RCs Do any good legal highs still exist ??

[CarryBagMan]

No sir, I regret to inform you that cocaine does not count. Nice try though.

 

[KurtAurelius]

That's great stuff. Since it appears to have psychoactive effects that appear to be quite potent at higher doses, why do you suppose it is still OTC and basically not regulated?? Is it somehow flying under the radar ?? Do you think it's inevitable that it will get taken off the shelves at some point , if not just for the reason of pharmaceutical companies wanting in on it. (Then again; DXM is still OTC and not regulated so there's that...hmmm.) thanks for your prospective!

I think because it’s still a “only” a metabolite of arginine, psychoactive potential isn’t really mentioned with aminos and certain herbal stuff. People would disagree with me but I’m of the opinion some of this stuff is psychoactive but I’m very sensitive.

I believe there is likely inertia with any developments on Agmatine because it can’t be patented but don’t quote me on that.

I think it won’t be axed, but you never know. I’d be writing letters to whoever saying this is a medicine for me and without it I wouldn’t be good lol..

 

[Allylbenzene]

This agmatine sounds like a miracle substance. I must look into it. I am grateful for the folks in this thread bringing it to my attention. Sounds like the dosing can vary a lot, depending on what your aim is for the substance.

Reports on agmatine do exist if you look around. People use it for all sorts of purposes - medicinally, recreationally etc.

Feels exactly like a long lasting ketamine for me. Very obvious it is a NMDA receptor antagonist. It’s supposed to effect calcium channels similarly to pregabalin and for me doses as low as 250mg absolutely increase the effects of pregabalin. I’d go as far to say agmatine is very strong in its own right, especially as an NMDA antagonist.
reddit.com/r/gabagoodness/comments/o51plu/does_agmatine_have_any_recreational_properties_or/

So someone here recently recommended me to mix Agmatine Sulfate with Kanna extract and this truly changes the game in relation to the rush. As we all know, sometimes the rush can be a bit anxiety-inducing, unsettling, etc, but when adding Agmatine Sulfate (I use around a gram 1 hour before) not only makes the whole Kanna experience cleaner and more euphoric, but smoothens out the rush in a way that makes it extremely orgasmic, it feels so close to the comeup of a MDMA experience, a love-filled I euphoric I want to hug the world empathogenic type of experience, with little to no discomfort added in relation to it.
reddit.com/r/Kanna/comments/18qr34z/how_to_smoothen_the_rush_agmatine_sulfate/

I just started taking Agmatine to lower my tolerance to other substances, and I heard that it also effects the Cannabanoid Receptors, but i didnt think it would do THAT much. I took a single evening dose of 500mg, a little later took a few hits, then another hour an a half i smoked 2 more hits, and then all of a sudden I was SO HIGH i could barely walk or talk. It felt like I took a whole edible plus some. And mind you, I smoke everyday just about. This is one promising supplement it seems. There was nothing on this sub on the search of agmatine so figured I'd add something to it for others wondering the same.
reddit.com/r/Marijuana/comments/zt0afy/agmatine_sulphate_supplement_cannabis_wow/

In essence, I've been doing 2.6 grams of Agmatine once a week since the beginning of November/December.

It shares a similiar, primary, MOA (mTor & AMPA) as ketamine in terms of neurogenesis, and it has some pretty pleasant 5-HT2A agonistic actions making it as an excellent insight tool (no hallucinations though).
...
Yet distinctly feels very much like a psychedelic in terms of time-dilatation, emotions, and insight. A topic discussed in one of the links below.
reddit.com/r/Nootropics/comments/7t5779/agmatine_metamorphosis/

It also boosts the production of allopregnanolone, a neurosteroid that acts as a GABA(A) positive allosteric modulator amongst other things.

Agmatine had a widespread impact on gene expression and metabolic profiling including (a) activation of PPAR-α
‐ https://doi.org/10.1074/jbc.M113.544726

The activation of PPAR-α may exert neuroprotection through the regulation of genes involved in several signaling pathways and those encoding proteins engaged in cholesterol transport into mitochondria and its metabolism to neurosteroids. Cholesterol is the substrate for neurosteroids, and its level may influence the synthesis of progesterone, allopregnanolone, and other compounds
- https://doi.org/10.3390/ijms25137106

Activation of PPAR-α by the endocannabinoid congener N-palmitoylethanolamine regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripheral biosynthesis of allopregnanolone
- https://doi.org/10.1016/j.biopsych.2019.02.006

It looks like aspirin also activates PPAR which boosts steroidogenesis and BDNF amongst other things, just like agmatine and palmitoylethanolamine (mentioned above).

These findings highlight a property of aspirin: stimulating hippocampal plasticity via direct interaction with PPARα.
10.1073/pnas.2502115122

PPARα Serves as a New Receptor of Aspirin for Neuroprotection
...
Previously, it has been shown that PPARα directly binds to the promoter region of CREB, a master regulator of hippocampal formation of memory, promotes the expression of CREB and CREB-dependent neurotrophic factors. Brain-derived Neurotrophic Factor (BDNF), a downstream target of CREB has been long known to directly stimulate the growth and function of hippocampal neurons.
10.1002/jnr.24561

 

[Esperighanto]

Any luck with those? Are you sporting a 10-incher now?

They definitely maintain a supremely abnormally erect state for a dangerous span of time, absolutely do not mix them with MDMA like I did, but also goddamn that was a wild night.

 

[CarryBagMan]

My doses are crazy tbf, I don’t really need to take that much but it’s still none impactful as the half life is short (2 hours I believe)

(Not a recommendation just my experience)

250-500mg I’d say best for Vasodilation, Augmenting Stims and Opioids (for blocking tolerance with doses, it may kill some recreational effects but it will increase analgesia and medicinal value of stims and opioids)

500-1000mg- is for severe depression, sedation and anxiety relief, many report finding this even too sedating for the day YMMV

1000mg+ - stim comedowns, sleeping, and dissociative experiences.

I’ve always been an all or nothing person. I could benefit from some day dosing, I will do it eventually but man I love taking 3 grams at night.

I know your sold but just linking some studies as I’m so passionate about Agmatine.

Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report - PubMed

There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective...

pubmed.ncbi.nlm.nih.gov

The therapeutic and nutraceutical potential of agmatine, and its enhanced production using Aspergillus oryzae - PubMed

Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α₂-adrenergic and imidazoline receptors in the...

pubmed.ncbi.nlm.nih.gov

Agmatine, a potential novel therapeutic strategy for depression - PubMed

Major depressive disorder is the most common psychiatric disorder with lifetime prevalence of up to 20% worldwide. It is responsible for more years lost to disability than any other disorder. Despite the fact that current available antidepressant drugs are safe and effective, they are far from...

pubmed.ncbi.nlm.nih.gov

Agmatine: clinical applications after 100 years in translation - PubMed

Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has the demonstration of agmatine biosynthesis in mammals revived research, indicating its exceptional...

pubmed.ncbi.nlm.nih.gov

I was wondering if anyone could recommend a good source for Agmatine or if just ordering from what they sell on Amazon, ebay would be fine. (I assume asking about sources on this one should not be a problem since it's OTC.)

Also the way Agmatine is marketed cracks me up, in that none of the positive aspects that are commented on here are anywhere to be found on the packaging. It's being promoted as a "Nitric-Oxide Booster" and "Post-Workout Formula" ...I mean rather broad and nebulous concepts.

Lastly does this compound have any similarities to Memantine?? I know they both affect NMDA receptors but beyond that is there anything significant?? Thanks folks !!

 

[Allylbenzene]

I was wondering if anyone could recommend a good source for Agmatine or if just ordering from what they sell on Amazon, ebay would be fine.

One time I got nutricost agmatine, another time it was some unbranded powder product.

Also the way Agmatine is marketed cracks me up, in that none of the positive aspects that are commented on here are anywhere to be found on the packaging. It's being promoted as a "Nitric-Oxide Booster" and "Post-Workout Formula" ...I mean rather broad and nebulous concepts.

It does have relevant nitric oxide effects tbf. It just also happens to have dozens of others including nmda antag and sigma-1 agonism like memantine. DMT is also a sigma-1 agonist.

But it's got a totally different character to memantine.