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Codeine Extraction

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Mr Blonde said:
I didn't say it was hard for everyone, I said it was harder for me... I don't know why maybe I've just had bad luck, I'll try again though with your advice because the stuff is a God-send. =D
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You're probably just young. I remember having problems buying AVILS (another type of anti histamine that you can hallucinate from) when I was still in school. I don't' know if you can hallucinate from promethazine but you certainly can get sedated if you take enough, and that's why it' s Schedule3, and why a pharmacist might think you're abusing it.
 
Kompelz said:
If you guys are looking for a good potentiator, you may want to try Travacalm Original:

~Snip~

I've had luck with it; both Dimenhydrate and Hyoscine are known to work, although if you don't like Dramamine, maybe you should avoid it. Personally, I didn't mind it--although it can give you the driest mouth imaginable. It's cheap as too.
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Yeah, I'm not a fan so I'd probably give it a miss. There are a few interesting anti-histamines I'd like to try that have been mentioned in OD but I don't know how available they are in Oz.

atropine said:
You're probably just young. I remember having problems buying AVILS (another type of anti histamine that you can hallucinate from) when I was still in school. I don't' know if you can hallucinate from promethazine but you certainly can get sedated if you take enough, and that's why it' s Schedule3, and why a pharmacist might think you're abusing it.
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That's probably why, I'm only 18 and according to my mother I have 'heroin chic'. =D
 
Dramamine just doesn't do it for me at all. I much prefer Promethazine or sometimes Doxylamine.
I used to have heaps of trouble at pharmacies when I was younger, but I look much more respectable now, (33 now).
 
Dramamine is no longer available in Australia. The closest you can get is Travacalm which also contains hyoscine which is a disgusting antihistamine. It makes me feel bent and wrong and like I have a mouth stuffed with cottonballs. Promethazine is where it's at. The first few times I used it it left me drowsy the whole next day. Now I can take 3 of them and it sedates me only for a few hours. tolerance can be a blessing and a curse.
 
the madcap laughs said:
You said you've been working hard digging trenches.

When i physically have a hard day at work or do a whiles worth of strenuous exercise i get really fucked up on codeine and its not just a coincidence - ive experimented.
There is a very notable difference. Im no doctor but i assume its something to do with metabolism.
Just the other day i was totally physically exhausted from nine hours of tough work and i had one of the best highs of my life, it was just amazing. Fuck you to all who say codeine is a waste of time.
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interesting

perhaps exercise effects (re increases) the levels of enzymes that particulary convert codiene to morphine, maybe it increases the ratio

so instead of 10% -> morphine, 20% of the codiene gets converted to morphine

very interesting

will be going to runs before i take it again

or have sex before hand hell yeah
 
Wiki:

"The conversion of codeine to morphine occurs in the liver and is catalysed by the cytochrome P450 enzyme CYP2D6. CYP3A4 produces norcodeine and UGT2B7 conjugates codeine, norcodeine and morphine to the corresponding 3- and 6- glucuronides. Approximately 6–10% of the Caucasian population, 2% of Asians, and 1% of Arabs[5] are "poor metabolizers"; they have little CYP2D6 and codeine is less effective for analgesia in these patients (Rossi, 2004), although it is speculated that codeine-6-glucuronide is responsible for a large percentage of the analgesia of codeine and thus these patients should experience some analgesia.[6] Many of the adverse effects will still be experienced in poor metabolizers. Conversely, 0.5-2% of the population are "extensive metabolizers"; multiple copies of the gene for 2D6 produce high levels of CYP2D6 and will metabolize drugs through that pathway more quickly than others."

Ok so we want to increase levels of your CYP2D6 enzyme. If you think about it, exercise will get blood pumping a lot more, maybe your liver can produce more CYP2D6 as a result! Or maybe it lowers the other enzymes that turn codeine into useless chemicals hmmm

From BL:

"Recently i have taken 150mg morphine orally without Diphen and felt a little of it but not so much. The next day i took the exact same dose but with about 20mg of Diphen 10 min. (apparently CYPXXX inhibitors act immediately) before taking the morphine and it definitely hit me harder and i was even nodding on that dose, though i imagine the Diphen contributed to that, but needless to say, i definitely felt more pronounced effects of morphine accross the board."

Hmmm I want to try and get my hands on a CYP2D6 inhibitors!
 
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lovebrisvegas said:
interesting

perhaps exercise effects (re increases) the levels of enzymes that particulary convert codiene to morphine, maybe it increases the ratio

so instead of 10% -> morphine, 20% of the codiene gets converted to morphine

very interesting

will be going to runs before i take it again

or have sex before hand hell yeah
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i have no idea what the possible mechanism for this could be, ie intense workout making opiate high better for that day... but i could speculate?

a. natural endorphin levels would be increased after workout having synergistic effects with opiates.

b. upregulation of opiate receptors possibly? i have seen examples of upregulation of specific receptors by exercise (namely insulin receptors) but i doubt it

im not sure about exercises effects on enzymes though... by products of exercise could be co-factors to the mentioned enzymes and possibly make them function better... but i doubt it! that enzyme is responsible for a shitload of things, imagine all the stuff that would start happening everytime we went for a run??

ok just outta curiosity's sake i searched through some literature and found that regular exercise actually attenuates the effects of opiate drugs. they mentioned a cross tolerance between endorphins and opiates (both working on same receptors).

so it wouldn't be hard to imagine leftover endorphins in your system after a long workout (nine hours did he say?) plus extra opiates = greater high.

but, drawback is a quicker/bigger tolerance..!

and hey Kompelz, i remember ya ;)
 
hitomaro said:
i have no idea what the possible mechanism for this could be, ie intense workout making opiate high better for that day... but i could speculate?

a. natural endorphin levels would be increased after workout having synergistic effects with opiates.

b. upregulation of opiate receptors possibly? i have seen examples of upregulation of specific receptors by exercise (namely insulin receptors) but i doubt it

im not sure about exercises effects on enzymes though... by products of exercise could be co-factors to the mentioned enzymes and possibly make them function better... but i doubt it! that enzyme is responsible for a shitload of things, imagine all the stuff that would start happening everytime we went for a run??

ok just outta curiosity's sake i searched through some literature and found that regular exercise actually attenuates the effects of opiate drugs. they mentioned a cross tolerance between endorphins and opiates (both working on same receptors).

so it wouldn't be hard to imagine leftover endorphins in your system after a long workout (nine hours did he say?) plus extra opiates = greater high.

but, drawback is a quicker/bigger tolerance..!

and hey Kompelz, i remember ya ;)
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Either way, my pupils are going to be pinpoints in less than 24 hours =D =D =D
 
lovebrisvegas said:
Hmmm I want to try and get my hands on a CYP2D6 inhibitors!
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Ha, no you don't. ;)

Inhibitors will reduce the amount of CYP2D6 working on the codeine, and you want as much CYP2D6 metabolizing that codeine into morphine as possible.

A CYP2D6 inducer is what you mean, but there aren't many and none are really available.

Regarding the physical work then codeine thing, my guess would be something to do with the endorphin system of the brain and the relaxation that you are getting after a hard day at work. The only times alcohol feels good to me is when I'm really stressed out; any other time I can't stand it.
 
i honestly can't stand the taste of this shit anymore, the thought of it makes me wanna hurl.

so are there any negatives to doing an enema with extracted stuff? im not using crazy filters or anything, i just use a hanky doubled over so im more than positive there's binders/ibu in there..
 
I'm getting to the point of wanting to hurl when I take codeine...

Is there anything that can mask that taste completely?
 
lol, if you think codeine is bad try having to drink 3 cups of piss warm PST every day :P


using choc/strawberry milk to chase it is the best way ime, avoid using fizzy drinks.
 
haha yeh i started out thinking the taste wasnt that bad and id have it straight. then i started to need a chaser usually using coke. now when i drink coke it reminds me of codeine and makes me shudder. now i just mix it heavily with pure cordial. works very well
 
how much water should i use for a cwe with 6 panadeine fortes? ive read 2-3ml per tablet but that seems to be for tablets containing only 8-10mg just wandering if i should maybe double it to about 40ml as 12-18ml doesnt seem like enough.
 
TheWeedMan said:
how much water should i use for a cwe with 6 panadeine fortes? ive read 2-3ml per tablet but that seems to be for tablets containing only 8-10mg just wandering if i should maybe double it to about 40ml as 12-18ml doesnt seem like enough.
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For 6 panadeine forte the amount of paracetamol wouldn't be worth breaking a sweat over. If it was a one-off, a healthy person, not on other medication, could happily eat 6 without adverse effects unless they had an allergic reaction. If you're erring on the side of caution and want to do a CWE then good on you, it's what I'd probably do :)

Use enough water to fully dissolve the tablets. 50-100ml should see you set. Even with 100ml you won't have much paracetamol left after the extraction.
 
If I wanted to try a strong dose of codeine (150-200mg) what brand would you recommend for a CWE? Ive tried a 80mg dose(chemists own, swallowed orally) and found it to be fairly pleasent and wouldnt mind experimenting abit.

Also isnt this stuff ment to be OTC? My local chemist has it on the shelf ready for anyone to pick up.
 
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