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NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports

Hi, my first post here, so my apologies if this has been covered already. I've read the majority of the 19 pages of this thread but not absolutely every post. Anyway, I'm wondering about using DXM to reduce tolerance to 4-fa and 4-fma. I'm assuming that these are similar enough to amphetamine that the effects should be similar. Here's what I'm taking:

every day:
B vitamins
CO-eQ

most days:
aniracetam (between 300 and 700 mg per day)
choline (300 mg)

What I'm trying now:
Delsym - around 45 mg
magnesium - 250 mg
green tea extract
4-fa or 4-fma or combo: around 40-70 mg - not every day, about 2-3 times per week - mostly oral with some intranasal

I'm wondering if this will be effective.

Most importantly, I'm wondering what NOT to take on DXM. I've never used it recreationally. However I do like to occasionally take 4-mec, methylone, 2c-d, 2c-c, and methoxetamine.

Since DXM releases serotonin (it does, right?), but since this is a very low dose (45 mg) do I still need to avoid all of the above rcs, and if so, for long do I need to avoid them for? because tonight I figure I'll probably want to do around 10-15 mg of methoxetamine if possible.

Thanks in advance!
 
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alienidentikit said:
Most importantly, I'm wondering what NOT to take on DXM. I've never used it recreationally. However I do like to occasionally take 4-mec, methylone, 2c-d, 2c-c, and methoxetamine.

Since DXM releases serotonin (it does, right?), but since this is a very low dose (45 mg) do I still need to avoid all of the above rcs, and if so, for long do I need to avoid them for? because tonight I figure I'll probably want to do around 10-15 mg of methoxetamine if possible.

Thanks in advance!
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Yes I was thinking of the risks to mix MDPV and DXM, to ease the comedown, decrease the skyrocket tolerance. Did somebody tried this? I'm afraid by the increse risk of high pressure problem.

I mixed like 100mg of DXM on an MDMA end trip without much problem (but I don't say that this mix is safe! It NOT safe!). I mixed low dose DXM (30mg) with mephedrone or methylone too and I'm not dead, but I can't say if it was benefitiall.
 
alienidentikit said:
Hi, my first post here, so my apologies if this has been covered already. I've read the majority of the 19 pages of this thread but not absolutely every post. Anyway, I'm wondering about using DXM to reduce tolerance to 4-fa and 4-fma. I'm assuming that these are similar enough to amphetamine that the effects should be similar. Here's what I'm taking:

every day:
B vitamins
CO-eQ

most days:
aniracetam (between 300 and 700 mg per day)
choline (300 mg)

What I'm trying now:
Delsym - around 45 mg
magnesium - 250 mg
green tea extract
4-fa or 4-fma or combo: around 40-70 mg - not every day, about 2-3 times per week - mostly oral with some intranasal

I'm wondering if this will be effective.

Most importantly, I'm wondering what NOT to take on DXM. I've never used it recreationally. However I do like to occasionally take 4-mec, methylone, 2c-d, 2c-c, and methoxetamine.

Since DXM releases serotonin (it does, right?), but since this is a very low dose (45 mg) do I still need to avoid all of the above rcs, and if so, for long do I need to avoid them for? because tonight I figure I'll probably want to do around 10-15 mg of methoxetamine if possible.

Thanks in advance!
Click to expand...

I second that. I have just started taking DXM to prevent tolerance to opiates and desoxypipradrol and I need to know which drugs to keep away from while taking DXM. Could anyone show a list?

What about MDAI for example, I would love to try it, but I obviously won't if it's unsafe :)
 
Generally every drug that interacts with serotonine, tramadol, mdma, mdai, SSRI's etc, then youd be safe.

I didnt notice anything special from combining theanine with DXM, perhaps with some amp it would be better, anyone added some other drug to that combo?

I do take a bunch of other supplements tough, giving some stuff a try.
 
This week I've started dxm HBr 60mg twice per day which I will be doing for two weeks before trying MDMA. Last night I had K but was unable to k hole. Is there any chance that the DXM could have prevented it? I'm not taking anything else at the moment.
 
Damned, dont know what to do when ppl arent responding on the internet, allways start rambling shit with my adhd mind.
 
chaos_destroy said:
This week I've started dxm HBr 60mg twice per day which I will be doing for two weeks before trying MDMA. Last night I had K but was unable to k hole. Is there any chance that the DXM could have prevented it? I'm not taking anything else at the moment.
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Yes, the metabolite can stay around for a few days.
 
MeDieViL said:
I didnt notice anything special from combining theanine with DXM, perhaps with some amp it would be better, anyone added some other drug to that combo?
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Marijuana. Green tea or black coffee. I might experiment adding LOW doses of ondansetron, acamprosate, or tianeptine to this combo, although I'd make damn sure I was not at a greatly increased risk for serotonin syndrome.
 
I recently entered my diet into a nutrition program and found out my magnesium and zinc intake was pathetic. It's been 2 weeks now since I started taking it and I feel incredible. I almost believe my anxiety and depression was all a mineral deficiency. I never noticed antidepressant effects from dextromethorphan. Is there another mechanism beyond NMDA receptor modulation that zinc and magnesium effect mental illness?

I'm also looking forward to seeing how my tolerance is effected. Something tells me it might be better than DXM.
 
MyDoorsAreOpen said:
2 weeks going strong on 60mg DXM, 200mg Suntheanine, and 2 shots of black espresso to start my day. I am very impressed. I'm a third year medical student on my surgery rotation, which is far and away the most demanding thing I've ever done. I am motivated, can-do, and emotionally stable like never before. I never thought I could muster such calm and such such productivity at once. I don't take anything any asshole doctors say personally, which is something I used to have a real issue with that I couldn't will away.

I am almost certain now I will never touch amphetamine again. This is increased dopamine and serotonin tone the way my body naturally sets it, differentially. Adderall, on the other hand, was turning all the DA neurons in my body up to 11. Why tolerate the shitty comedown and side effects, when I can get enough neurostimulation to improve my life without any side effects!

I also have no taste for alcohol at all on this regimen. I know I will have it socially now and then, but I can honestly say it wouldn't kill me to never have it again.

The only downside I've noticed (especially on my job!) is a MILD memory impairment. But the tolerability of the toil is worth the trade off for sure.

I'm going to try Delsym next week and see if it's better, as a time-released prep with a longer duration, no bromine, and more conversion to DXO.
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I find it interesting it helps with your adhd (or are you taking it just for motivation?).. I tried some yesterday eve and this morning, and as a result I slept bad and have been feeling groggy all day.. I feel weak, but I worked out fine today. I wonder if these side effects will go away when I take it consistently, but I am reluctant to try it out, because I really feel like shit.

methylphenidate is giving me erectile dysfunction though so it seems I'm really fucked.
 
The next substance il put some work is gonna be ibogaine, while memantine is excellent for tolerance related issues, there are still some issues left untreated namely addiction, withdrawals and mental addiction with certain substances, ibogaine may have some very interesting potential here, its more known for curing heroin addicts, but you gotta trip on it wich may limit its potenial, however less well known it can also be used in daily small doses for (intermittent) periods.

Such therapeutic possibility's have undeniably a tremendous therapeutic potential, investigating all available documentation and bringing this to a group of people that can benefit from this substance is thus warranted.
 
how much DXM do i need to consume to adequately antagonize my NMDA receptors enough to reduce tolerance?

60mgs? 100mgs? 200mgs?
 
damn that might be a little hard to remain sober that long hahah.. i was hoping 3-4 days....bleh but tolerance does blow...decisions, decisions....
 
Has anyone else effectively used memantine to successfully lower tolerances? I have seen anecdotal reports, but when I did it I had a bad experience. I think I increased my dosages too quickly (I worked myself up to 40mg daily within a week) and I got this pseudo-psychedelic mindset and horrible respiratory depression
 
well you could try it 20mg at morning 20 in the evening for 4 days, should also have some effect, just try it out and report :)
 
I had to work myself up to the 40mg. I started at 10mg. The half life is really long, so maybe it was accumulating. I really don't think I'll try it again. Towards the end I was getting paranoid and terrified
 
^^damn you get paranoid at 50mgs? mind over matter my friend....

Torabora said:
well you could try it 20mg at morning 20 in the evening for 4 days, should also have some effect, just try it out and report :)
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haha you stole the words right out of my mouth, except tthis time im using around 75mgs dxm once per day....
 
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