the world is so judgemental thinks it knows everthinh bout you and can judge you
 
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