I'm into pharmacology and that thought did occur to me, that perhaps in combination with gaba/opioid drugs it may worsen the slowed breathing caused by the latter two, and Google does show up several results. On their own though, NMDA antagonists interestingly do not have much of an effect on breathing rate. After I had surgery for a gunshot wound once (no kidding), when the Dr had redosed me with morphine 4 times, which was the limit for 4 hours, I told him I was still in pain and he IVd some ketamine, told me "A lot of people say it feels trippy". I use huge doses of DXM about once a month, and the k felt very similar unsurprisingly. A lot of the same halo like auras around everything and that distant but content, outside looking in feeling. Anyway, getting sidetracked. With regards to the subject of the thread from MY experience.. Yes vodka and meth, spaced out over 1 or 2 days with, say, 2 shots per hour, it can be great, alcohol in controlled doses virtually eliminated stimulant anxiety for me, but I am particularly reliant on GABA chems due to having asperger syndrome and an unspecified anxiety disorder. So I basically self medicate with ethanol, because in my area if you are younger than 50, you're chances of getting a benzo script are next to none, unless you are terminally ill or something, no joke. Ridiculous overreaction to the "opioid crisis", a loaded term in and of itself, and I'm speaking as someone who lost a cousin to a heroin overdose. In the end though, and while I miss him, the fact that he OD'd is honestly on him, there are ways to measure and even test for fentanyl. Fucking sucks I know, but I dont think anything should be banned because someone took it to far or did something outright retarded, rather producer or user, because that's usually the exception, barring suicides and intentional poisonings I suppose. Pragmatically, as long as opioids exist to one extent or another there will be overdoses, by definition. There are far more deaths annually from paracetamol (tylenol/panadol/you already knew that), which will never be pointed out in local news reports, because it's not tied to people getting high, so nobody cares. This culture makes no sense, to put it bluntly.