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About to make another poor decision for science

MOC maybe a RIMA but it also causes a significant pulse of prolactin after ingestion. It's so potent that it powerfully blunts every stimulant I've tried with it. Obviously this effect may vary for others.
 
I think it is a misunderstanding of ideology, or at least value placed on life, at some point I had a 'revelation' so to speak where I realized my life as a human and the achievements I built up are essentially worthless, I see people around me clinging on to something that will one day go away anyway, so why make yourself suffer through it all? Shaving a few decades of misery away only seems beneficial in my minds eye, and if it doesnt come to be, I'll have more time to enjoy myself. I really only see a victory here either way.

I guess it's part of our innate biology to value our lives and the lives of others but self awareness made me acknowledge these are just chains that bind us to a world of pointless suffering that we needlessly partake in because we are manipulated by our own instincts, essentially we are slaves tortured by our own minds for a pointless goal of reproduction and survival of which stems from the actions of pure entropy that resulted in our existence. Being alive is not a good thing innately, we're weird masses of electrical consciousness that were fished from the void and manipulated to fear its returnal, but we were given the gift of euphoria or the ability to feel good, and most importantly the ability to escape pain/suffering through death, in my mind both of these things are only positives

Even if some part of me is mentally convinced and factually acknowledges everything I am doing is wrong from a societal, moral and instinctive standpoint, spiritually I know I am doing something correct. I am using the tools granted to me here now to achieve what I think is the best I can grant myself as an observer, the highest form of sensory experience. Humans are very good at convincing themselves they're doing what's best for themselves. I would say, whatever brings most joy to oneself is the right thing to do, as long as you're not harming anyone else. You don't need to emphasize with my actions, know I only do things to enjoy myself with little else regard, and if I didn't like it I'd be doing something else. I'm really just like everyone else, trying to make ourselves feel better, whether its through charity, working hard, caring for others, or relentlessly abusing powerful substances to reach the peak sensory experience my mind is capable of creating, they are all actually quite similar.
Yeah, I do get that, and know that things be a struggle. Sorry if my previous comment came off as a lecture or abrasive or whatever, honestly it's from genuine concern for the community, you and others here.

I hope that given some time, you find that life isn't all suffering, or whatever, because, it really doesn't necessarily have to be like that, but I understand more than most, that sometimes people are *gifted* with a predisposition towards the struggle, through either genetics, or environmental trauma.

So, yeah I mean, I'm just gonna be honest about stuff like that, like most other members of the community here, because all of us have lost loved ones and members of this community. Truly I have no room to judge, and I have indulged in the craziest behavior one could possibly imagine, and had a self destructive streak for a very, very long time

Just be careful, dude.

If you ever need someone to vent to, I am always happy to listen.
 
MOC maybe a RIMA but it also causes a significant pulse of prolactin after ingestion. It's so potent that it powerfully blunts every stimulant I've tried with it. Obviously this effect may vary for others.
The most significant effect was a massive increase in the length of the peak, it's not a bam hit in your face that slowly weans down after 2-3 hours, the roll seems to steadily intensify over six hours massively, high also feels much more dopaminergic and stimulant where MDMA is generally actually a rather sedating drug for me, seems to change the effect into something a lot more pleasurable, I may get to try mephedrone soon on its own, could be what I'm looking for
 
Very interesting thread. Any noticabley different come down/after day effects?

While I would never encourage this combo, I do appreciate the report.
 
Very interesting thread. Any noticabley different come down/after day effects?

While I would never encourage this combo, I do appreciate the report.
Well, I didn't want to mention it, but I did the same combo yesterday, still feeling noticeable serotonin flood, normally about a week after I start feeling the zaps and in 3-4 days its back to normal, still feeling great. I've never really felt depression or such as a comedown from mdma moreso brain zaps which can be quite powerful and debilitating, small doses of DXM/kanna always cure it
 
Well, I didn't want to mention it, but I did the same combo yesterday, still feeling noticeable serotonin flood, normally about a week after I start feeling the zaps and in 3-4 days its back to normal, still feeling great. I've never really felt depression or such as a comedown from mdma moreso brain zaps which can be quite powerful and debilitating, small doses of DXM/kanna always cure it
Also interesting. Not scolding but just reminding (mainly to others) that it's generally not recommended to take MDMA multiple days in a row, but to each their own..

I've never had the zaps. Well maybe once from ketamine, cocaine, nitrous, and modafinil. That was a weird combo.
 
Also interesting. Not scolding but just reminding (mainly to others) that it's generally not recommended to take MDMA multiple days in a row, but to each their own..

I've never had the zaps. Well maybe once from ketamine, cocaine, nitrous, and modafinil. That was a weird combo.
Yeah, just wanted to finish it, wasnt much left anyway, im not touching the stuff for a long while

Also got mescaline hcl, 400mg total, rue combo should be safer with this one, will try this one out on the weekend. I recall my last experience eating the cactus lasting well over 16 hours so maybe not the best thing to take on a weekday

0W6ktwb.jpeg
 
Yeah, just wanted to finish it, wasnt much left anyway, im not touching the stuff for a long while

Also got mescaline hcl, 400mg total, rue combo should be safer with this one, will try this one out on the weekend. I recall my last experience eating the cactus lasting well over 16 hours so maybe not the best thing to take on a weekday

0W6ktwb.jpeg
Wow never seen mescaline in such a labeled professional form before. I am starting to see pressed pills occasionally and I've heard of gummies out there but I reckon they're big and taste gross.

The one thing I've heard about combining peyote with ayahuasca vine from someone who'sdone it several times, was that it noticeably more taxing on the heart...

The little warning sign with cactus is pretty dope.
 
Well, I didn't want to mention it, but I did the same combo yesterday, still feeling noticeable serotonin flood, normally about a week after I start feeling the zaps and in 3-4 days its back to normal, still feeling great. I've never really felt depression or such as a comedown from mdma moreso brain zaps which can be quite powerful and debilitating, small doses of DXM/kanna always cure it

Be vary careful thinking that the answer to the after-effects caused by one drug is best treated by taking MORE drugs.

It can be a slippery slope.

If you suffer unpleasent after-effects, that's your body telling you that whatever you did. you harmed it. Masking that does tend to lead down a path.

If your are suposed to be trying out an experiment, surely making people aware of the after-effects is a logical part of it all.
 
Be vary careful thinking that the answer to the after-effects caused by one drug is best treated by taking MORE drugs.

It can be a slippery slope.

If you suffer unpleasent after-effects, that's your body telling you that whatever you did. you harmed it. Masking that does tend to lead down a path.

If your are suposed to be trying out an experiment, surely making people aware of the after-effects is a logical part of it all.
True, but I understand the withdrawal is caused by downregulation of my serotonin receptors as a result of my body enacting homeostasis in response to too much serotonin, it's not that much different from how benzos downregulate gaba, you can technically 'taper it', but using MDMA for this is just causing more damage, small amounts of ssris seem to be a safe way to manage it which I've noted as quite effective, any depression or lingering effects seem to go away immediately after. Antidepressant withdrawal and MDMA withdrawal I have noticed are completely identical in effects, we know very little about how certain drugs affect the brain and the long term consequences of it, but if the recommended medically supported course for a withdrawal that feels identical is to taper with antidepressants, then I think I'm only doing myself a positive.

It's good to follow the rulebook of harm reduction, but avoiding exploring the unknown seems to be one of the rules that very much limit the ability for further understanding. Of course, I'm also just using this is an excuse to get high, but aren't we all...

The one thing I've heard about combining peyote with ayahuasca vine from someone who'sdone it several times, was that it noticeably more taxing on the heart...
Yea, that's definitely expected, one of the more noticeable effects from the mdma combination, but I must still say the palpitations and heart rate never came near to some of the experiences I've had on ritalin and methamphetamine alone, still the effect can be unpredictable so I will stick to the low side
 
I think people get overly hung up on the biological processes that MAY be responsible for a given side-effect.

But someone did make a glib comparison with the famous Timothy Leary quote - 'Turn up, tune out, turn up late for work on Tuesday' which as someone around the 80s-90s club/rave/free party scene, I understand.

Didn't Shulgin suggest not more than 1.5 mg/kg not more than once in any six week period?

I was lucky in that my friends were very concerned about my using even a diazepam to come-down. Some were older than me and I now realize probably had seen others moveron to harder stuff 'for the comedown' and were adament that a come-down was nature's way of telling you to SLOW DOWN.
 
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Yeah, feeling shitty after you come down is ultimately your body's way of saying it wasn't entirely a good idea, time to recover properly. Maybe we will choose to do it anyway sometimes, and maybe that's ok, but still. Our body tells us otherwise.
It's like with pain. We hate feeling pain but it's a very good biological response that tells you to keep your fingers out of the fire or out of the mouth of a lion.
I remember once having a physical problem with my leg, it really hurt, but I also wanted very badly to go for a tough hike in the woods, so I took some hydrocodone and the pain went away, and the hike was great. But then the next day the day was so bad that I ended up having to go the doctor. Likewise I have times I get high on whatever, feel crappy the next day and take something or the other to try to make it feel better. But objectively speaking, that doesn't really work out for the better. Fortunately, I have learned to moderate my response.
 
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At the end of the road, opioids treat both physical and psychological pain. A few people who just got Ed up at the weekend ended up using downers and then opioids. Then, slowly they wouldn't be going out every week but were still using the opioids.

You see where I'm going.

I am in no way saying it's a foregone conclusion, only that I know people who wend down that path and 30 years on, they have nothing and beg, borrow or steal just to stay well. Nightmare fuel.
 
The one thing I've heard about combining peyote with ayahuasca vine from someone who'sdone it several times, was that it noticeably more taxing on the heart...
Phenethylamines are predominantly potentiated by MAO-B, found in hordenine (can buy from supplement shops), just as a heads up.

@chris_p It's a wild experiment you pulled here, after some MAO-A inhibitors and HBWR seeds nearly killed me twice I stopped playing games with serotonin syndrome inducing bullshit. I'm glad that you kept the doses low and had a good time nonetheless. Trying to acquire a pharmaceuticaul with known serotonergic antagonism (like Trazodone) may be in your best interests given your proclivity for experiments that involve intense serotonin PAMs (positive allosteric modulators) like this. I'm curious too, what else have you mixed with MAOIs? I found mushrooms to be quite intense, and LSD to be the most rewarding by far.

The professional labeling of your bottle of mescaline is interesting to me, especially given that 400mg of HCl is approximately a single dose, I'm assuming it's sold as such due to the cost of production of a single dose?
 
Phenethylamines are predominantly potentiated by MAO-B, found in hordenine (can buy from supplement shops), just as a heads up.
This part is quite import, I only use rue which predominately works on MOA-A, serotonin related side effects were minimal although still somehwat potentiated

@chris_p It's a wild experiment you pulled here, after some MAO-A inhibitors and HBWR seeds nearly killed me twice I stopped playing games with serotonin syndrome inducing bullshit. I'm glad that you kept the doses low and had a good time nonetheless. Trying to acquire a pharmaceuticaul with known serotonergic antagonism (like Trazodone) may be in your best interests given your proclivity for experiments that involve intense serotonin PAMs (positive allosteric modulators) like this. I'm curious too, what else have you mixed with MAOIs? I found mushrooms to be quite intense, and LSD to be the most rewarding by far.
Yes, although I might get some criticism for it, I was hospitalised once in a similar combination, which was with DMT funny enough.. I was in no physical danger however. A large dose of rue (10g) before smoking changa, resulted in a very long lasting ego death for a few hours, i was completely blacked out due to it so my roommates thought I was overdosing, the mushroom combo I have also done several times I also took it with the MDMA in my last two combinations, the effect change is significant and more similar to DMT, less emotional/'wavy' headspace and it gets a lot more directly to the point, LSD i have not done much experimenting with much and I haven't done the drug many times on its own

Yeah getting some trazodone or seroquel could be a good idea but vendors dont exactly sell that stuff, might have to go speak to a doctor about it but doubt they'd give me any if I told them I needed it for tripping haha, I'd have to put up some schizo act. Xanax tends to do the trick but it definitely won't stop a physical overdose, I agree

The professional labeling of your bottle of mescaline is interesting to me, especially given that 400mg of HCl is approximately a single dose, I'm assuming it's sold as such due to the cost of production of a single dose?
All the products I get from my vendor are extremely professionally labelled, with mg dosing included for recreational use, also dosaging spoons and harm reduction sheets, the stuff I get from dispensaries are not even nearly as professional. I think it works through some kind of legal loophole where its sold for medical or herbal use as our country has laws for such a thing the reviews all mention drinking the bottle so thats my assumption, but how he gets to do it 'legally' with drugs like MDMA, ketamine, LSD, DMT, xanax I would rather not ask too many questions
 
Yeah getting some trazodone or seroquel could be a good idea but vendors dont exactly sell that stuff, might have to go speak to a doctor about it but doubt they'd give me any if I told them I needed it for tripping haha, I'd have to put up some schizo act. Xanax tends to do the trick but it definitely won't stop a physical overdose, I agree
You can always hit them with "A friend who has insomnia like me is prescribed a few a month for when the insomnia is particularly harsh. I've tried DXM, DPH, and chamomille tea but nothing seems to work. Would you be willing to try a few trazodones for the month?"
Doctors are aware of the dangers of DXM and DPH, and especially if you throw something innocent in like chamomille they'll usually fall for it. Trazodone has damn near zero abuse potential compared to things like Xanax anyways.
All the products I get from my vendor are extremely professionally labelled, with mg dosing included for recreational use, also dosaging spoons and harm reduction sheets, the stuff I get from dispensaries are not even nearly as professional. I think it works through some kind of legal loophole where its sold for medical or herbal use as our country has laws for such a thing the reviews all mention drinking the bottle so thats my assumption, but how he gets to do it 'legally' with drugs like MDMA, ketamine, LSD, DMT, xanax I would rather not ask too many questions
Where I lived for the last 3 years legalized all "plant-derived psychedelics", meaning that things like psilacetin and LSD were legal for sale at corner stores and the sort. When it's in that unregulated gray-market kind of place, you can get away with a shocking amount.
 
Starting feeling bad brain zaps yesterday night and this morning, much more severe than the usual.. took some tianeptine and kanna and it cleared almost instantly, feel even better than I normally do now. Not sure if this is putting a bandaid on the problem or I'm actually doing some kind of tapering here that's functioning very well.

Going to do the mesc combo tonight. Know I'm still a bit fucked up but I've got plans on the weekend and this stuff keeps me awake till 8 am, tonights the only night I'll have a chance to try it for at least a week. Will report back later
 
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