Galenika Benzodiazepines need sending to an independent lab. To find out how much product they actually contain. Please Help

[4DQSAR]

OP

Bioequivalence is more tightly monitered that actual dose which as you note has to be within 10%; apart from CDs, but that's a different story.

Benzos are hell. You end up living by the clock... which you will discover in your own time.

Lifeline suggested that given the extreme half-lives and active metabolites of diazepam, for example, once a week was likely still slowly but surely increasing that plasma level.

It can be detected in urine samples for up to 19 days.

Please avoid all of the nitrobenzodiazepines. If the clonazepam is for epilepsy, may I suggest clobazam? It's a unique 1,5-benzodiazepine with only partial cross tolerance to clonazepam and is safer. I have posted the twin acute and chronic toxicicity modes all pharmacutical nitrobenzodiazepines share. The longer half-life of clobazam means [BID] rather than [TID] so is also more convenient for you. But mixing them with any of the 1,4-benzodiazepines is a bit dicey, so be prepared to be faced with choosing one or 'tother. I suggest clobazam the better but as we say, YMMV.

You seem like a sensible person and I think we all value your efforts so on behalf of all BLers, Stay safe - there is only one of YOU.

 

[notsmokeymcpot42088]

Why avoid all nitrobenzodiazepines if they are not in excessive dosages? I remember they are the only benzo you can OD on (almost nitrazepam exclusively) but as at scripted doses what is there to worry about with clonazepam?

I mean look at the LD50 on clonazepam -- and I know mice are different than humans but it is LD50 14,200 mg/kg (rat) -- in dogs ( I believe im going off what I recall you teaching me ) it was substantially lower ......

I don't think anyone has ever overdosed on clonazepam alone, a single case study?

Now let me be clear if you mix with alcohol or other CNS depressants you can get very dead, same with non-nitro benzos.

You have probably deduced this -- but I take klonopin and would like to know if there is any real risk involved, if so I have failed to understand what it is thusfar

haha give me a reason to pitch an equipotent amount of valium or temazepam to the doc -- I would not mind that

I gotta offer an alternative opinion here and say if you medically need benzos they are a blessing, you certainly can find yourself living by the clock if you start recreational use. I do not feel like I am living by the clock with benzos at all.

without them on the otherhand I am counting the hours pass laying in bed awake. that is a worse version of living by the clock imo --- perhaps an extreme example

 

[lost weekend]

Why avoid all nitrobenzodiazepines if they are not in excessive dosages? I remember they are the only benzo you can OD on (almost nitrazepam exclusively) but as at scripted doses what is there to worry about with clonazepam?

I mean look at the LD50 on clonazepam -- and I know mice are different than humans but it is LD50 14,200 mg/kg (rat) -- in dogs ( I believe im going off what I recall you teaching me ) it was substantially lower ......

I don't think anyone has ever overdosed on clonazepam alone, a single case study?

Now let me be clear if you mix with alcohol or other CNS depressants you can get very dead, same with non-nitro benzos.

You have probably deduced this -- but I take klonopin and would like to know if there is any real risk involved, if so I have failed to understand what it is thusfar

haha give me a reason to pitch an equipotent amount of valium or temazepam to the doc -- I would not mind that

I gotta offer an alternative opinion here and say if you medically need benzos they are a blessing, you certainly can find yourself living by the clock if you start recreational use. I do not feel like I am living by the clock with benzos at all.

without them on the otherhand I am counting the hours pass laying in bed awake. that is a worse version of living by the clock imo --- perhaps an extreme example

Alcohol and clonazepam should never be mixed ,like you say they are both depressants ,I would think anyone reading this thread or anyone browsing bluelight would be aware of that
It would be interesting to know the actual confirmed fatalities where only those 2 Substances were involved
I've been extremely lucky and extremely stupid both at the same time regarding that particular combination. I won't say how much of both I have consumed on a regular basis but it's a huge amount

 

[notsmokeymcpot42088]

I will say this when I was prescribed clonazepam at 17 I directly asked how much it would take to overdose (as I thought that would be a "good patient question" -- I was 17 shutup)

The answer the gave, after a solid chuckle was "Probably however much it would take to choke to death" --- Than mentioned any alcohol or other CNS depressants it is a very different story.
**That is definitely not the reason I think it is basically OD proof, doctors are not knowledgeable always***

The many people I have known that tried to off themselves with benzos and woke up 12 to 36 hours later is pretty strong evidence though.

One psycho tried to go out on clonazolam powder and failed -- granted they did get to a hospital with the info of what they consumed provided.... Pretty sure that one woulda went without intervention.

From my understanding there is usually an opiate/oid involved --- but that could just be good PR from big alcohol, I would be interested in the #'s as well.

 

[lost weekend]

I will say this when I was prescribed clonazepam at 17 I directly asked how much it would take to overdose (as I thought that would be a "good patient question" -- I was 17 shutup)

The answer the gave, after a solid chuckle was "Probably however much it would take to choke to death" --- Than mentioned any alcohol or other CNS depressants it is a very different story.
**That is definitely not the reason I think it is basically OD proof, doctors are not knowledgeable always***

The many people I have known that tried to off themselves with benzos and woke up 12 to 36 hours later is pretty strong evidence though.

One psycho tried to go out on clonazolam powder and failed -- granted they did get to a hospital with the info of what they consumed provided.... Pretty sure that one woulda went without intervention.

From my understanding there is usually an opiate/oid involved --- but that could just be good PR from big alcohol, I would be interested in the #'s as well.

Yeh without any figures for either combos opiates and benzos are a lethal mix
Everyone is different, my tolerance for benzos was through the roof and I mixed alcohol and clonazepam every night
On weekends quite often a bottle of malt whisky plus a few beers
I guess I've just been very lucky

 

[notsmokeymcpot42088]

I have been pretty fortunate in those regards too. Not a big drinker -- but benzos and opis definitely count.

I am guessing it is a little less luck and a little more knowing how your body reacts specifically and not pushing those boundaries

my tolerance was idk unheard of through the roof and I had to be real careful about adding a benadryl even --- now it is literally like less than 1% of what it use to be; so a drink now and than keeps the PAWs and urge to "Use benzos recreationally" which just takes too much to do on a script imo -- at least if you dependent to said scrpt.