• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Allergic To All Painkillers !!!

Status
Not open for further replies.
U

Unlucky

Bluelighter
Joined
Apr 26, 2007
Messages
594
Im in such desperate, hopeless and helpless predicament I dont know what to do. I know you guys arent Doctors but I got no one to turn to, it seems the medical world isnt ready for me yet. Every specialist Ive seen has told me they are unable to help me so Im here posting in the hope you smart people can suggest some other ideas to me cause im all fresh out.

Some of you may know my history about me developing a neurological condition known as "Autonomic Dysfunction" after overdosing on recreational drugs 8 years ago which left me disabled and fuked up to say the least.

On top of that I developeded some sort of a muscle muscle and joint pain and soon discovered that I had severe adverse reactions to any painkiller that was given to me. Ive tried Tramadol, Morphene, Digesic, Codene, Oxycodene, Hydrocodene and Fentanyl patches, every one of these ended up with me at the emergency room with difficulty breathing and swallowing, muscle spasms, irregular heart beats, overheating and rashes. Some of them I was able to take a few times before I developed an allergy but once the allergy started the outcome was the same each time.

Most people who cant tolerate one painkiller can take another alternative but what the fuck is wrong with me, why am I so messed up that I cant take any narcotics whatsoever. My neurologists dont understand why , the allergy specialist (immunoligist) didnt even want to se me after he heard my case because he dint think he could help me in any way.

It all started after the fucking overdose I had upon which I found myself with a drug allergy and a neurological condition, I was fine before all that crap happened to me, i could take any substance without any issues.

Somehow its all related but no one can figure out how or why!! fuck Science and fuck Doctors and fuck the medical world, why cant they work me out???:X

How am I one of the few people in the world if not Only who developed "Dysautonomia" after a drug overdose, why the fuck am I stuck with such a rare condition, couldnt I have just fucking died instead! And why the fuck did I have to develop a chemical sensitivity following the overdose and why the fuck is it making it impossible for me to take painkillers 8 years later?? And why the fuck am i one of the few people in the world who have such a broad spectrum allergy to all painkillers? Why does everything have to be so fucking complicated? And why the fuck am I the only person in the whole fucking world who is constantly feverish and overheating everyday for the past 8 years? what the fuck is wrong with my brain? which part did fry during the overdose that has me so messed up?!! And why the fuck is science so fucking behind that no one can help me? What the hell am i supposed to do for the severe pain im in everyday and what the fuck am i supposed to take in the case of an emergency or accident or surgery? I feel like im walking a tight rope without a fucking net and I cant even find one Dr or specialist out there to help me! :(
 
I am very sorry to hear about your condition :(

While I cannot tell what went wrong with you, here are a few thoughts off the top of my head that may help:

- Have you tried taking a strong antihistamine before, during, and after you take the opiate?

- I am pretty sure there are opiates that do not cause histamine release. I believe meperidine is one of them. Have you considered this? Yes, it is a bit toxic but it is still better than pain, IMO.

- Have your doctors tried treating your pain with Gabapentin or Pregabalin? These are not classic painkillers, but they seem to cure a lot of people's neuropathic pain.

- I know this is almost pointless to suggest since, to your doctors, you have a "substance abuse problem", but you may want to suggest to them Ketamine as an alternative since your case is so severe. After all, if they're willing to prescribe you fentanyl, I am sure Ketamine would be less of a hassle.
 
I think the Fentanyl was the last straw for the Doctors at the pain managment clinic. They were very patient with me and trialled all the other painkillers but finally after the fentanyl allergy they came to the conclusion I had some weird drug allergy that was causing my body to reject it all and they no longer wanted to risk my wellbeing with further trials.

Somehow I feel like if I go back with a new list of suggestions they will not be willing to re-trial as they have alreday stated they will no longer do so, but I will try.

Somehow I feel that Ketamine will also be too hard on my body cause my autonomic nervous system is so sensitive and out of whack it feels like its not letting me take anything that has the potential to stimulate my nervous system.

I cant even imagine getting high anymore, even with basic stimulants like alcohol or cofee my body flips out before I even get the chance to experince a buzz. So I cant even use anything for medicinal purposes.

I can describe my life in one word "Catch 22". Its like i cant take this cause of that and i cant fix that cause of this and etc etc. if you know what i mean?

Its like a cruel joke, I have been denied the right to ever take any substance to a level where it stimulates my body even if it is for the purpose of releiveing pain. I can only remain sober and put up and suffer with all the pain in my life. Someone up their must really hate me.
 
What really upsets me is the whole "CATCH22" deal !.......

-Dr- "If your in pain try painkillers."

-Me- "I tried them and I had allergic reactions to them"

-Dr- "Then try anti-inflammation drugs for pain"

-Me- " My Autonomic Dysfunction causes severe Digestion problems and anti-inflammation drugs aggrivate the stomach.

-Dr- "Here try some anti-depressants, amitrypline helps with pain also"

-Me- "I can't take antidepressants cause their influence on my brain chemistry aggrivates my autonomic symptoms even more causing my overheating to get worse"

-Dr- "Have u tried getting a job to get ure mind of ure health problems"

-Me- "I cant work cause im so debilitated by my Neurological Condition"

-Dr- "Have u tried exercising?"

-Me- "I can't excercise cause of the torn ligaments in all my muscles and joints and the pain"

-Dr- Try some hydrotherapy in a heated pool"

-Me- "I cant cause I overheat already and hot water makes me feel even worse"

-Dr- "Get surgery to repair your joints"

-Me- "I cant have surgery because I have allergic reactions to painkillers and known issues with anesthesia."

-Dr- "I'll refer you onto some specialists"

-Me- "Ive already tried all the ones youve mentioned and they couldnt help"

-Dr- "Im afraid I cant help you either, Ive tried everything and your a difficult case"

-Me- *thinking* (ye thatd be right)

there you go folks that catch22 at its best, I have so much more where that came from but i wont bore you with it but sometimes it gets bad enoff that I wanna just jump off a cliff or something. I am honestly as unlucky as they get! and that bad luck flows through every aspect of my life.
 
Last edited:
Are you sure you don't have an immunicological disorder? You should be able to reduce the reaction to mu-opioid analgesia with promethazine.
 
-Dr- "Get surgery to repair your joints"

-Me- I cant have surgery because I have allergic reactions to painkillers and known issues with anesthesia.
Click to expand...

They operate on folk who are hypnotized or have had acupuncture in stead of regular anesthetics . . .
 
Nuke im pretty sure I dont have a immunicological disorder as there are no symptoms where I experince allergic type issues to my bodies own chemistry, its purely towards other chemicals and drugs.
 
Jude i have heard about surgery being done under hypnosis before but when i mentioned it to the orthopedic surgeon he said he would not be willing to repair torn cartligaes with such procedures and dint believe anyone could put up with such pain.

Personally though this is where catch 22 comes into play again...I would not go through a surgery with hypnosis because my neurological condition causes me the inability to deal with stressful situations as healthy people do, because when i get stressed out i overheat even more and then overheating causes me to have rapid heartrates just as people do with heat stroke an dthen it turns into a vicious cycle and my symptoms flare up.

So basically the stress of having surgery whilst fully concious would without doubt cause me to overheat to that level where i get pretty sick. Heck I get sick from overheating just trying to beat the high level boss on a computer game and end up turning it off because my body cant handle it, so that should give u a rough idea about how messed up I am.
 
IMPORTANT!! as this may be the key!........

Ive only mentioned being allergic to painkillers here because thats what I NEED to be able to take for my pain but if it hleps anyone work out whats wrong with me then I should mention Im also allergic to recreational drugs.

Thats what it all started with, following my overdose I found that I could no longer take meth/speed, pills, mdma, mda, smoke marijuana without having severe reactions. Even the smallest dose would cause me to feel sick and experience severe hyperthermia, so could the allergic reactions to painkillers be related to the allergic reaction I developed towards recreational drugs somehow. Is it all an extensions of that?

If so then what sort of change in a humans body could suddenly trigger a person to become intolerant to ALL recreational type drugs and all painkillers?
 
I wonder if memantine might be useful for your really shitty accident.

Some of hyperthermia etiology seems to involve excessive NMDA activity ... memantine could in theory put an upper ceiling on this, even without compromising "normal" functioning (so you don't get a ketamine-like effect). Like I read someone in another thread, NMDA antagonists typically lower body temperature, dose-dependent of course.

It's a somewhat dirty drug though ... just on intuition, the muscarinic activity might be problematic for you. You would want to titrate upwards very very slowly ...

You're strong, man.

http://www.sciencedirect.com/scienc...serid=10&md5=8fb2331784499f00900cbb41d791ac86

Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model of serotonin syndrome:
http://www.ionchannels.org/showabstract.php?pmid=15048612
 
Last edited:
Side note: I think this is all VERY interesting in the context of the interactions between memantine and opioids, wherein memantine blocks opioid tolerance, perhaps, for one, by preventing excessive glutamate firing in the VTA which desensitizes dopamine neurons ...

I recall someone who was using the memantine/psychostimulant combination successfully without any tolerance whatsoever to mood/motivational benefits for over 2 years saying that the amphetamine still would stop working at times, following intense exercise, and he believed for some reason that this was related to overheating. Whenever this happened, the amphetamine lost effectiveness, and he needed to drop it for three days before starting again.

We want to look at the relationship between NMDA and hyperthermia.
 
Another thing -- your overheating occurs in response to stress, a condition which seems to also have excessive, neurotoxic NMDA firing as a major feature underlying some of the sequelae ...
 
grue said:
Another thing -- your overheating occurs in response to stress, a condition which seems to also have excessive, neurotoxic NMDA firing as a major feature underlying some of the sequelae ...
Click to expand...

That is so true, although I do overheat randomly throughout the day being stressed is a definete guarantee for me to get pretty feverish.....

This is somewhat emberassing to confess but I get very sick and feverish from sexual activity (something I try to avoid) and on many ocassions times I got so overheated from sex that I had to go to the emergency room at the hospital, although I didnt tell them what id been up to they found my tempearature quiet high and searched for signs of infection which they didnt find. This all started after the initial overdose which actually happened whilst I was having sex high on drugs and I think that aspect has played a huge role in messing certain areas of my brain and leaving me the way I am..... yes I overdosed on recreational drugs whilst having sex, you heard correct 8) *and the plot thickens*

But when you start saying things like "your overheating occurs in response to stress" it makes me feel like you understand me and perhaps you can solve whats hapening to me!?!
 
Last edited:
This might not be safe or effective advice but have you tried taking an antihistamine like benadryl before taking the pain meds?

This might not be a solution, and antihistamines potentiate the fuck out of the sedating properties of opiates which can cause more respiratory depression, but whenever I get an allergic reaction similar to yours, 50-100mg of benadryl takes it away in 25 minutes...

For some reason, Whenever I order Margaritas at a resturant or bar, I feel like someone dropped a litre of GHB in my drink. My breathing slows, throat closes, rash forms all over my chest, my body temp goes up and down and then I have a panic attack from all of those symptoms...Allergic reactions are scary as fuck..I couldn't imagine having one with opiates...
 
To be honest I havent tried any antihistamines mainly due to the fact I hadnt heard of them until recently, but I will give them a go if i can get the courage to trial the pinkillers again.

At the moment I have a few boxes of fentanyl patches left over , but im shit scared to have another adverse reaction . To be honest each time I have a bad reaction it feeels so severe I end up questioning wether I will live live through it. I so hate near death experiences after having so many of them, it gives me goosebumps just thinking about another one.
 
One can curb it, but some stress is unavoidable. A life spent avoiding it completely would be -- stressful, not to mention unrewarding. Social isolation is stressful, for instance.

I did read your previous posts as to when your problem started.

I am interested in the possibility that excessive NMDA firing (which does occur in a stress state, as well as with opioids in the VTA which causes a number of things to happen, and is ONE mechanism of neurotoxicity from amphetamine derivatives) is, if not necessarily a root cause, is responsible for many of your symptoms, or exacerbates them considerably in a matrix with other neurotransmitter/hormonal changes that occur following the fight-or-flight response. In this model, somehow your accident caused a serious regulatory fuckup and your stress response/sensitivity is exaggerated beyond belief. How this exactly happened is a thing apart -- what we MAY have is a way to combat something of it.

agmatine, another NMDA antagonist (endogenous): http://www.sciencedirect.com/scienc...serid=10&md5=2d307555b67d565241cd827cc076c9f5
 
Unlucky said:
To be honest I havent tried any antihistamines mainly due to the fact I hadnt heard of them until recently, but I will give them a go if i can get the courage to trial the pinkillers again.

At the moment I have a few boxes of fentanyl patches left over , but im shit scared to have another adverse reaction . To be honest each time I have a bad reaction it feeels so severe I end up questioning wether I will live live through it. I so hate near death experiences after having so many of them, it gives me goosebumps just thinking about another one.
Click to expand...


Maybe do a trail with a less potent medication...Fentanyl is strong enough alone to be scared that you're going to die%)

Try to get your hands on some semi-synthetic opiates...get some lortabs or some oxycodone.
 
BTW, another interesting thing to look at, along the lines of what others here have been talking about, is cyproheptadine (Periactin), available OTC in Canada, which is used with very high effectiveness in treating serotonin syndrome hyperthermia, and which is both a serotonin antagonist and an antihistamine.
 
Can you tell us more about your overdose? Which drugs did you take? What happened?
 
Status
Not open for further replies.
Top