Also, I'm curious as to what can be said about the neurotoxicity of this compound on it's own. If I recall correctly 2-fma does not release serotonin.
I believe, 2-FMA indeed binds to SERT. In order to underline my statement I've collected some info from papers regarding the effects of X-F(M)A's.
I've made a comparison chart with gathered scientific data coupled with personal experience.
Unfortunately, I cannot say anything to the in vitro potency of 2-FMA but I tried to derive data from experience in the end.
Would be great if someone could complement the summary with data for 2-FMA.
potency expressed in mean of self-administered dose in mg per kilogram body weight (tested on apes), that is sufficient as cocaine replacement:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4-FA
0.32
3-FA
0.23
Meth-A
0.10
In vitro potencies of inhibition of monoamine uptake in nano-moles (the lower the stronger) :
-------------------------------------------------------------------------------------------------------------------------------------------------------
4-FA
DA : 33.3, NE : 18.3, 5-HT : 218
3-FA
DA : 24.2, NE : 16.1, 5-HT : 1937
Dextroamph
DA : 8.0, NE : 7.2, 5-HT : 1756
Meth :
DA : 4.67, NE : 6.47, 5-HT : 116
LD_50s of fluoroamphs vs. amph in mice :
--------------------------------------------------------------------
2-FA
100mg/kg
4-FA
46mg/kg
d-methamphetamine
55mg/kg
d-amphetamine
98mg/kg
Correlations between experience and scientifically obtained effects profile (speculation) :
4-FA :
Is far less potent but has a worse LD50 than d-Amph and d-meth -> overall higher toxicity. For me it also feels very draining the next day (if more than 80mg is consumed).
4-FA has half of the potency of Meth regarding 5-HT reuptake inhibition. The DA/5-HT-ratio of 0,15, which is the highest in the above data, underlining it is better suited for social settings
than any of the other compounds. 4-FA is the most similar compound to Meth of the above, if you can say that, because DA inhibition it lacks significantly.
3-FA :
3-FA is less potent but has a similar effect on monoamine reuptake as d-Amph. If you just take the above data into account, the effects shall be the same as d-Amph with a slightly better DA/NE-ratio, meaning less jittery, but a slightly worse DA/5-HT-ratio, meaning supposedly more head fog but perhaps the activity on 5-HT is too weak anyway. Also 3-FA was considered the most effective cocaine replacement of every substituted amphetamine (including meth and d-amph). That means that it is highly addictive/moreish.
Meth :
Is somewhat outstanding, as the DA/NE-ratio is <1 (more dopamine, less norepinephrine) . That would explain the absence of side effects, that users describe and also the addiction potential. The pretty high DA/5-HT-ratio could also be a contributor for that. The high DA/5-HT-ratio is responsible for the depression when in withdrawal.
2-FMA :
Is not mentioned above. But I guesstimate from the effects that its profile is something like that :
2-FMA
DA : 20, NE : 16, 5-HT : 750
For my taste there is too much serotonine action going on, making the effects unpredictable. Also it has completely different effects if you change the ROA. Insufflated it is okay, but orally
it has too much SRI - qualities ! Please correct the data, if there are errors. If you can provide data on 2-FMA, it would be great.