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MDPV - So how dangerous is it?

well im 5'11 and 215lb most Dose/Trip reports i read the people was around 140-185lbs and for years i was drinking lots of energy drinks for many many years! id say my hearts use to the abuse but ill think ill treat every bag deferent just in case. never know whats in this little bag (exp felt as if doing coke even with just a little bit even, smelled like it too)
 
MDPV's Safety Revisited

After reading over and over again, stuff with people talking about using SEVEN GRAMS of PV in a month, or smoking a full gram in a day, etc... I've concluded that at least short term, MDPV is probably the safest dopaminergic stimulant in existence.

It only looks dangerous because people are able to abuse it SO wildly due to its safety, that they run into wacky problems related to their own abuse, not the drug. I'm truly convinced that MDPV is a remarkably safe drug.

Compare 7g of MDPV in a month to cocaine, using standard dosings -- this would be perhaps a couple kilos worth! What would that do to you? :o.
 
BlackStatic69 said:
well im 5'11 and 215lb most Dose/Trip reports i read the people was around 140-185lbs and for years i was drinking lots of energy drinks for many many years! id say my hearts use to the abuse but ill think ill treat every bag deferent just in case. never know whats in this little bag (exp felt as if doing coke even with just a little bit even, smelled like it too)
Click to expand...

energy drinks do not really raise your tolerance to dopaminercigs such as mdpv. if you would have ingested 0.2g of mdpv with no tolerance you would most likely be in psychosis. some people sell mdpv in very diluted form or replace it with another chemical thats cheaper

and id have to agree that mdpv seems very bening if used in moderation. the problems start when you use large ammounts every day
 
After using MDPV regularly for about a month, I'm starting to realize it's very different from other stimulants I've tried in a lot of ways...some of which make me question its toxicity. Maybe some of you can relate?

Tolerance: While other stims simply become less effective as tolerance grows, MDPV seems to cause actual fatigue/drowsiness the more I use it. I can now fall asleep within an hour of dosing. In fact, this is the first time in several years I've been able to sleep through the night without valerian or another sleep aid.

Cognition/Focus: Increased mental focus is a hallmark of most stimulants, but many MDPV users report feeling "scattered", "foggy" or unable to focus on the drug. After a few doses (5-10 mg. total), I find myself staring blankly at things, stumbling to find the right words and forgetting what I was doing 2 minutes ago.

Body Temperature: Both classical stimulants and empathogens can raise body temperature. For me, MDPV increases body temp far more than stimulants or even high-quality MDMA, causing what feels like a full-on fever. This is not due to physical activity, as I rarely do anything other than sit or lie down while high. My typical response to stimulants is actually the opposite: feeling cold all over, especially in the hands and feet.

Heart/Breathing: Other stims make breathing easier while speeding heart rate a bit, but again MDPV is a glaring exception. About 20-30 minutes after a dosing, I experience what feels like an asthma or panic attack that is not anxiety-induced. My heart beats extremely hard (visible through clothes) without beating any faster. I've heard many similar reports.

Can any of you smart ADD-ers offer theories on these observations? Mind you, I've taken many "dirty" stimulants before (ephedra + caffeine, Benzedrex, etc.) and never felt anything remotely similar. MDPV seems to go against the typical stimulant profile in almost every way despite claims that it acts on dopamine and norepinephrine like so many other stims. I would assume my supply was another chemical altogether if not for so many similar reports.

*Additional info: My MDPV is a fluffy white powder that's said to be 99.8% pure. It is not an unlabeled "bath salt". I've only taken it orally and intranasally in doses of 2-5 mg.
 
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^ i feel exactly the same effects

maybe it has a serotonergic component or activates some other receptors, trace amine receptors perhaps that produce a cascade effect? or just simply a contaminant

i cant find any studies to back any of that tho
 
Well said Ms. Codone. From my personal trials i find MDPV to effectively zero clinical efficacy as an ADHD medication. The inhibition of 5-HT comes out at higher doses and when used regularly causes an odd sort of toxic psychosis not seen with DNRIs like d-methylphenidate. This compound IS serotonergic, the degree of which is unknown. Bottom line, neurotoxicity aside, the bigger risk is doing something dangerous while under this compounds influence. Few stimulants have made me unsafe to drive; MDPV is one of those.
 
Dedbeet said:
After reading over and over again, stuff with people talking about using SEVEN GRAMS of PV in a month, or smoking a full gram in a day, etc... I've concluded that at least short term, MDPV is probably the safest dopaminergic stimulant in existence.

It only looks dangerous because people are able to abuse it SO wildly due to its safety, that they run into wacky problems related to their own abuse, not the drug. I'm truly convinced that MDPV is a remarkably safe drug.

Compare 7g of MDPV in a month to cocaine, using standard dosings -- this would be perhaps a couple kilos worth! What would that do to you? :o.
Click to expand...

Do you have some sort of proof that MDPV is "safer" than Cocaine or Amphetamine? (or a remarkably safe drug)
Isn't MDPV one of the so called "research chemicals" ?
(Chemicals that nobody really knows what they do to your body and health in the long term)
 
negrogesic said:
Well said Ms. Codone. From my personal trials i find MDPV to effectively zero clinical efficacy as an ADHD medication. The inhibition of 5-HT comes out at higher doses and when used regularly causes an odd sort of toxic psychosis not seen with DNRIs like d-methylphenidate. This compound IS serotonergic, the degree of which is unknown. Bottom line, neurotoxicity aside, the bigger risk is doing something dangerous while under this compounds influence. Few stimulants have made me unsafe to drive; MDPV is one of those.
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QTF. it makes you so distracted. almost crashed my self into another car :p

DeLee said:
Do you have some sort of proof that MDPV is "safer" than Cocaine or Amphetamine? (or a remarkably safe drug)
Isn't MDPV one of the so called "research chemicals" ?
(Chemicals that nobody really knows what they do to your body and health in the long term)
Click to expand...

mdpv is analog of the compound pyrovalerone which was developed ~1960. theres numerous studies on it so its safe to say mdpv is pretty bening compared to releasers like amphetamine and definetly alot more than cocaine
 
I could never take MDPV because of extreme anxiety but some GBL combined with bumps of ketamine (yes the ketamine was essential too) and possibly valium (wich was still in my system because of it its long half life, i will need to try it with gbl and ket only next time) the paranoia was completely abolished.

If anyone else has anxiety problems with MDPV i would like them to try it with bumps of ket and GBL, it turned in a nice stimulant for me then.
 
negrogesic said:
Well said Ms. Codone. From my personal trials i find MDPV to effectively zero clinical efficacy as an ADHD medication. The inhibition of 5-HT comes out at higher doses and when used regularly causes an odd sort of toxic psychosis not seen with DNRIs like d-methylphenidate. This compound IS serotonergic, the degree of which is unknown. Bottom line, neurotoxicity aside, the bigger risk is doing something dangerous while under this compounds influence. Few stimulants have made me unsafe to drive; MDPV is one of those.
Click to expand...

Certainly most substances which contain methylene-dioxy ring with the structure of Phenethylamine skeleton have somewhat serotonergic property, and it's important that they all releasing agent, not reuptake inhibitor. There're many characteristics of DA:NE:5-HT ratio but this property is common. This means that if the substance is not RA then it could be not serotonergic even has MD ring. MDPV is representative of the substance with this pattern property. According to the article issued from local government office research institution, this is 20-fold more potent NDRI than Cocaine at Ki base, but virtually no effect to 5-HT, and not has any releasing agent activity, might be due to structural of pyrrolidine ring that is too big to penetrate VMAT.
 
Negro are you basing your statements that MDPV is serotonergic on your subjective experiences or do you have some additional info? It feels not remotely serotonergic to me, and I have seen no evidence to support such. But then again I haven't really looked. What do you know?

Cheers
 
Thanks for the feedback peeps!

Seems like MDPV has only bad serotonergic effects--overheating, dysphoric comedown, feeling like an E-tard...all things I've experienced on MDMA, mephedrone and methylone. The difference is those drugs have an element of empathy/euphoria that makes it kind of worth it. The palpitations and shortness of breath I get on PV are totally unique for me though.
 
I get shortness of breath from mdpv too. Even tho I like it to a degree,it does(for me anyway) have more crappy side effects than good effects.
 
Lady Codone said:
Thanks for the feedback peeps!

Seems like MDPV has only bad serotonergic effects--overheating, dysphoric comedown, feeling like an E-tard...all things I've experienced on MDMA, mephedrone and methylone. The difference is those drugs have an element of empathy/euphoria that makes it kind of worth it. The palpitations and shortness of breath I get on PV are totally unique for me though.
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Things like hyperthermia, dysphoria and a feeling of dull emptyness can also be brought about by dopamine, so is in no way indicative of serotonogic action. The feelings of empathy are the key - if they're lacking, it's a good bet they're dopaminergic in origin. Amphetamine can cause all those effects and has negligable 5HT actions
 
^^^ I was hoping you'd chime in here and shine some light on these nether regions! I am not sure where these claims of MDPV being serotonergic are coming from....and stranger yet the effects people are attributing to its supposed action on serotonin are not things I normally equate with 5HT. So what gives? Am I missing something?
 
amanitadine said:
^^^ I was hoping you'd chime in here and shine some light on these nether regions! I am not sure where these claims of MDPV being serotonergic are coming from....and stranger yet the effects people are attributing to its supposed action on serotonin are not things I normally equate with 5HT. So what gives? Am I missing something?
Click to expand...
No -- MDPV is not serotonergic. At all. It doesn't even seem to affect norepinephrine very strongly... it's mainly dopaminergic. Thus its reputation as insanely more-ish, but not particularly enjoyable in the way MDMA or even cocaine is.

What's funny is that I've never gotten palpitations or shortness of breath on MDPV, even on insane amounts of it. Rapid heart rate yes, raised blood pressure yes.

Much of the way a stim affects someone depends on their psyche, and the way they react to anxiety and stimulation. This is especially true with MDPV, which is mainly psychological/mental in its effects and has very little body load. It's conceivable that someone *very* stable and mostly immune to anxiety would hardly feel MDPV's effects.
 
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Dedbeet said:
No -- MDPV is not serotonergic. At all. It doesn't even seem to affect norepinephrine very strongly... it's mainly dopaminergic. Thus its reputation as insanely more-ish, but not particularly enjoyable in the way MDMA or even cocaine is.
Click to expand...

This is simply not true, this have never been formally evaluated as far as I know. No one has posted the data and the data for all similar compounds in the literature specifies these drugs are generally best at being NET inhibitors.
 
FandB said:
Things like hyperthermia, dysphoria and a feeling of dull emptyness can also be brought about by dopamine, so is in no way indicative of serotonogic action. The feelings of empathy are the key - if they're lacking, it's a good bet they're dopaminergic in origin. Amphetamine can cause all those effects and has negligable 5HT actions.
Click to expand...

Is empathy even a good basis for detection thereof? I don't find cocaine or meth very empathetic, despite there ostensibly being functionally relevant serotonergic activity for both. If anything, I think that meth bears the slight mark of an mdma-esque body high....I haven't assayed enough reuptake inhibitors to comment on the serotonergic component of cocaine. If anything, I use ratio of mydriasis to subjective effects as a gauge.

nuke said:
This is simply not true, this have never been formally evaluated as far as I know. No one has posted the data and the data for all similar compounds in the literature specifies these drugs are generally best at being NET inhibitors.
Click to expand...

Negrogesic posted a binding-screen based study of several analogues a couple of pages back in this thread. It suggested that some similar to mdpv might have very slight serotonergic activity, on the order of d-amphetamine's. I would consider this negligible, but Negrogesic argued it relevant at high doses.

ebola
 
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