Very interesting, I don't know you can expound on this, you mention sulfate and HCL.
I agree with what you're saying here - there are too many drug myths out there, and way too much overly simplistic, commonly spouted explanations for how drugs work. As bad information permeates through drug culture and into mainstream society, it becomes increasingly difficult to challenge wrong information the more widely accepted it becomes. I've had someone who was working as a drug counselor defiantly proclaim that a friend of a friend of his had taken acid and had permanently deranged himself into thinking he was a glass of orange juice. After I challenged this very common urban legend as being fugazi, he became enraged that a drug addict in treatment such as myself, would challenge his confidently incorrect assertion.
Doesn't psilocybin get converted into psilocin in order for it to become active in humans?
Nah. It used to give me nausea when eating whole cacti but from my last peyote experience I didn't even have an hint of it.
I don't know who decided that 2.5-3.5 is the "heroic" range, but to me anything above about 500 mg is getting heroic. If you want to really push things, I suggest working your way up gradually over successive trials. Chances are, you will discover some amount under 1g that is more than adequate, and that beyond that point (as discussed already) you won't get anything more except perhaps a longer duration.
It's very unlikely to be proportional like that. Take alcohol for example. A quick search suggests a human LD50 for alcohol of roughly 0.4% BAC, yet people drink to a BAC of 0.2% all the time and almost never die from it.
There's this online fixation that I've noticed over the years of people with limited experience using psychedelics wanting to push into the 'heroic dose' realm. Not saying that this is what's going on in this instance; I've just noticed that people seem more likely to seek out advice on dosing in this range than I've ever really encountered when discussing in person with other users.
In previous posts I've tended to expound on this particular topic (mescaline activity) to provide clarity & context on my stance. Looking at modern academic research there's no obvious basis for the idea that mescaline behaves like a predrug (Shulgins term). Only in older research do we see this notion being investigated, long before 'the consensus' established the current belief that mescaline is unequivocally the active drug.
Compared to say Psilocin, mescaline interacts quite weakly with serotonin receptors.
Its immediate metabolites aren't active afaik. The as yet uncharacterised metabolites likely occur after several steps (of so-called metabolic activation/"processing"). Implying the participation of enzymes & naturally occurring amines which eventually produces the aminated metabolite(s). I prefer to use Shulgins term predrug since the definition of a prodrug implies it's not psychoactive, whereas mescaline is weakly psychoactive.
I will say that the times I've had the longest come-ups have been when consuming extracts or teas that I've processed myself (ethanol, tea, or acid/base). The times I've had synthetic mescaline which was almost certainly more potent by weight, it has come on quickly.
I don't think that is true and any psychedelic can give you a bad trip
My experiences are solely with synthetic mescaline HCl dissolved in water, as I tend to consume phenethylamines (a few rectal administrations or powder in gel cap when not starting at home aside). As such, they are all pretty comparable.
