RCs The Methiopropamine N-methyl-1-(thiophen-2-yl)propan-2-amine (MPA) Megathread

[abrad84]

I find this a nice stimulant at doses of about 50mg. Doesn't seem too hard on the body and no fiending has been noted as of yet. I also find it pretty easy to eat on. Decent enough stuff but unlikely to take off in a big way imo.

 

[Lazyscience]

what does it mean when people talk about a 'clean' high?

also, do you think it would be difficult to convert methiopropamine into methamphetamine with a little chemistry knowledge?

 

[abrad84]

Clean meaning clearheaded I would think, quite the opposite of mephedrone.

I would suspect a far simpler route to methamphetamine would be by reduction of pseudoephedrine (the usual route in other words).

 

[phatboy303]

"Clean" is a kinda hard word to define. I guess if something doesn't feel like I've injested a toxin then it feels clean.

Nice vodka can be quite clean, whereas cheap lager can feel quite dirty. Caffeine is clean, speed is dirty. I would apply this to both mental and physical effects.

 

[Morpheus19]

Caffeine is clean, speed is dirty. I would apply this to both mental and physical effects.

I would say that caffeine feels way more 'dirty' than speed, in fact, speed feels quite clean, compared to other stimulants.

 

[abrad84]

Speed feels cleaner than caffeine imo. It's all subjective though I suppose, I really dislike caffeine. I would consider mephedrone an excellent example of a "dirty" stimulant.

 

[phatboy303]

Good drone, the sort you don't see much these days feels quite clean to me compared to some of the smellier stuff that used to float around. I can't really talk much about the stuff thats available now as i kept myself a nice stash from the glory days, which has unfortunately just run out.

 

[adder]

Am I reading that wrong? - it seems you don't think it's a bad idea......?

It's only a good idea if one likes to experiment on one's own body.

I'm not sure I like the tone of Adder's post...kinda confrontational.

Methiopropamine certainly feels a lot like amphetamine. The fact that it may or may not be pharmacologically similar is neither hither or thither.

I don't think I've read one report here stating that this drug is definitely a strong stimulant with pronounced central effects. Well, I'm glad if it is but the other thing is safety of using this drug. If you state it feels a lot like amphetamine and it's based on your subjective opinion after using, then alright, I buy it. But still I have no sheet on its safety (not that I really want to try this drug, if I was desperate, I'd do it but after taking mephedrone and flephedrone, I'm skeptical about any drug showing up supposed to be a stimulant or an entactogen).

The other thing is as a chemist-to-be I'd really want to see some affinities, if it does work similar to amphetamine, it blocks DA, NA, and 5-HT uptake by phosphorylating their transporters but what are affinities for each? What is its pharmacokinetic profile? We won't know because this drug just entered RC scene and with seeing mephedrone banned in so many countries and no tests done on it, the same is going to happen to this if it's really such a good stimulant (well, you're supposed to get a lab grade product from a vendor, right? so if people post that 50mg + 50mg cause at most threshold effects, then the effective dose of N-methyl-1-(thiophen-2-yl)propan-2-amine is much higher than amphetamine's, even keeping in mind this is a racemate).

The tone of my post may be kind of confrontational because there are really no confirmed effects of this drug and people carelessly even mix it with other drugs. Well, it's their choice, I don't preach anymore. I'm just shocked... I prefer to know what I take before it turns out my brain is a mash.

Speed feels cleaner than caffeine imo. It's all subjective though I suppose, I really dislike caffeine. I would consider mephedrone an excellent example of a "dirty" stimulant.

It's probably because caffeine's effects are mainly peripheral and amphetamine has a concrete central action (anyway their actions are different so it'd be better to compare ephedrine with amphetamine, I guess). For me amphetamine is a dirty drug as well because of its side effects and you smell like shit after using it too (especially if you use some street speed).

 

[Top Cat]

I ordered a half g of this and a half g of methoxetamine. I'm going to try out the methoxetamine tomorrow and then then mpa on saturday. I was planning on taking some valium and possibily some methoxetamine if I have any left on the saturday when I'm coming down, however I'd like to know if this is potentially dangerous?

 

[Mr Blonde]

^ See some posts in this thread and the thread that is on the front page of OD... the methoxetamine and methiopropamine combo is apparently not such a good idea. There has been a report(s?) of vasoconstriction and high blood pressure.

also, do you think it would be difficult to convert methiopropamine into methamphetamine with a little chemistry knowledge?

Probably very difficult. Even for someone with a lab set-up and access to chemicals, there are probably far more efficient routes then trying to replace the thiophene with a phenyl ring.

 

[Top Cat]

^ See some posts in this thread and the thread that is on the front page of OD... the methoxetamine and methiopropamine combo is apparently not such a good idea. There has been a report(s?) of vasoconstriction and high blood pressure.

Ah okay, noted. Would valium probably be okay? I really hate comedowns and I don't really want to smoke any weed.

 

[Mr Blonde]

Well, keep in mind that this is a very new RC and we don't know much about it.

I'm assuming it's pharmacology is somewhat similar to amphetamines, with some mechanism that is leading to increased vasoconstriction above what an equivalent dose of methamphetamine would do... maybe 5HT2B agonism?

Benzodiazepines should be safe. I don't like cannabis personally so I would avoid it but others may have more insight on that combination.

 

[Top Cat]

Well, keep in mind that this is a very new RC and we don't know much about it.

I'm assuming it's pharmacology is somewhat similar to amphetamines, with some mechanism that is leading to increased vasoconstriction above what an equivalent dose of methamphetamine would do... maybe 5HT2B agonism?

Benzodiazepines should be safe. I don't like cannabis personally so I would avoid it but others may have more insight on that combination.

Okay, thanks for the help

 

[Disco Doctor]

Tried this for the first time tonight, and, perhaps foolishly, combined with a bit of MDAI. Had drank a few drinks before bombing around 150mg of MDAI, 30 mins later snorting 50mg of MPA. To us coke-starved Brits, I found it to be a great, reasonably euphoric stimulant that went well with booze. Better than most of the snip-a-gram repressed shite that is doing the rounds.

Anyway, definitely worth a look. I did a more full trip report type thing here:

http://www.bluelight.ru/vb/showthread.php?p=9216187&posted=1#post9216187

 

[Methox23]

Tried this for the first time tonight, and, perhaps foolishly, combined with a bit of MDAI. Had drank a few drinks before bombing around 150mg of MDAI, 30 mins later snorting 50mg of MPA. To us coke-starved Brits, I found it to be a great, reasonably euphoric stimulant that went well with booze. Better than most of the snip-a-gram repressed shite that is doing the rounds.

Anyway, definitely worth a look. I did a more full trip report type thing here:

http://www.bluelight.ru/vb/showthread.php?p=9216187&posted=1#post9216187

Nice to here a positive report, i ordered a G.... im looking for a clear headed stim, that goes well with booze....plan on drinking sat... Are the effects anything like Speed?

 

[Disco Doctor]

Nice to here a positive report, i ordered a G.... im looking for a clear headed stim, that goes well with booze....plan on drinking sat... Are the effects anything like Speed?

Not as strong I would say. If someone sold you this as coke I think you wouldn't be disappointed. But then again, I only took small doses so I'm not sure what it's like after a decent sized line. But for the price it is going for at the moment it is well worth a shot to see if you like it. I have hardly made a dent in my gram and I'm still buzzing from three lines taken since 9.30pm...

Goes very well with booze though, I found. I can't believe the number of potential situations where I could have acted like a cock tonight and I didn't. Apart from cracking onto a 67-year-old woman, but she was absolutely stunning...8)

 

[Methox23]

Not as strong I would say. If someone sold you this as coke I think you wouldn't be disappointed. But then again, I only took small doses so I'm not sure what it's like after a decent sized line. But for the price it is going for at the moment it is well worth a shot to see if you like it. I have hardly made a dent in my gram and I'm still buzzing from three lines taken since 9.30pm...

Goes very well with booze though, I found. I can't believe the number of potential situations where I could have acted like a cock tonight and I didn't. Apart from cracking onto a 67-year-old woman, but she was absolutely stunning...8)

Cool, I plan on taking it on a night out so dont want anyone to be able to tell to much lol, anyone notice you were buzzin ?/

 

[Disco Doctor]

O to the M to the G. Just lost a bloody big post by being cac-handed...

In a word Methox23, no. I was with a few mates who were totally sober and driving, and they thought I looked fine. It went great with booze for me tonight - doesn't overpower it but gives you that nice alert chattiness. For snip I think it's well worth it. I've hardly made a dent in my gram - probably about 150mg since 9.30pm.

Just hope I can get to sleep alright tonight... I'm still blathering on here with no sign of slowing down...

 

[Domdaniel]

Tried this for first time yesterday and was quite impressed with it, especially at half the price of reasonable quality coke! I'm finding the buzz lasts for about 2 hours and then gently tails off... nowhere near as abrupt as coke. I found it had a good stim effect with a gentle euphoric buzz on the up. My dose was 10mg plugged as an allergy test followed by 50mg plugged an hour later.

 

[adder]

also, do you think it would be difficult to convert methiopropamine into methamphetamine with a little chemistry knowledge?

Aside from this quote:

Probably very difficult. Even for someone with a lab set-up and access to chemicals, there are probably far more efficient routes then trying to replace the thiophene with a phenyl ring.

I'd like to smartly notice that relative yield would be very small compared to other well-known methods starting with well-known semiproducts as substrates.

I'm assuming it's pharmacology is somewhat similar to amphetamines, with some mechanism that is leading to increased vasoconstriction above what an equivalent dose of methamphetamine would do... maybe 5HT2B agonism?

Why this 5-HT receptor if basically a lot of 5-HT receptors cause vasoconstriction?