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Codeine Extraction

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JimiHawK* said:
the other pills you take shouldnt matter unless they are CYP-2D6 inhibitors (google them) in which case you'll barely feel the codeine (CYP-3A4 inhibitors on the otherhand are reported to increase codeines effects, tho ive had mixed results using grapefruit juice)
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GFJ also inhibits CYP2D6 to some extent if I remember correctly. However I used both GFJ and Zoloft (both CYP2D6 inhibitors) with codeine once upon a time and didn't notice that much decrease in potency. But at the same time, I've always been able to go way over the ceiling dose with codeine and get extremely buzzed off 300-400mg without a tolerance.

belarki said:
One or two standard drinks doesn't hurt either (I'll let mr blonde explain the enzyme effect it has).
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Oh yes, allow me. ;)

Alcohol is a CYP2D6 inducer, which was recommended to me a while back on this forum by another user who I can't remember now... they recommended a glass of wine or a beer about 45 minutes or so before dosing codeine. CYP2D6 is what converts codeine to morphine, so having more CYP2D6 working on your codeine is a good thing. ;)

Of course, don't get drunk and then dose your codeine, the combo is very unpleasant IME. And if your drunk there are dangers of CNS depression when adding in any other downer.

belarki said:
With the chemists own pain tabs, if you're new to codeine then a 24 pack, leaving room for 20% loss during extraction, should be a good dose. As discussed various times throughout the thread any more than ~400mg for most people is a waste and the histamine reaction will be unpleasant enough to wreck the experience.
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Yes, 240mg should be fine for a first timer, my first time with codeine was 12 N+ which made me slightly relaxed and happy. As belarki notes, going above 400mg for most people (not me) is both useless and also will give you the histamine reaction from hell. The LD50 (dose of codeine that will kill 50% of the people who take it) is estimated to be 700mg, and the thing that would most likely kill you would be the overt histamine release.
 
~400mg with no anti histamine made me feel like I was dying, I went bright red, difficulty breathing, painful itch under my skin all over my body, was so desperate to stop it I crushed up about 5 random allergy tablets I found and snorted them, helped a bit but I think you really need to take them before hand for them to be effective.

I was violently ill for about 2 hours after doing this (vommiting, headache and terrible seedy hungover feeling), I tried again with 12mg promethazine and experienced no more than a mild itch as a side effect so anti histamines are highly recommended if you are going to test the waters with higher doses.
 
another question, can you make this stuff in bulk and store the liquid it in the fridge without losing its potency?
 
Romie1092 said:
another question, can you make this stuff in bulk and store the liquid it in the fridge without losing its potency?
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I wouldn't bother. I couldn't see any possible loss of potency however you might find the codeine & ibuprofen/paracetamol/binders settling out of the solution. The concern would be bacteria / fungi cropping up and having a party in that water if it's stored for too long :!
 
woops totally forgot about mold/algea with old water. 8o

Got a 96 pack of chemist own and didnt even need ID :)

So basically with doing the CWE, I crush 24 tabs, put it in around 60ml of warm water. Stir/let it disolve, cool it in the fridge to 10 degrees then filter it out with coffee filter paper, mix with cordial, skull and enjoy?

So ill be trying this tomorrow after work. I will most likely be having it around 4pm. Will I be ok to go out drinking with my mates after 10pm?

Thanks in advance :)
 
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Romie1092 said:
So ill be trying this tomorrow after work. I will most likely be having it around 4pm. Will I be ok to go out drinking with my mates after 10pm?
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Depends how much you are going to drink. If you drink too much you are likely to feel very nauseous and have an unpleasant time, but I find a beer or two on the tail end of a codeine experience can go nicely.
 
Maybe ill save the codeine for another time if im gonna go out later in the night. When I go out drinking its normally 20+ drinks
 
how much is expected to be lost doing a fairly sound extraction. i filtered twice with pre soaked iced coffee filters and was very particular. i have let it evaporate and got the powder of which in theory should be around 400mg. (i am sure this has already been answered and off topic but) . for someone with close to no tolerance is 200mg still a good place?

not really that interested in trying codiene to many side effects. i will treat it as if there is 400mg to be safe but i assuming there is more like 350mg if i am lucky
 
face__ said:
how much is expected to be lost doing a fairly sound extraction. i filtered twice with pre soaked iced coffee filters and was very particular. i have let it evaporate and got the powder of which in theory should be around 400mg. (i am sure this has already been answered and off topic but) . for someone with close to no tolerance is 200mg still a good place?

not really that interested in trying codiene to many side effects. i will treat it as if there is 400mg to be safe but i assuming there is more like 350mg if i am lucky
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If you've had codeine at least once in the past and know you're not allergic to it (hey you never know, could happen?), yet have no tolerance then halving what you have should be a good safe dose. It will at least give you an indicator of how much of a histamine reaction you'll have.

You can always increase the dose next time if desired.

I'm assuming you're taking it orally right?
 
^ Codeine inhibits the enzymes that metabolize MDMA I believe, so I have heard that combo contraindicated on BL... but codeine on the comedown should be fine.
 
yeah cheers and yes will be orally. well i took about 100mg before felt next to nothing as well as no bad reactions. as for antihesamine i have dexchlorpheniramine 2mg's. i usually avoid mixing any drugs at all costs but if the itching is that bad would these be suitable?
 
fantastic. so a single standard drink, grapefruit juice and say 4mg dexchlorpheniramine and approx 200mg of codiene. well this should be interesting i will let you know how it goes
 
Romie1092 said:
bad idea to mix eccies after codeine high?
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codeine with MDMA is amazing, one of the best highs I've ever felt. Even much better than oxycodone and MDMA. Haven't done it since the nuro+'s were splittable though.

IT's even a great combo after the MDMA has mostly worn off, I'm not too sure about the dangers of it however..

For anyone that enjoys codeine I'd recommend dihydrocodeine. A 100mg dose plus half your usual dose of codeine is great. Only do this if you're fairly experienced with codeine though. The high lasts much longer and it's more euphoric IME.
 
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Mr Blonde, can you tell us a bit about timing with CYP2D6 inducers like Promethazine?? How long before dosing do you take them? What happens if you take them after the codeine? Is Promethazine and Doxyalime and diphenhydramine all about the same?
 
dnaenterprises1@ya said:
Mr Blonde, can you tell us a bit about timing with CYP2D6 inducers like Promethazine?? How long before dosing do you take them? What happens if you take them after the codeine? Is Promethazine and Doxyalime and diphenhydramine all about the same?
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I don't think any of those three are CYP2D6 inhibitors. Rather they are all antihistamines. I can't speak for diphenhydramine but promethazine and doxyalmine succinate both work well synergistically (in small doses) with codeine both in improving the experience (though this is subjective - you don't want to be so drowsy you fall asleep after all) and reducing the histamine reaction. Being red and itchy isn't fun :) Those two are pretty long acting so taking them before or at the same time as the codeine should be okay?

Edit: as for being all the same, I'd recommend 5-25mg of promethazine over doxy but that's just me. Restavit is sold as a sleeping aid and Phenergan as an antihistamine if that's any indicator?
 
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