permatripping? Sounds like some druggie-lingo that someone in the DEA fantasized out of thin air as a PR thing? There is no such thing. Unless you mean the person became mentally ill, and some state of psychosis was triggered. But "permatripping"? That's pretty ridiculous, rather a juvenile expression IMO, no offense, but come on.
... but this has nothing really to do with the topic at hand. i think you can get to that place with any psychedelic, really, as it's more of a psychological thing than a pharmacological thing. The idea that people are "permatripping in a different way than people were permatripping in the 90s" is laughable.
There is definitely such a thing as people who ate too much L and were never quite right in the head afterwards ... I dunno if you could correlate it to anything specifically wrong with them in a clinical sense, but it's definitely something that you can observe if you hang around festivals/raves/etc. Some schizotypal traits, HPPD-ish stuff, general weirdness ...... but this has nothing really to do with the topic at hand. i think you can get to that place with any psychedelic, really, as it's more of a psychological thing than a pharmacological thing. The idea that people are "permatripping in a different way than people were permatripping in the 90s" is laughable.
I've heard that the psychosis may have something to do with the pineal gland being stuck open.
There is definitely such a thing as people who ate too much L and were never quite right in the head afterwards ... I dunno if you could correlate it to anything specifically wrong with them in a clinical sense, but it's definitely something that you can observe if you hang around festivals/raves/etc.
I think it's safe to say, at any rate, most if not 99% of the stuff you find on blotters sold nowadays is not LSD. Real LSD lasts a solid 12 hours and is very anxiogenic. Also, its visuals only occur at relatively high doses and are slow moving. Startling flashes of insight are to be expected.
God no 8( Psychosis caused by the ingestion of 5HT2A-agonist psychedelics is quite well documented and is not believed to involve the pineal gland in any way.
I have read part of this thread before, sorry if I am repeating something said in the other part but how is it that in the very long discussions about clean vs. dirty LSD it is argumented that the explanation has to be placebo, since there are no LSD-like derivatives active in the microgram range... yet here we are talking about such derivatives, even if they are said to be as good as or better than LSD in terms of subjective effects.
Am I wrong to take this as a suggestion that it's not unthinkable at all anymore that there are similar compounds, equally potent, which are much LESS positive in effect?
Apparently Nichols wrote an article about this saying that evidence supports the theory that there are two phases in the effects of LSD, one of which is stopped by 5-HT2A antagonists but the other one is only partially blocked. In that phase though haloperidol suddenly does have effect which acts through antidopaminergic action.
This suggests that D2 dopamine activity could account for at least part of psychotic reactions. I think that compounds that are unlike LSD in this respect might be less prone to cause psychotic reactions although even pure 5-HT2A agonism could most probably drive someone loopy.
Sometimes it is said that mushrooms have a somewhat smaller chance in this respect, perhaps that is because the action of the tryptamine alkaloids lack any dopaminergic component.
Just throwing some ideas aroundI don't mean to steer too much off-topic.

It’s apparently been added to some LSD in order to potentiate the effects of street acid. SWIM has come across LSD with scopolamine or atropine in it. It makes your face a little red and your eyes get super dilated and you feel a little dry. It’s actually quite a nice combination, very visual, more so than pure LSD is. The usual amount added to the acid is said to be about 20 micrograms (according to some old LSD chemists SWIM once chatted with, don’t know if it’s true or not). It doesn’t seem to be a common practice.
Since it's already been resurrected.....why would a pharmacist know ANYTHING about laying compounds onto paper? lol...Miligrams can fit on a blotter, no doubt, i talked to some friends who are pharmacists