RCs The Methiopropamine N-methyl-1-(thiophen-2-yl)propan-2-amine (MPA) Megathread

[Albion]

To be honest, trip reports made by people who are still high are pretty funny.

 

[Pythagoras]

How does Methiopropamine compare to amphetamine in desired effects? As i heard its effects are similar, ist the euphoria greater than with amphetamines? The ego boost? Alertness? Concentration? Will recieve my 2g propably today in the afternoon and am very curious about it.

Never having done meth its hard to say. I would put it on good footing with 'nothing to write home about' base dextro - been a while since I've dabbled but my last dealer dealt speed paste in one g blobs (he was too lazy to remove all moisture, but it guaranteed it wasn't cut and smelt very chemical heavy. We used to roll it into long sausage shapes a nibble the night away on it. Methiopropamine is on a par with that - good British speed, but so far without the horrendous comedown..

Not eaten or slept since yesterday but managed an appointment with my drugs worker which I think went well. Mostly snorting 50 mg lines, or bombs, then this evening tried to smoke some - first time and was failing miserably.

Overall not too shabby (its not Meph, or Meth) but a clean speed substitute (depends on how easy sleep comes tonight...and how I feel after a kip)

I'd stock up before they ban it after it appears in cut street speed.

Hope that helps. For me its time for a couple of kpins, then bed...though I have just come across 50mg aMT in my drawer - or would that be tempting the Fates??

 

[DressedInBlack]

Never having done meth its hard to say. I would put it on good footing with 'nothing to write home about' base dextro - been a while since I've dabbled but my last dealer dealt speed paste in one g blobs (he was too lazy to remove all moisture, but it guaranteed it wasn't cut and smelt very chemical heavy. We used to roll it into long sausage shapes a nibble the night away on it. Methiopropamine is on a par with that - good British speed, but so far without the horrendous comedown..

Thank you very much. Had my first try today with 50mg vaporated, am still high and feeling good. Not overwhelwingly good, but very awake, similar to amphetamine as many were pointing out.

 

[Si Dread]

Yeah, it's a very pronounced effect I'm afraid. After about 50mg it is quite hard to piss. You get this from several norepeniphrine re-uptake inhibitors, some of them are actually prescribed for people with urge incontinence e.g. Duloxetine, pseudoephidrine. I actually quite like the feeling. Does this make me kinky?

Yes!

You can ease the effect quite a lot by sitting down to piss. Puts your urethra at a better angle and releases pressure on it. Good for your prostate too, if you do it long term. Just don't try doing it at the urinals in the club. Might be misinterpreted.

Indeed! Lol

 

[captain codshit]

Never having done meth its hard to say. I would put it on good footing with 'nothing to write home about' base dextro - been a while since I've dabbled but my last dealer dealt speed paste in one g blobs (he was too lazy to remove all moisture, but it guaranteed it wasn't cut and smelt very chemical heavy. We used to roll it into long sausage shapes a nibble the night away on it. Methiopropamine is on a par with that - good British speed, but so far without the horrendous comedown..

Not eaten or slept since yesterday but managed an appointment with my drugs worker which I think went well. Mostly snorting 50 mg lines, or bombs, then this evening tried to smoke some - first time and was failing miserably.

Overall not too shabby (its not Meph, or Meth) but a clean speed substitute (depends on how easy sleep comes tonight...and how I feel after a kip)

Sounds nice to me. I've got a sample of this on the way from a legit vendor. Between the comparisons people have given to strong speed & MDPV, yet more euphoric than PV, & less comedown than speed, it sounds a winner to me.

I'll probably start off with a tester allergy sniff then move into chasing. Sounds the best ROA for this one.

It's all interesting stuff anyway!

How toxic do we think this is vs standard racemic amphetamine? And does it have that concentration that can be useful same as amp or pv?

 

[naginnudej]

Sounds nice to me. I've got a sample of this on the way from a legit vendor. Between the comparisons people have given to strong speed & MDPV, yet more euphoric than PV, & less comedown than speed, it sounds a winner to me.

I'll probably start off with a tester allergy sniff then move into chasing. Sounds the best ROA for this one.

It's all interesting stuff anyway!

How toxic do we think this is vs standard racemic amphetamine? And does it have that concentration that can be useful same as amp or pv?

It seems as though cardiotoxicity and vasoconstriction are the real concerns with this one. Toxicity is really dose dependent so you'll have to size up what kind of stim user you are.

If you plan to push recreational dose limits (i.e. users here doing fat doses) then toxicity is most likely higher then the equivalent racemic amp dose. I only assume so because regular methamp's toxicity is higher than amp and this is a closer cousin to methamp than amp from what I understand.

Lower study-aid esque doses (i.e 10-25mg) with sleep, food, etc.. shouldn't be of too much concern but from the sound of your post I think you're looking for a euphoric push so repeated dosing is never advised--especially with a novel compound like this.

 

[Poodles!]

This definitely seems like it might be a good study aid. I've just tried plugged 50 mg, with a 25 mg top up 2 hours later and it gives a good clear headed high.

There's a battle going on between feelings of wellbeing/light euphoria and anxiety though, So I will probably experiment with this further when I get some more Etizolam (perfect for removing anxiety without being too sedating).

Does anyone think this could combine well with MDMA for a more classic E feel? I can easily get uncut (although the synth quality is questionable) MDMA, but I have no Amp sources.

 

[adder]

I'm still wondering how people find it so easy to be sure that N-methyl-1-(thiophen-2-yl)propan-2-amine is definitely pharmacologically similar to amphetamines...

alpha-methylphenethylamines - I guess you can't do something similar with N-methyl-1-(thiophen-2-yl)propan-2-amine... Amthiophetamine doesn't really turn me on.

Really, 1-phenylpropan-2-amine is such a simple compound that a slight change may give a compound with totally different effect on body and here one aromatic ring is substituted with another. This isn't some ajmaline with complicated ring system, it's just one aromatic group with isopropyl group to which a simple amine is attached. Look how different in actions are dopamine and adrenaline.

I'm really curious about this stuff from a scientific point of view as I'm not willing to take it after I ascertained mephedrone and flephedrone are terrible compounds. And now this... I guess it won't push piperazines out from head-/fun-/whatever-shops. Actually piperazine derivatives based products made the situation on the edge when a few people died after consumption of "boosters"/"afterburners" that were sold there and sanitary inspection pronounced they must be closed - so I'm wondering what other shit vendors are ready to bring on to make money on people who can't buy illegal drugs (right now even brain-washing amphetamine is no close to some BZP/TMFPP combos) but are ready to buy even the worst shit on Earth to get high.

Eyes/iris's didn't enlarge.

Your irises don't enlarge after stimulants, this part of eye is called "pupil", pupils dilate or constrict.

Effects - non existent (possibly should have taken a higher dose?) Although, mouth and throat now feel dry and the carpet taste in mouth has blossomed and now feels like I haven't brushes my teeth in weeks - nasty.

I wouldn't say so. You mentioned earlier "mildly fuzzy head", heart beating a little harder than usual, being "more communicative than usual", and bad taste in mouth. Well, some drugs make a person feel unpleasant taste in their mouths after intake of some drugs and this doesn't only apply to oral ROA - I had a strange taste in my mouth at the beginning of levothyroxine treatment if I didn't eat breakfast; after zopiclone a strange metallic-like taste often is reported as a side effect. So taste alteration is definitely an effect even if it's placebo...

Plugged 20mg AMT (read that was the most effective way) and swallowed 50mg of Methioprpamine mixed in water and on empty stomach.

(If you mean α-MT, i.v. injection is the most effective way)

I don't think mixing a realeaser of 5-HT, NA, and DA that is also a non-selective 5-HT receptors agonist and very mild non-selective reversible MAO inhibitior with N-methyl-1-(thiophen-2-yl)propan-2-amine effects of which you don't know anything about is a careless and reckless move in my opinion.

You expect, as many other people, this drug to be similar in effects to amphetamines and you mix it with α-MT - impressive how you put your health and maybe life on risk. You shouldn't have done that. Besides you sought some effects coming straight from N-methyl-1-(thiophen-2-yl)propan-2-amine, right? How would you know something is caused by intake of this compound if you had mixed it with quite a strong psychedelic?

30-40 mins before noteworthy effects came on. Those looking for Meph replacement, this is not it.

Ah, I guess here's the reason why mixing α-MT with N-methyl-1-(thiophen-2-yl)propan-2-amine was a great idea of yours and you saw nothing wrong in doing it. Are you a "meph-head"? (I call this people who took mephedrone not because it gave them effects better than some similar drugs but because of its legality = they just wanted to stay f*cked up).

 

[davem]

"....I don't think mixing a realeaser of 5-HT, NA, and DA that is also a non-selective 5-HT receptors agonist and very mild non-selective reversible MAO inhibitior with N-methyl-1-(thiophen-2-yl)propan-2-amine effects of which you don't know anything about is a careless and reckless move in my opinion....."

Am I reading that wrong? - it seems you don't think it's a bad idea......?

 

[Albion]

I'm not sure I like the tone of Adder's post...kinda confrontational.

Methiopropamine certainly feels a lot like amphetamine. The fact that it may or may not be pharmacologically similar is neither hither or thither.

 

[Lazyscience]

does anyone have an opinion about whether this would be a good drug to enhance creativity?

i need to come up with some songs and music for my band and im wondering if this might help me with that.

 

[pofacedhoe]

I'm not sure I like the tone of Adder's post...kinda confrontational.

Methiopropamine certainly feels a lot like amphetamine. The fact that it may or may not be pharmacologically similar is neither hither or thither.

might seem offensive but all the points made make sense.

we know fuck all about what it does- its all guesses so far

 

[Repulse]

I'm not sure I like the tone of Adder's post...kinda confrontational.[/quote]
Nonetheless, it was on the spot.
Mixing aMT and a chemical closely related to methamphetamine?

Now, I'm rarely the preacher, and I know people do fat doses on here, but: what the f- was he thinking? Might aswell drop acid and smoke nazi crank in my book.

Methiopropamine certainly feels a lot like amphetamine. The fact that it may or may not be pharmacologically similar is neither hither or thither.

Now this is alot more relevant speculation


In other news:
I received my 500mg sample today, and I will do some low-dose testing as the night progresses.

 

[deckmunki]

Have tried some tonight. Pupils huge (typical) resting pulse elevated from 70 to 85ish, bit edgy. Interesting stuff...

 

[ektamine]

I'm not sure I like the tone of Adder's post...kinda confrontational.
Nonetheless, it was on the spot.
Mixing aMT and a chemical closely related to methamphetamine?

Now, I'm rarely the preacher, and I know people do fat doses on here, but: what the f- was he thinking? Might aswell drop acid and smoke nazi crank in my book.

Shit man, you supplying? I'm sure as hell down..

 

[Mr Blonde]

^ Thanks for the heads up, but this site is not for vendor discussion.

I'm still wondering how people find it so easy to be sure that N-methyl-1-(thiophen-2-yl)propan-2-amine is definitely pharmacologically similar to amphetamines...

alpha-methylphenethylamines - I guess you can't do something similar with N-methyl-1-(thiophen-2-yl)propan-2-amine... Amthiophetamine doesn't really turn me on.

Really, 1-phenylpropan-2-amine is such a simple compound that a slight change may give a compound with totally different effect on body and here one aromatic ring is substituted with another. This isn't some ajmaline with complicated ring system, it's just one aromatic group with isopropyl group to which a simple amine is attached. Look how different in actions are dopamine and adrenaline.

I'm really curious about this stuff from a scientific point of view as I'm not willing to take it after I ascertained mephedrone and flephedrone are terrible compounds. And now this... I guess it won't push piperazines out from head-/fun-/whatever-shops. Actually piperazine derivatives based products made the situation on the edge when a few people died after consumption of "boosters"/"afterburners" that were sold there and sanitary inspection pronounced they must be closed - so I'm wondering what other shit vendors are ready to bring on to make money on people who can't buy illegal drugs (right now even brain-washing amphetamine is no close to some BZP/TMFPP combos) but are ready to buy even the worst shit on Earth to get high.

I'm interested in the pharmacology of this compound as well. I can see why people make the assumption about amphetamine like effects; it is basically methamphetamine with a thiophene substituted for the phenyl ring. So far it's effects don't seem that spectacular... perhaps with this change of structure it doesn't fit so well into the dopamine transporter protein?

You are right about people needing to be careful with this. I will try and find the study I looked at which talked about thio substitutions on the phenyl ring of amphetamines lending them MAOI properties. This compound is potentially an MAOI of some sort; possibly a mild, reversible one but this could still lead to drug-drug interactions which may be unpleasant or harmful.

I understand where you are coming from with your analogy of dopamine and adrenaline. However, compared to those two compounds, the substitution of a thiophene is a drastic difference. Methamphetamine, mephedrone; those compounds share a phenyl ring in common with the monoamine neurotransmitters of the brain. A thiophene's smaller ring and the presence of the sulfur atom probably mean it doesn't affect the transporter proteins as efficiently as the phenethylamines do.

From a patent I am looking at regarding halogenated thiophene-2-isopropylamines used in brain scans, it appears as though the Blood-Brain-Barrier is not so much an issue.

 

[deckmunki]

(This is a pea-roast from here: http://www.bluelight.ru/vb/showpost.php?p=9212541&postcount=58)

(Also, stupid alert: yes, I am stupid. Don't try this at home kids. No, seriously...)

I had a bit of a scare tonight on MXE and Methiopropamine; seemed they potentiated each other into a particularly horrible, 3-hour panic attack which came and went, with a couple of acute tachycardic episodes where my pulse went from resting to ~180 in the space of 20 seconds, at which point I got up and walked as calmly as I could round the room.

Pulse returned to normal but BP and HR are most definitely significantly elevated when MXE and Methiopropamine are present in "normal" doses (approx 35mg and 50mg respectively).

Very worrying stuff; now I'm considering whether I should avoid MXE on any other stimulant drug at all, as previous tests with the Methiopropamine haven't engendered these symptoms, although some tachycardia and vasoconstriction seem inevitable.

/D

 

[Shambles]

Hey Shammy you haven't given the needle a go yet, have you?

Nup. Was all outta 1ml pins and didn't quite fancy the IM option at the time. Was on 400mg of tramadol daily and skipped that for 24hours before sampling me sample of this stuff given the possible MAOi concerns so didn't feel the need to push it too far at the time. Having said that, felt totally safe throughout the day or so dosing via other ROA despite the acute tram w/d. Kinda surprised at how safe it felt, to be honest. Really shoulda been way worse if it were straight phet (methamp would be suicidal under similar circumstance?) but felt fine the whole time. Next batch it'll be needle time methinks

Play safe, kiddiez

 

[ungelesene_bettlek]

is there anything known regarding the pharmacology of methiopropamine? my educated guess would be it is a dopamine/noradrenaline/serotonine releaser, but I guess you just never know for sure.

 

[phatboy303]

Anyone want to read my fairly comprehensive trip report from last night, its here:

http://www.bluelight.ru/vb/showthread.php?t=548952

General jist is I'd describe it as a cross between mephedrone and speed, with good and bad elements from both.