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Bupe Suboxone/Buprenorphine FAQ & Megathread v2; 2010

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You know they have Buprenex for pain, have you considered going on Buprenex for pain before? Do you think the sublingual ROA works better since it lasts a long time?

I do agree that buprenorphine has different "effects" at certain dosages. It gets more sedating at a higher dose and tends to be more stimulating at a lower one in my experience.

:) Hey mate, sublingual is by far the best ROA. This stuff has a mean half life of 37 hours or something, so it really builds up in your system and creates amazingly stable blood levels with just once a day dosing, some people even dose this stuff(strictly for opioid maintainence) every second or third day and it holds them.

I found this stuff to hold me perfectly physically, but it wasn't for me and didn't change my cravings, i find methadone much better. ( got on bmt then mmt for opioid addiction, pain relief is a bonus side effect of my treatment because my neck is chronically fucked)

But for people who strictly need pain relief, someone with no tolerance, bupe could be a wonder drug to them, if they could dose 200ug or whatever and feel great pain relief minus sedation and histamine issues, and it's something you can just dose once a day and you have all round coverage, thats a great thing for alot of people.

Maybe i'm wrong but i don't see bupe being used much for chronic pain patients in Australia and i think it has potential to benefit alot of people.

I think it could be of great value to some people. The only issue is using a full agonist for breakthrough pain, that might be bupes only weakness as a painkiller.
 
I think it could be of great value to some people. The only issue is using a full agonist for breakthrough pain, that might be bupes only weakness as a painkiller.

You can use full agonists after buprenorphine, and with small doses of buprenorphine it does work really well.

I think using buprenorphine primarily help keep your tolerance low.

Great thoughts though, I also think buprenorphine is a great analgesic tool and that it should be prescribed more to pain patients, at least for those people who are willing to try it (if people are happy and stable on full agonist opiates, they should be allowed to stay on them).
 
i dunno why but for some reason i cant find or figure out why precipitated withdrawal occurs which has been buggin me! Can someone help me out with this somewhat obvious answer that i cant find haha
 
I'm not the only one interested in your allegations. Based on my contact with several others here... there's considerable interest in the plausibility of your assertions. These type of questions/responses are important to your credibility. There have been some inconsistancies in your past claims and experiences which have been pointed out to you by several other Bl'ers.

This is mainly because you claim to be on BMT yet have no [acute or Paws]WD's when you quit using... which is apparently quite often. This goes against most everyone elses experience. Now you contend that you supply subs to a couple of heroin addict buddies and they too are absent WD's when they don't use. That makes no sense to most BL'ers who are addicts and on BMT.

Everyone here is essentially anonymous [and must be taken on their word] so when someone volunteers ongoing advice to practically every "newbie" who comes into "other Drugs", they should have no problem to opening themselves up to public scrutiny. This is an open discussion forum and my God man... you've been here about 3 1/2mos and have nearly 2000 posts. Someone dishing out that much advice should be fine with someone asking a fair question related to a previous posting. Why would you publicly post information and not expect to be held accountable for same?
Also... everyone knows most subs dr's test for both use and non use of subs yet you profess to be off subs 3+ weeks while at the same time on BMT. That too is highly suspect. Does your dr continue to subscribe to anyone else who doesn't use their meds? Or is that just a privilige exteneded to you? Come on now... if you want to be taken seriously, then give some open answers to valid questions.

Because the questions you are asking have nothing to do with helping you, or other people. You are merely asking them for your self interest and that clogs up our forums with uneeded information..
Asking me why I keep giving my friends suboxone even though they are like me and arent addicted to it and can stop anytime.....asking various questions about my personal drug tests.....asking very personal questions about my probation(s) and how my PO will respond to what....etc...

....all of that shit^^^^ is uneccessary, but I would be glad to answer it for you if you PM me. I dont know why you have a hard time understanding that. You are welcome to post my PM's to you on the open forums if you like, thats your decision once I give you the information. But like I said, im not going to contribute unrelated personal information to these open forums if its not helping anyone, and by the way you are posting, you seem to have an attitude....whether or not you do, i dont know, but I do know thats the way your posts come across so I am less likely to have patience with someone who treats someone else with direspect....disrespect as in not sending me a PM to ask me personal questions even after I have asked you politely 3 times to do so.

*and just so you will shut up about this whole suboxone dr drug testing me issue....I dont know why you cant remember this but I told you a couple days ago when you asked me this EXACT same question that I can easily stop going to my sub doctor if need be. because of my extremely low dose of sub I was on, i have managed to save up more than enough suboxone to last me quite a long time(but im not even taking it now anyway). Therefore, if I decide to keep going with my sub abstinence when i go to my sub doctor, I can just tell him im leaving the program for whatever reason I come up with and not go there anymore....meaning I dont need to worry about passing or failing a drug test. Did you get it this time?
Does your dr continue to subscribe to anyone else who doesn't use their meds? Or is that just a privilige exteneded to you? Come on now... if you want to be taken seriously, then give some open answers to valid questions

theres^^ the attitude im talking about(disrespect). and they may be valid questions, but like I said earlier, they are not being asked to help anyone.....whether or not my sub doctor cares if i test positive or negative for bupe doesnt help anyone, nor is it up to you to decide if it is your(or anyone elses) business. So, for the last time, PM me with all the questions you like.

*I am no longer going to be responding to your posts as I do not want to get infracted for leading this thread off track.*
 
i dunno why but for some reason i cant find or figure out why precipitated withdrawal occurs which has been buggin me! Can someone help me out with this somewhat obvious answer that i cant find haha

Buprenorphine has a greater binding affinity than full agonist opiates, so it displaces them.

This is similar as to how naloxone will displace (common, i.e. heroin) full agonist opiates in the case of an overdose, because naloxone has a greater binding affinity than heroin.

*I am no longer going to be responding to your posts as I do not want to get infracted for leading this thread off track.*

I don't think you are getting off track, but I do respect your decision to take it to private messages.

I don't think SubDude is trying to be disrespectful though, JB, I think he's just a little in disbelief that you are only taking Suboxone 1 week out of the month and your doctor is still prescribing them to you.
 
Buprenorphine has a greater binding affinity than full agonist opiates, so it displaces them.

This is similar as to how naloxone will displace (common, i.e. heroin) full agonist opiates in the case of an overdose, because naloxone has a greater binding affinity than heroin.

Ive always wondered Captain....do you know of any full agonist opiate that has a stronger binding affinity than bupe at the same receptor sites?
 
Ive always wondered Captain....do you know of any full agonist opiate that has a stronger binding affinity than bupe at the same receptor sites?

I actually have no idea. I know that there are full agonist opiates with a stronger binding affinity than naloxone, so it might be close to, or higher than buprenorphine but I am not sure.

It would be very interesting to find out what opiate agonist/partial agonist has the highest binding affinity (compared to all known drugs with known binding affinities).
 
I don't think SubDude is trying to be disrespectful though, JB, I think he's just a little in disbelief that you are only taking Suboxone 1 week out of the month and your doctor is still prescribing them to you.

Who said I was only taking suboxone one week out of the month?

Oh.....you mean how ive been off of suboxone for almost a month....yea, i have an appointment with him in couple/few days and im not sure if im gonna go or not. but in the past, before I started my "extra long" break from subs, I would always make sure that I had bupe in my system for when I had my sub dr visit. That is why I have had no issues in staying in the prgram. But like I explained, jsut ike you Captain, I am on such a low dose that I was able to save up a shitload of subs, enough for me to be covered for quite a while. So i dont really need the sub doctor anymore, and I could always go back to the same clinic sometime in the future if I want to get back in the program if I quit it. But, if they wont take me(which I doubt would happen), I can go to one of the MANY MANY other dr's that prescribe suboxone in the city I live in. I think its like the 8th largest city in the U.S. Plenty of doctors, thats for sure.

And he can be in all the disbelief he wants, but I would appreciate it if he could show some respect, whether or not he believes my experiences that I talk about on BL. For example, him ignoring me repeatedly about PM'ing me about my personal issues. He may not be trying to be disrespectful but he's still doing it.
 
Who said I was only taking suboxone one week out of the month?
Maybe I mis-read something, I was browsing through posts and saw something along the line to that effect.

BTW - I am thinking that by the time I run out of Suboxone, I will be able to have moved to a different city, and get in with another Suboxone doctor.

I really don't want to go to the one here anymore, even though I had a good thing going (no drug tests, 5 minutes in and out, etc).

My overall goal is to be off of Suboxone within a few years, because as much as I like it, I would prefer to have no tolerance whatsoever. I'm not sure, but I am thinking without using buprenorphine often, a 26mcg shot would be extra-euphoric than what it does for me now. Maybe I'm wrong? It'd be interesting to find out.
 
Im pretty sure that if you stopped taking your suboxone, a 26mcg shot would be extra euphoric. Every time I took one of my breaks from taking suboxone(especially the breaks longer than 5 days), when I re-dosed again, it always felt way more euphoric than it did on average.
 
Does buprenorphine also out-compete naltexone? I do not know if naltrexone or not has a higher binding affinity then nalxone, but if they are about equal then I have another question:

Can bupe also block your endorphins as is the case with naltrexone? If bupe has a higher binding affinity than that of naltrexone, would it not also block your endorphins as naltrexone does? I ask this because the whole time I was on bupe I was very depressed, and I feel much better off it.
 
Does buprenorphine also out-compete naltexone? I do not know if naltrexone or not has a higher binding affinity then nalxone, but if they are about equal then I have another question:

Can bupe also block your endorphins as is the case with naltrexone? If bupe has a higher binding affinity than that of naltrexone, would it not also block your endorphins as naltrexone does? I ask this because the whole time I was on bupe I was very depressed, and I feel much better off it.

The reason why naloxone and naltrexone "block endorphins" is because they are antagonists. Buprenorphine is a partial agonist with both agonist and antagonist properties. This means that it can "get you high" so to speak through its agonist's effects, but it also can block other opiate-receptor-filling chemicals from filling those receptors which might be more agonistic.
 
Does buprenorphine also out-compete naltexone? I do not know if naltrexone or not has a higher binding affinity then nalxone, but if they are about equal then I have another question:

Can bupe also block your endorphins as is the case with naltrexone? If bupe has a higher binding affinity than that of naltrexone, would it not also block your endorphins as naltrexone does? I ask this because the whole time I was on bupe I was very depressed, and I feel much better off it.

I am not sure if buprenorphine out-competes naltrexone.

Buprenorphine probably can block your endorphins. I think this would only happen in cases of high doses (12 to 16mg per day or higher). Your endorphins should work fine at lower doses of buprenorphine.
 
I am not sure if buprenorphine out-competes naltrexone.

Buprenorphine probably can block your endorphins. I think this would only happen in cases of high doses (12 to 16mg per day or higher). Your endorphins should work fine at lower doses of buprenorphine.

^ yea thats what I was thinking, that higher doses of bupe might block it out, such as normally prescribed doses (which are ridiculously high), but at doses like 2-6mg it might not be the case.
 
Also....high doses of buprenorphine tend to make people more groggy and sedated, as well as give headaches and have other negative "antagonistic" side effects(which might make you feel depressed)....as compared to low dose bupe with seems to have none to little of those effects.(unless you are completely opiate intolerant).
 
Technically speaking arnt endorphins and opiate agonists the same thing :)

Anyway CH I saw a post of yours explaining the number of shots from a pill, and it was like 200 or something, you'll probably die of old age before you run out
 
Anyway CH I saw a post of yours explaining the number of shots from a pill, and it was like 200 or something, you'll probably die of old age before you run out

Thats the beauty of low dose suboxone :)....or atleast one of the beauties.
 
Technically speaking arnt endorphins and opiate agonists the same thing :)
Endorphins are endogenous opioid peptides, whereas what we are referring to as full agonists are exogenous opiates/opioids.

Anyway CH I saw a post of yours explaining the number of shots from a pill, and it was like 200 or something, you'll probably die of old age before you run out

LOL, yeah, I am currently getting 300 shots out of an 8mg pill.

I'll say roughly 300 shots. I dissolve one 8mg tablet into 30ml of bacteriostatic water. I believe that the tablet expands in the water, and even after micron filtering, the amount of liquid in the vial is slightly over 30ml. I have no way to accurately measure the difference if there is any. I also probably lose ~0.5 to 1 unit of substance every time I am getting solution out for a shot (since I am putting it out on a spoon and drawing it into an insulin syringe needle - if I had luer lock needles and syringes, there wouldn't be any loss, you can just draw directly out of the vial, and then attach another, new luer lock needle).
 
Endorphins are endogenous opioid peptides, whereas what we are referring to as full agonists are exogenous opiates/opioids.



LOL, yeah, I am currently getting 300 shots out of an 8mg pill.

Psh symantics, I'll simplify
Endorphins = Pleasure
Opiates = Pleasure
therefore
Endorphins=Opiates%)
 
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