Jabberwocky
Frumious Bandersnatch
How deep you should insert your gelcap or syringe to squirt your drugs depends a little bit on which drug and whether you want to avoid first pass metabolism by the liver.
The higher end of the colon will transfer drugs into the portal vein system which in turn drains into the hepatic system and liver.
The lower end of the colon transfers drugs to the iliac vein system part of which drains directly into the femoral vein, bypassing the first pass metabolism.
The first pass metabolism (if hepatic) will reduce the bioavailability of your plugged drug (eg valium).
Some drugs are pro-drugs that actually need to be metabolised by the liver because it is the metabolite that is psychoactive (codeine —>morphine)
The higher end of the colon will transfer drugs into the portal vein system which in turn drains into the hepatic system and liver.
The lower end of the colon transfers drugs to the iliac vein system part of which drains directly into the femoral vein, bypassing the first pass metabolism.
The first pass metabolism (if hepatic) will reduce the bioavailability of your plugged drug (eg valium).
Some drugs are pro-drugs that actually need to be metabolised by the liver because it is the metabolite that is psychoactive (codeine —>morphine)