MyExcuse
Bluelighter
good advice, quoted and bolded for posterity.It does, so please start off ridiculously low so that you may gauge the inhibitor-derived potentiation...
Most NMDA receptor antagonists are metabolized in the liver. Frequent administration of most NMDA receptor antagonists can lead to tolerance, whereby the liver will more quickly eliminate NMDA receptor antagonists from the bloodstream.
from wikipedia
Now I'm sure there are more mechanisms within the body responsible for NMDAR antagonist tolerance, however this would mean that if one has a tolerance and uses a inhibitor, they could possibly avoid the effects of the tolerance.
In fact, now that I think of it, this would explain why the effects changed when I built up a tolerance in the past. Less psychological effects, more analgesia and physical effects (indicative of norketamine). hmm...
Just to mention, this is important for K users for a major reason. If you build a tolerance, your body has to deal with more ketamine, and more ketamine means more damage to the urinary tract and bladder. I believe the reason chronic abusers of K get UT/bladder damage is primarily due to the large amounts they have to consume due to tolerance. This then leads to the body having to deal with processing all of it which can't be good for the liver or the bladder!