Opioids 7oh and suboxone

[aesthetic.addict]

Very low, maybe 2-3mgs per day for a few days when I was trying to kick the 7oh. I'm personally pretty sensitive to subs blocking effect, very small doses block me for a couple days. I get nothing from taking large doses of subs beyond what 2-3mg can produce so I always keep it low cause I'd jusy be wasting it. They were the films though and tbh I know people say there is no difference between brands but these ones suck or suboxone is just terrible at helping with 7oh wd. Currently going through a 7oh kick again worked my way up to damn near a gram a day of 7oh and took some sub yesterday as it was the first day off and it did absolutely fuck all. Gabapentin and 5mg Valium mixed with 1mg Xanax did much much more to help me than the bupe which I think is weird as fuck.

Oh okay I see. Probably wont be worth taking any oxys then. I've been on it a year now, started tapering from 28mg 3 months ago, I'm at 6mg now.
Ah yeah that's wierd, good that you had the other stuff to help

 

[Kurt Cobain]

Oh okay I see. Probably wont be worth taking any oxys then. I've been on it a year now, started tapering from 28mg 3 months ago, I'm at 6mg now.
Ah yeah that's wierd, good that you had the other stuff to help

Definetly not worth taking/buying the oxy. I'm also back on kratom again which imo has a blocking effect all on its own but no science to back it up it just feels like it blocks other opiates unless it's strong H which I don't fw anymore. I'm out of benzos only had enough for one day sadly but gaba is helping and still debating on taking some sub. I haven't had it in weeks aside from the few mgs I took yesterday that did nothing

 

[Kurt Cobain]

Yep, a couple of times I had jumps so bad it felt almost exactly like the beginning of audiogenic seizures I've had during alcohol withdrawal. I mostly get it from pseudo, or if I combine high doses of mit with cannabis. I don't get it that much from 7oh, it still occurs but not nearly as bad as the other 2.

I haven't dabbled with pseudo too much, I had it in the green pressed pills but it just made me feel weird and those are also mixed with 7oh idk wasn't a fan of the pseudo so never looked for actual good powder. What are or were your doses of 7oh in a day if you don't mind me asking? The 7oh makes me twitchy towards mid day after a few doses even at lower doses but much much more pronounced with higher doses. Shits dirty and fiendish as fuck due to the short ass half life

 

[Kurt Cobain]

Somewhat. Pseudo is about 2x more potent by dose than 7oh. More stimulating as well. But it also lacks the warmth that 7oh provides. It feels a bit cold and mechanical by itself.

I always preferred combining them to get the best effect.

Exactly why I didn't like pseudo, kinda made me feel disassociated and like u said cold like fentanyl compared to H

 

[Skorpio]

Good luck man, the first day is the worst but it gets a lot easier fast. The cravings are pretty bad but if you really want to get clean it won't be too bad. Also the powder can help especially since you're at such a low dose but high purity MIT extracts work better. If you want to be off everything, I'd say steer away from kratom and any of its alkaloids and grab some gabapentin if you can

The first 2 days were pretty feverish, and I’ve been using Benadryl for sleep, but it’s been surprisingly mild, and I honestly feel less mentally fucked than previous experiences with extracts.

 

[Kurt Cobain]

The first 2 days were pretty feverish, and I’ve been using Benadryl for sleep, but it’s been surprisingly mild, and I honestly feel less mentally fucked than previous experiences with extracts.

I'm on day 2 myself right now and it's not terrible, cravings are hitting really hard right now though. I'm suprised you're using benadryl, it always makes me so fucking restless while in wd. Keep going though man and remember the hell this dirty ass drug as caused next time u feel like picking up

 

[Quasimoto]

I haven't dabbled with pseudo too much, I had it in the green pressed pills but it just made me feel weird and those are also mixed with 7oh idk wasn't a fan of the pseudo so never looked for actual good powder. What are or were your doses of 7oh in a day if you don't mind me asking?

The stuff in press'd isn't real pseudo. It's one of those brands that has a COA which misidentifies one of the 11-OH analogs, calls it pseudo, but it's not. Those pills are dirty, leftover solvent. Gives me instant headaches, high body temperature/sweating, and weird concerning numbness... like I ate acetone or methanol or something.

The only brand I know of putting out real pseudo atm is Hydroxie. But those pills are also dirty... gives me liver pain and swelling, and a hepatic rash which caused scarring on my skin.

Most of those retail branded pills are dirty as fuck. Shoddy chemistry. The ONLY brand I've tried which is clean is the original 7ohms and certain online powders.

Anyways, my last misadventure with 7oh I was taking about 300mg per day. I was going through grams of 85% 7oh powder in about 3-4 days. On top of regular mit and some real pseudo. That's a stupid amount, I was only taking that much because my tolerance was ridiculous. Frankly, there is no reason to ever go more than 50mg per day, it only creates extreme diminishing returns and a wicked withdrawal.

 

[Kurt Cobain]

The stuff in press'd isn't real pseudo. It's one of those brands that has a COA which misidentifies one of the 11-OH analogs, calls it pseudo, but it's not. Those pills are dirty, leftover solvent. Gives me instant headaches, high body temperature/sweating, and weird concerning numbness... like I ate acetone or methanol or something.

The only brand I know of putting out real pseudo atm is Hydroxie. But those pills are also dirty... gives me liver pain and swelling, and a hepatic rash which caused scarring on my skin.

Most of those retail branded pills are dirty as fuck. Shoddy chemistry. The ONLY brand I've tried which is clean is the original 7ohms and certain online powders.

Anyways, my last misadventure with 7oh I was taking about 300mg per day. I was going through grams of 85% 7oh powder in about 3-4 days. On top of regular mit and some real pseudo. That's a stupid amount, I was only taking that much because my tolerance was ridiculous. Frankly, there is no reason to ever go more than 50mg per day, it only creates extreme diminishing returns and a wicked withdrawal.

Ya you can taste the left over solvents in most of the retail pills and even more feel the negative effects immedeatly. I had all the same symptoms starting with the pills but it followed me with the powder as well. 7oh is just a dirty drug in general. It wouldn't be near as bad imo if they had a long acting form

 

[Kurt Cobain]

The stuff in press'd isn't real pseudo. It's one of those brands that has a COA which misidentifies one of the 11-OH analogs, calls it pseudo, but it's not. Those pills are dirty, leftover solvent. Gives me instant headaches, high body temperature/sweating, and weird concerning numbness... like I ate acetone or methanol or something.

The only brand I know of putting out real pseudo atm is Hydroxie. But those pills are also dirty... gives me liver pain and swelling, and a hepatic rash which caused scarring on my skin.

Most of those retail branded pills are dirty as fuck. Shoddy chemistry. The ONLY brand I've tried which is clean is the original 7ohms and certain online powders.

Anyways, my last misadventure with 7oh I was taking about 300mg per day. I was going through grams of 85% 7oh powder in about 3-4 days. On top of regular mit and some real pseudo. That's a stupid amount, I was only taking that much because my tolerance was ridiculous. Frankly, there is no reason to ever go more than 50mg per day, it only creates extreme diminishing returns and a wicked withdrawal.

It's extremely morish due to it wearing off so fast and idk about you but it gives me a brutal come down, like I can feel the very second my levels drop and when that happens I get a mad rush of anxiety, even stim comedowns don't hit as bad as 7oh imo but I also have adhd so that could play a role

 

[notsmokeymcpot42088]

Think I am gunna go down to 1 mg flat bupe for a few days than taking a decent dose. First hand trip report to come - I will attach it to the other 7-oh trip report I wrote on behalf of someone in actual pain

 

[Quasimoto]

Think I am gunna go down to 1 mg flat bupe for a few days than taking a decent dose. First hand trip report to come - I will attach it to the other 7-oh trip report I wrote on behalf of someone in actual pain

On 2mg of bupe, I don't feel anything from 7oh, even very high doses, unless I wait about 30 hours minimum after my last dose. After about 40 hours I can nod on 7oh if I take a high enough dose, but it was still significantly blunted.

Just FYI. Also, after doing this for 4 days out of a week (went through about 400-500mg of 7oh), I got a nasty rebound withdrawal, and not even 8mg of subs made me feel normal. Don't go crazy with it.

 

[notsmokeymcpot42088]

Grazi --- For all of the questions of mine you answered! Im thinking not for me, throw them with the kratom in the "when" pile.

Very useful to know. Keep handin em out to old folks instead. (and of course by handing out i mean informing them where to obtain/going with etc w/e). When it was likened to heroin and oxycontin I got a bit excited. Also oxy does not seem to break through sub well at all. (as if ya'll didnt know)

 

[aesthetic.addict]

How high dose of bupe are you on @notsmokeymcpot42088 and how high was the oxy dose?

 

[notsmokeymcpot42088]

1 - 2 mg a day (little more than one little less than 2) oh when I was doing the oxy duh --- 2 - 4 mg with a 24 to 30 hour break and the dose of oxy didnt matter much I got up to about 80 before deciding I couldnt afford to keep throwin money like that.

 

[LSDiesel]

Please forgive me if it’s answered in this thread but I couldn’t find a definitive answer. So 7oH will outcompete bupe? As in knock bupe off MOR in your spine and brain? But only for some? Or is the thought that it is the pseudo which is more responsible. Could a precipitated withdrawal be fixed by taking these Kratom alkaloids in the event of initiating bupe say if one was dependent on morphine or methadone or Kratom of course?

I never thought about it but getting a good rush or a good “high” is kind of like the opposite of precipitated withdrawal it’s like going from sober to accelerated pain relief with an orgasmic chaser.

Of course we all know THE BEST rush is the one that travels from down in the dumps sickness bottom all sweaty and symptomatic transformed in a virtual eye blink (a few moments) to feeling so good you might crack a smile or set out to accomplish something like tackling some demanding work or chores with a swagger and an internal soundtrack playing to the tune of your own rhythm.

 

[notsmokeymcpot42088]

I have read that yes you can PWD going from 7oh to sub and basically experience wise from people I have faith in, no not worth competing with or jumping off sub for a day to use. 02 cent peanut gallery opinion

 

[LSDiesel]

I have read that yes you can PWD going from 7oh to sub and basically experience wise from people I have faith in, no not worth competing with or jumping off sub for a day to use. 02 cent peanut gallery opinion

Ok but then can you just dose more 7oH as 7oH binds even more competitively than bupe and will outcompete it, right? This could be game changer if 7oH can can cancel a precipitated withdrawal due to bupe or naloxone or naltrexone. If precipitated withdrawal occurs which no one is in dispute no one would mistake for some other type of illness or reaction, it means that administering some substance had a cascading effect of knocking off many opiates at once from being on your mu opiate receptor sites actively to having the receptor sites be occupied by something that antagonizes opiate effect or possibly partially antagonizing it usually while simultaneously partially agonizing it hence the term partial agonist/antagonist .

Is 7oH a full agonist, I thought it was. Is it a partial ?

 

[pcplease]

its been a decade since i read up but i thought kratom as a whole was a partial agonist/antagonist, and that 7-oh did bind stronger than bupe

 

[Quasimoto]

I have read that yes you can PWD going from 7oh to sub and basically experience wise from people I have faith in, no not worth competing with or jumping off sub for a day to use. 02 cent peanut gallery opinion

In my experience, no. Subs do not cause PWD from any kratom alkaloids. They just don't totally cover the withdrawal for some reason.

I switched from ridiculous doses of 7oh and immediately started subs, didn't wait at all, and didn't have any precip at all. I was still having some minor withdrawal symptoms for 4 or 5 days, mainly because my bupe dose was too low, but nothing like precip withdrawals.

So 7oH will outcompete bupe? As in knock bupe off MOR in your spine and brain?

No, it does not.

Bupe has much higher affinity at MOR. In fact, 7oh has lower MOR affinity than mitragynine itself.

I need to wait 30 hours minimum after a dose of subs to feel anything at all from any kratom alkaloids, including pseudo. Subs block them.

 

[pcplease]

its definitely not "much higher affinity"- its very close, (IIRC one was 0.25mg, the other 0.3x= 10mg morphine) and 7-oh is a stronger partial agonist than mitragynine.

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy - Nature Communications

Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalization of the C11 position of MG, and show that...

www.nature.com