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NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports

Saber44 said:
I had to work myself up to the 40mg. I started at 10mg. The half life is really long, so maybe it was accumulating. I really don't think I'll try it again. Towards the end I was getting paranoid and terrified
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My second try With memantine wasnt the same That the First Time. Me and my girlfriend were getting paranoïde With strange effects in the heart (i think linked to stress). Opiates werent nicely potenciates l'
Like before. Maybe a low quality memantine...
 
I stopped using memantine because of the respiratory depression. DXM is a far safer way to go. I just wish Delsym wasn't so expensive. 15 dollars for a big bottle that will last like a week and a half!

I still have tons of memantine lying around... I have a feeling I'm going to need both. My doc decided just to cut me off cold turkey from 20mg of Valium a day and I have about 200 1mg Kpins stored away so I think I'm going to switch to .5 twice a day and I'm also going to do 60mg of Delsym twice a day.

I just wish I could use the regular cheap cough syrup *sigh* Anyone know when the polisterex patent expires?
 
Currently i take curcumin an NAC to see their effects on drug tolerance 1 mate confirmed nac reversed some benzo tolerance another one says curcumin and nac prevent tolerance to bupe and from my own limited experience i only saw a decline in ritalins effects when i ran out of nac witch nac reversed again curcumins modulation of creb synergizes with this.

Combined with the fact that those are the most health benefitting supplements available and having a nac supply around is good as a acute high dose can prevent psychosis when you feel one coming up.
 
So, has anyone been doing this at proper doses for over a year straight?

I really wonder about the long term damage and effect on personality developement. But most of all: Can tolerance be kept at bay for years or do the NMDA-antagonists just add to the drug craze, having to add more and more throughout time? I know you can develope a massive tolerance to the behavioural effects of Ketamine and PCP which lasts forever and a day.

NMDA receptors are pretty wicked and critical for neuronal plasticity and they are all over the brain. I'm not sure if we can keep blocking them successfuly, my attempts to use any of these drugs for a long time never lasted more than 3 months.
 
Are there any rodent student with chronic lifelon nmda inhibition?

Tolerance away forever? currently doubt it at points youd need breaks

I used to take 80mg mem for a while and later found even 10 mg still makes a major difference but its people and drug dependent

NAC is a perfect modulater for the nmda system imo restores neuroplasticity after pcp one of the million benefits

But well see how it stacks up to memantine long term definatly abolisher of bad comedown effects togheter with curcumin.
Didnt notice any crash or tolerance the last few days of using ritalin in my regime but its still to early to say shit about it.
 
Holy shit. I don't know how you guys were able to use 80mg memantine.
Off of 40mg I was getting dangerous respiratory depression, and some absolutely insane depersonalization/derealization. I remember walking through my house and not recognizing it. I also remember always having the feeling when I was home alone that no one would ever come back and I would only be alone. On the last night of my memantine I wrote this insane, little gem...

"Before I begin I feel i should assure any readers that these theories/off-the-wall hypothesis were conceived in a perfectly normal, stable mindset. It is not often that I have strokes of insight that I actually feel obligated to share, but when I do I feel i should do so in it's entirety.



So, maybe I'm just crazy, but does anyone else ever entertain the idea that maybe the lives they are living aren't lives at all. Could it be, instead, a dream? Yes, It is possible. Ponder this- what if the live you lived everyday was just a subconscious dreamlike projection of yourself while your physical/corporeal body is injured/comatose/otherwise incapacitated. Assume this is true, and re-look over everything in your life. Think about how time would be perceived if your real life was actually a dream. Your childhood memories and adolescence would, in reality, have happened in the span of a few hours. You wouldn't even know the difference because of how your subconscious would cope to assure yourself it was real.



Now imagine waking up from this dream. All these experiences, perceptions, emotions, would be gone in the space of a few minutes. You would cling fast to the reality of your dream world, but in the end, it would still be just that- a vivid dream.



humor me. Take it a step farther. Assume you don't have a physical body. Assume for all intents and purposes you are deceased, and the life you are living now is just a reality created by your mind, which is no longer burdened by the task of controlling life functions. It is now free to roam at its leisure and push it's limits. Assuming this is true, other people in your world would be one of two things.

First, they could be the imprints of past people/experiences/lives you have lived or come in contact with. The people would have left enough impression whilst they were living to warrant a spot in your dream world. So when you think about it, even the most insignificant of people in our worlds (both real, or dream, however you are currently perceiving them) has some sort of priceless worth.

Secondly (and personally I entertain this idea) that the dream world we live in is the result of minds leaving physical bodies upon death. No longer bound by the restraints of physical bodies, the minds are left to wander freely and they eventually end up in one collective conscious (the "dream world"). If you have humored me thus far, do so a bit more and assume that the "dream world" is nothing more than a collective conscious- "Afterlife" if you will. Heaven and hell would have no distinction in the dream world simply because the both exist in the same reality. The choice as to what side we stray to would rest solely in the individual (which could be refutable which my earlier mention of a collective conscious). So basically, the "dream world" (IE death) would be indistinguishable from actual life except for the perception of time, which would be irrelevant assuming that the "dream world's" flow of reality was never interrupted (For example, the person waking up/coming out of a coma, etc). If you assume both are one in the same, then you know in your heart that you shape your destiny. Heaven nor Hell is predetermined, but is instead a path the users chooses to walk along.



Maybe I was just rambling. I, Myself, can see the linear progression of ideas here in what I posted, but some of you may not, which would be understandable."
 
Saber44 said:
Holy shit. I don't know how you guys were able to use 80mg memantine.
Off of 40mg I was getting dangerous respiratory depression, and some absolutely insane depersonalization/derealization. I remember walking through my house and not recognizing it. I also remember always having the feeling when I was home alone that no one would ever come back and I would only be alone. On the last night of my memantine I wrote this insane, little gem...

"Before I begin I feel i should assure any readers that these theories/off-the-wall hypothesis were conceived in a perfectly normal, stable mindset. It is not often that I have strokes of insight that I actually feel obligated to share, but when I do I feel i should do so in it's entirety.



So, maybe I'm just crazy, but does anyone else ever entertain the idea that maybe the lives they are living aren't lives at all. Could it be, instead, a dream? Yes, It is possible. Ponder this- what if the live you lived everyday was just a subconscious dreamlike projection of yourself while your physical/corporeal body is injured/comatose/otherwise incapacitated. Assume this is true, and re-look over everything in your life. Think about how time would be perceived if your real life was actually a dream. Your childhood memories and adolescence would, in reality, have happened in the span of a few hours. You wouldn't even know the difference because of how your subconscious would cope to assure yourself it was real.



Now imagine waking up from this dream. All these experiences, perceptions, emotions, would be gone in the space of a few minutes. You would cling fast to the reality of your dream world, but in the end, it would still be just that- a vivid dream.



humor me. Take it a step farther. Assume you don't have a physical body. Assume for all intents and purposes you are deceased, and the life you are living now is just a reality created by your mind, which is no longer burdened by the task of controlling life functions. It is now free to roam at its leisure and push it's limits. Assuming this is true, other people in your world would be one of two things.

First, they could be the imprints of past people/experiences/lives you have lived or come in contact with. The people would have left enough impression whilst they were living to warrant a spot in your dream world. So when you think about it, even the most insignificant of people in our worlds (both real, or dream, however you are currently perceiving them) has some sort of priceless worth.

Secondly (and personally I entertain this idea) that the dream world we live in is the result of minds leaving physical bodies upon death. No longer bound by the restraints of physical bodies, the minds are left to wander freely and they eventually end up in one collective conscious (the "dream world"). If you have humored me thus far, do so a bit more and assume that the "dream world" is nothing more than a collective conscious- "Afterlife" if you will. Heaven and hell would have no distinction in the dream world simply because the both exist in the same reality. The choice as to what side we stray to would rest solely in the individual (which could be refutable which my earlier mention of a collective conscious). So basically, the "dream world" (IE death) would be indistinguishable from actual life except for the perception of time, which would be irrelevant assuming that the "dream world's" flow of reality was never interrupted (For example, the person waking up/coming out of a coma, etc). If you assume both are one in the same, then you know in your heart that you shape your destiny. Heaven nor Hell is predetermined, but is instead a path the users chooses to walk along.



Maybe I was just rambling. I, Myself, can see the linear progression of ideas here in what I posted, but some of you may not, which would be understandable."
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Well I can definitely see your point there. You're not really treating uncommon existential issues, but I guess some of the experiences you had while seemingly separated from your body made the answers seem a lot further within reach than they really are. I personally would definitely like to believe I've integrated the dissociative experience into my religious views to a limited degree, but that becomes more apparent after use or especially during a period of frequent use.

Still it remains just that, personal issues, experiences, personal answers that count for you alone. Dissociatives tend to give me an impression of what I perceive as objective truths, so I feel like it uncovers what was previously hidden to me. It's dangerous to assume though that these realizations would come to anyone else though by your laying out your theory that really has no foundation in other peoples' reality.

There's a theory about DNA methylations generally being protective for the developement of some mental diseases and I can see how these dissociatives sometimes lift not only our memory on a cellular level as we can see with tolerance, but that maybe this same effect seems to rid us of some sort of behavioural memory that allows for free thinking, overcoming of fears and repetitive negative thought patterns, but also seems to be less beneficial to orientation in social constructs. I've seen people describe long term users of dissociatives as self centered and still can't quite make all connections as to what these substances do, especially with any long term studies on behaviour missing and everyone using these substances usually being on several other psychoactive drugs on a more or less regular basis.
 
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MyDoorsAreOpen said:
2 weeks going strong on 60mg DXM, 200mg Suntheanine, and 2 shots of black espresso to start my day. I am very impressed. I'm a third year medical student on my surgery rotation, which is far and away the most demanding thing I've ever done. I am motivated, can-do, and emotionally stable like never before. I never thought I could muster such calm and such such productivity at once. I don't take anything any asshole doctors say personally, which is something I used to have a real issue with that I couldn't will away.

I am almost certain now I will never touch amphetamine again. This is increased dopamine and serotonin tone the way my body naturally sets it, differentially. Adderall, on the other hand, was turning all the DA neurons in my body up to 11. Why tolerate the shitty comedown and side effects, when I can get enough neurostimulation to improve my life without any side effects!

I also have no taste for alcohol at all on this regimen. I know I will have it socially now and then, but I can honestly say it wouldn't kill me to never have it again.

The only downside I've noticed (especially on my job!) is a MILD memory impairment. But the tolerability of the toil is worth the trade off for sure.

I'm going to try Delsym next week and see if it's better, as a time-released prep with a longer duration, no bromine, and more conversion to DXO.
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Hey mate,

Does this regime still work for you?

Cheers
 
I'm skeptical of the whole thing (stopping tolerance). Tried 60mg delsym years ago daily never noticed a difference. This was years ago and I eventually went off all stimulants/benzo's/meds for 4 years. Those 4 years sucked i became a hermit, stopped listening to music totally (as nothing gave me pleasure). Stopped hanging out with most people (because there was never a feeling of positive reinforcement or pleasure, only negative because of anxiety, couldn't wait to get home by myself and do passive things like watch TV)

Well its just not working out, so i'm back on stims and benzo's. At first, 0.25 klonopin almost fucked me up like I was drunk. Back years ago when i was on the dexedrine (60mg/day)/4mg kpin a day, it worked every day same dose.. took 4mg in the morning every day for 7 years and it always worked.

But now, for some reason, even 8mg kpin in the morning doesn't work as good and i get a lot of sedation (then i counteract that with more stims). And, I have to add 2-4mg xanax every 4 hours or so to keep anxiety at bay. Its strange that years later, xanax is working better than klonopin.. it was the reverse before. Difference is i'm using d-meth oral doses until I get into this free clinic (free psych docs, free meds, even non generics).

So I bought Curcumin, NAC (n-acetyl-cysteine), l-tyrosine, DLPA (on the way in the mail), and some supposedly good quality CoQ10 100mg (doctor's best brand for both the curcumin and CoQ10 with bioperine in both, 3mg in the curcumin and 5mg in each CoQ10).

First capsule of Curcumin I took on a comedown seemed to totally get rid of the urge to redose the stimulant (d-meth) and felt a nice buzz almost. But could be placebo because next few days tried taking 2 caps or 3 throughout the day, i should stick to just one maybe, or one in the A.M. one at night).

Now for the NAC... I took it before the meth early in the day and it almost totally killed it.. dampened it severely (600mg NAC). So I figure its best to take at night (when i would want to kill the effects of the meth). Took 1200mg NAC before bed last night, the meth worked fine in the morning. It just doesn't seem do-able to take any during the day (or maybe split the capsule and take 2-300mg?) because it basically just kills the stim.

Also, i have Pregnenolone which I read can kill just the sedating effects of benzo's without killing the anti-anxiety effects. Nope.... it just kills the benzo including all the desired effects (anti-anxiety), not totally but I was definitely way anxious after taking the preg almost like it justs blocks benzo's. I've read it might work differently taken sublingually but who knows.

Don't notice anything with CoQ10 but didn't expect to. Whats a good dose, 100mg 3 times a day?

L-tyrosine is occasionally good on a stim comedown but i notice it only works (gives me a nice feeling and less of the bad comedown feelings) if I use it sparingly, not every day. Like 1-2g empty stomach. BTW, had a bottle of N-acetyl-L-tyrosine and I think it sucks it does not seem to absorb better or do anything at all no matter how much I took so its probably a sales gimmick..

My sister has PKU (inability of an enzyme to convert phenylalanine into tyrosine properly, leading to dangerously high "phe" levels in the brain) and i could be a carrier (50% chance). I've read somewhere even carriers can *possibly* have very very slight PKU. So i'll see what DLPA does (if anything noticeable at all).
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Oh, one more thing, the reason I quit meds was I went totally psychotic (60mg or more dex a day) but I just wasn't sleeping right. Lately been using seroquel which knocks me out and seems to KILL all stim effects (i get hungry etc and seem to feel the benzo's a lot more if i walk around). I found trazodone to also work well. Hydroxyzine is wonderful stuff too for sleep but its not as good if there's still enough stimulants in your body at night. But as long as i get a solid 6-7-8 hours of good sleep, i never notice a hint of psychosis type stuff ever.


I am curious about memantine but I am just gonna bet that it'll kill the stims effects if anything. Seems like its always a catch-22. All these benzo's in my system halt my sex drive which sucks (only way to get horny is to do a large dose of a stimulant). I can chat with the hottest girls on these drugs and have actual conversations that give me pleasure, but have less of a sex drive :( . I've tried a handful of SSRI's but they make me feel SO SHITTY and twice as anxious, that I can't stand them for more than 2 days to allow them to "kick in" after weeks. I hear close friends of mine saying celexa (one of the worst for me) and prozac are helping their anxiety a lot.. makes me almost want to try again and hope benzo's chill me out enough for it to actually kick in.
 
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Does this work for Oxycontin? & is it the same dose & safe to take with oxycontin?.
 
First off, don't bump your post, and second - this is a thread of anecdotal reports, how about you read it and judge for yourself? I un-approved the other two posts you made in a similar thread. Bluelight is not a real time chat; it's a public forum that sometimes moves very slowly.

There are no "miracle cures" for tolerance, and especially not when you get opiate abuse involved.
 
Psycho lol...I dont have time to read it all & i'm not abusing opiates. I just want to know peoples opinions?
 
Don't expect people to hold your hand - there's 20 pages of experiences you are sitting on that you "don't have time" to read.
 
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