Opioids 7oh and suboxone

[helpingout]

its definitely not "much higher affinity"- its very close, (IIRC one was 0.25mg, the other 0.3x= 10mg morphine) and 7-oh is a stronger partial agonist than mitragynine.

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy - Nature Communications

Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalization of the C11 position of MG, and show that...

www.nature.com

I have felt kratom doses while taking subs

 

[Quasimoto]

I have felt kratom doses while taking subs

They are referring to 7oh and mit affinities.

There are so many different alkaloids in kratom, a lot of which are promiscuous and hit many receptors.

I, too, feel a bit of stimulation and dopamine tickling from kratom while on subs. But 7oh doesn't do much until the bupe isn't crowding my receptors.

 

[LSDiesel]

I wonder if it could outcompete and deplace methadone, or if anything does other than bupe, fentanyl and nitazenes

 

[notsmokeymcpot42088]

I would not test it just in case it does. Methadone is a full agonist = better (euphoria wise) than 7oh, bupe, (Imo fent and ntazenes too) Although I have never and likely never will try a nitazene other than in the grey death they are sellin as H.... I prefer a rec dose of done' to Fet all day --- however fent tends to break through methadone does not.

Have you checked the binding affinity of each? Should give a rough idea

 

[Kurt Cobain]

I have read that yes you can PWD going from 7oh to sub and basically experience wise from people I have faith in, no not worth competing with or jumping off sub for a day to use. 02 cent peanut gallery opinion

Not really. I've done it plenty of times. I've taken subs two hours after last dose of 7 and I was taking 400mg a day if not more. Zero issues but jusy so yall know suboxone does not fucking help high dose 7oh withdraw like at fucking all.

 

[Quasimoto]

uboxone does not fucking help high dose 7oh withdraw like at fucking all.

I know your pain, but it does help.

It just sucks because it doesn't cover all the symptoms... and then when you have suboxone in your system, you can't take more 7oh because it blocks it. So you're stuck in this state which is similar to precip withdrawal, but it's not precip withdrawal.... but it is in a way... I gets its precip withdrawal without the precipitation... idk

I find that I recover rather quickly, and after about 2 days I feel normal on subs again.

It's also crazy how quickly I develop withdrawals from 7oh. After just 2-3 days taking high doses of 7oh instead of my suboxone, I will get nasty withdrawals.

 

[Kurt Cobain]

I know your pain, but it does help.

It just sucks because it doesn't cover all the symptoms... and then when you have suboxone in your system, you can't take more 7oh because it blocks it. So you're stuck in this state which is similar to precip withdrawal, but it's not precip withdrawal.... but it is in a way... I gets its precip withdrawal without the precipitation... idk

I find that I recover rather quickly, and after about 2 days I feel normal on subs again.

It's also crazy how quickly I develop withdrawals from 7oh. After just 2-3 days taking high doses of 7oh instead of my suboxone, I will get nasty withdrawals.

It doesn't help me in the slightest and I truly do mean at all even paired with normal kratom powder. You also can take 7oh along side subs and still feel full effects albeit a bit dulled. I'm also not on sub maintenance and it sounds like you are so that could change things. I do get withdraw very quickly from 7oh though one day of moderate usage I'm feeling off the next day but two days and I'm having full blown withdraw, could be kindling eggevts but I believe it's just the nature of 7oh. It's a dirty ass drug especially the unrefined tablets.

 

[Kurt Cobain]

I know your pain, but it does help.

It just sucks because it doesn't cover all the symptoms... and then when you have suboxone in your system, you can't take more 7oh because it blocks it. So you're stuck in this state which is similar to precip withdrawal, but it's not precip withdrawal.... but it is in a way... I gets its precip withdrawal without the precipitation... idk

I find that I recover rather quickly, and after about 2 days I feel normal on subs again.

It's also crazy how quickly I develop withdrawals from 7oh. After just 2-3 days taking high doses of 7oh instead of my suboxone, I will get nasty withdrawals.

Only thing that helped 7oh withdraw was high dose MIT extracts and gabapentin with some benzos and kratom powder a little bit but ymmv I was at my peak at about a gram a day of the shit

 

[notsmokeymcpot42088]

a gram a day? So you may be dealing with w/ds from roughly 23g of morphine a day. (23x potent in mice, now that seems to not translate to humans but the w/d still might?)