You can get around vasoconstriction with Agmatine around 250 to 400mgs everyday it also lowers your tolerence to pretty much every drug. I find less is better with that one were not going for dissociative effects like a lot people do lol. You can get like 3 and half years worth of it in a jug for like 40 bucks and measure it out yourself. Also helped my depression and my focus problems and made everything less dark and more vibrant.
Yeah that supplement was a life saver for fluro phenibut withdrawal dropped my blood pressure way down and also helped the anxiety associated with it.
Oh yeah, twice it resulted in large amounts of crystal pregabalin getting delivered to the people who lived there after I moved out. It's like a strange curse.
Yo sorry to double post but have you ever overdosed on floribut? One time I left some out on a tray, then insufflated 100mg and it damn near killed me.
I may have lol, that shit had me feeling like I was on a barbituate and I would take a scoop every 4 hours or so lol. Then after I went off it and tried taking it again it made my blood pressure shoot up 160+. I had celiacs disease at the time though without realizing it and was eating wheat I think that had a factor in my blood pressure. When ever I eat wheat it makes my blood pressure shoot up besides the hives and stomach isseus.
Would recommend it mate honestly, I fucking love the stuff. I know supplements can be over blown but this stuff is worth having in a toolbox.
Yeah I had a huge jug of it and would measure it out on a scale and usually take around 250 mgs most of the time upto 400 mgs sometimes. anything over that made me sleepy through out the day. Yeah it works pretty well, when I first took it I took like 3 grams discovered lower doses offered more benefits. I honestly like measuring it out better because you can experiment with different doses. If your going through withdrawal like I was those higher doses are gonna be more beneficial.
Black seed oil and agmatine saved my ass early on in my massive 7oh taper.
I have done some silly runs with DHC and even codeine, using 3-4 days a week, dosing twice a day, and I do think Agmatine has also saved my ass so I could just hop off no issues
Besides withdrawal it works so well for depression just makes colors vibrant and less dull.
My doses are crazy tbf, I don’t really need to take that much but it’s still none impactful as the half life is short (2 hours I believe)
pubmed.ncbi.nlm.nih.gov
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That's great stuff. Since it appears to have psychoactive effects that appear to be quite potent at higher doses, why do you suppose it is still OTC and basically not regulated?? Is it somehow flying under the radar ?? Do you think it's inevitable that it will get taken off the shelves at some point , if not just for the reason of pharmaceutical companies wanting in on it. (Then again; DXM is still OTC and not regulated so there's that...hmmm.) thanks for your prospective!My doses are crazy tbf, I don’t really need to take that much but it’s still none impactful as the half life is short (2 hours I believe)
(Not a recommendation just my experience)
250-500mg I’d say best for Vasodilation, Augmenting Stims and Opioids (for blocking tolerance with doses, it may kill some recreational effects but it will increase analgesia and medicinal value of stims and opioids)
500-1000mg- is for severe depression, sedation and anxiety relief, many report finding this even too sedating for the day YMMV
1000mg+ - stim comedowns, sleeping, and dissociative experiences.
I’ve always been an all or nothing person. I could benefit from some day dosing, I will do it eventually but man I love taking 3 grams at night.
I know your sold but just linking some studies as I’m so passionate about Agmatine.
Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report - PubMed
There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective...
The therapeutic and nutraceutical potential of agmatine, and its enhanced production using Aspergillus oryzae - PubMed
Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α<sub>2</sub>-adrenergic and imidazoline receptors in the...
Agmatine, a potential novel therapeutic strategy for depression - PubMed
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence of up to 20% worldwide. It is responsible for more years lost to disability than any other disorder. Despite the fact that current available antidepressant drugs are safe and effective, they are far from...
Agmatine: clinical applications after 100 years in translation - PubMed
Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has the demonstration of agmatine biosynthesis in mammals revived research, indicating its exceptional...
