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Honokiol & Mulungu extract

Jabberwocky

Jabberwocky

Frumious Bandersnatch
Joined
Nov 3, 1999
Messages
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Looking-Glass Land
wiki said:
Honokiol (C18H18O2) is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. While early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.
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i've just been discussing this with a friend of mine. there's only one thread i could find in OD about it with only one anecdotal report; apparently it is very similar to that of a light benzo dose. Mulungu is also available which is the alkaloid extract which may or may not be better. research shows Mulungu contains at least 20 isoquinoline alkaloids, many of which are anti-inflammatory, sedative, and analgesic in nature. animal studies also suggest GABA and Nicotinic receptor activity.

has anyone heard of this or perhaps tried it out? any input? i can't find anything conclusive as to whether it is physically addictive or not either.


sufficient credible research now exists demonstrating honokiol is a potent and powerful drug, at the right dosage. Oral bioavailability combined with very little toxicity makes for an intriguing drug candidate. However, just because it comes from a “natural” source does not guarantee it is safe at all dosages and over a long period of time.
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http://clltopics.org/Phyto/honokiol.htm

i'm going to go bury my head into more of this and see what i can come up with.
 
I almost picked up some of this today, it sounds intresting. Anyone else got feedback?
 
Haven't heard about this before, but would be very interested in finding out more.

Sounds like it could be very useful for benzo addicts trying to taper or just people looking for some anxiety relief.

The only thing that let me quit benzos last time I was dependant >1yr ago now, was alcohol and weed. Been using valium again for nearly a month now so this would be of great help, I don't want to return to where I was previously with benzos.
 
static_mind said:
I almost picked up some of this today, it sounds intresting. Anyone else got feedback?
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i haven't properly checked out that other forum but do you know if there is mention of it there?

puckboy said:
Sounds like it could be very useful for benzo addicts trying to taper or just people looking for some anxiety relief.
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anxiety relief for me thanks.

i've got high BP(hypertension, yesterday it was 135/100 8o), have had it for a while on and off for 18 months, possibly longer and am only just starting to get pro-active in sorting it out. as a result anxiety is a huge side-effect. i'm at a point where its triggering panic attacks again, so it's getting pretty serious and i've started seeing a naturopath who's given me Proxan* figured to try and go a more natural way reducing my BP rather than straight jumping into another bottle of pills to rely on. but i digress.

*Proxan is a 5htp capsule which includes this
100mg 5-Hydroxy-tryptophan
100mg S-adenosyl methionine
100mg dl-Phenylalanine
50mg potassium phosphate (monobasic)

phenibut is something else that was brought up to me a while ago which i should be able to report on soon.
 
leftwing, to avoid the subject being fragmented, it's worth also posting that info in the hypertension thread, where you can update us with your progress.
 
^you're right PD, i had gone off on a huge tangent and had deleted it all. i was getting around to posting that in the hypertension thread

http://herbalmedicine.suite101.com/article.cfm/honokiol

with a little further reading it's shown through that the Honokiol rather than attaching to GABA, regulates it. the anxiolytic effects alike to that of diazepam(valium) or clonazepam(klonopin) and no sedation brought upon from the effects with no addictive properties. saying that's it's pretty safe to assume there's not going to be any recreational value to it - which isn't what i'm after anyway. if i want sedation i'll take benzos/muscle relaxants.

liposomil honokiol inhibits VEGF-D induced lymphangiogenesis and metastasis in xenograft tumor model

Honokiol Induces Calpain-Mediated Glucose-Regulated Protein-94 Cleavage and Apoptosis in Human Gastric Cancer Cells and Reduces Tumor Growth

i'm still yet to find any first hand experiences of it.
 
static_mind said:
I almost picked up some of this today, it sounds intresting. Anyone else got feedback?
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i signed up to that site you PM'd me but am still waiting for posting access. there is one thread i found but with very little info, nothing new to me anyway. there may be something there worth copying over to here actually come to think of it, so i'll go double check.
 
Pretty common tree in Horticulture in Australia, well... at least the new dwarf variety called 'Little Gem'

It's a nice tree, massive flowers that have a lemon perfume :)
 
Klue said:
Pretty common tree in Horticulture in Australia, well... at least the new dwarf variety called 'Little Gem'

It's a nice tree, massive flowers that have a lemon perfume :)
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reckon you could hit me up with a pm with some data on it brother, klue? you know your buso when it comes to these types of things. anything would be muchly appreciated.

you still owe me a pm:p;)
 
lol oh shit sorry man, i had you mixed up with bit_pattern. sorry dude=D

well yeah, you got that forum to check out anyway

be sure to update in here when you have a chance to use it too, please - the honokiol that is.

is it the mulungu extract or the honokiol you've got coming?
 
I was looking at the Mulungu powder. I couldn't remember what the other one was called when I was hunting around. Il have a look next time as well and see if I can test them both out.
 
I found some Mulungu powder today. They seemed a little hesitant to sell it too me but I got it none the less.

I seeped 1tea spoon worth and filtered with a coffee filter. The tea wasn't too bad, reminds me of bland noodle flavor really.

I sat down with a beer and chilled. I noticed some effects and a slight sedation but when I moved to get another beer was where I noticed my balance was off. Although id only had 1 beer and im a very seasoned drinker I felt impaired enough to be weary of driving.

Only a light dose, thought I might test the waters first. Il try more later sometime.
 
static_mind said:
I found some Mulungu powder today. They seemed a little hesitant to sell it too me but I got it none the less.

I seeped 1tea spoon worth and filtered with a coffee filter. The tea wasn't too bad, reminds me of bland noodle flavor really.

I sat down with a beer and chilled. I noticed some effects and a slight sedation but when I moved to get another beer was where I noticed my balance was off. Although id only had 1 beer and im a very seasoned drinker I felt impaired enough to be weary of driving.

Only a light dose, thought I might test the waters first. Il try more later sometime.
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much appreciated man. give us an update when taken by itself.

i've read of dosages with just the honokiol being at the 500mg. what size do you esimate the teaspoon you used? might be worth weighing out for accuracy:) i'm not too much of a drinker tbh.
 
Il try and get my scales back from a mate soon and il try encapsulating some measured dose's.
 
Any further info on this? Im very interested!

Its a shame that there doesnt seem to be a local supplier of Mulungu extract.
AQIS seems to be cracking down on imported plant materials and i suspect any packages inspected will be detained
 
^there are alkaloidal extracts available, would that be enough to warrant it suspicious enough? i'm not too learned in the AQIS guidelinies

static, any update as yet?
 
I retrieved my milligram scales but havn't yet tried another dose. Iv been a little sus on encapsulating the powder for hygiene concerns, however a tea with boiling water sounds quite sterile. Il try and do 3 grams via tea during the upcoming week. Any perticular effects youd like me to try and pay attention too?
 
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