4DQSAR
Bluelighter
- Joined
- Feb 3, 2025
- Messages
- 5,490
BTW to be clear, I can only guess but I think the reason related compounds are misrepresented in Mandrax tablets is because the key precursor used in methaqualone synthesis is watched.
But the fact that Mandrax abuse has continued in South Africa for so long sort of suggests that if vaped, it produces and extremely potent but short-lived high. I suggest this is because like crack cocaine, it concentrates the drug in the brain very quickly but rapidly undergoes redistribution.
So it likely produces compulsive redosing.
But never lose sight of the fact that even the original research team tested hundreds of related compounds and went with the best - methaqualone. So unless you actually look at research that took place two decades later, nobody identified a 'better' alternative. Even the one example I explicitly named (HQ-355) isn't all that much more potent, is much harder to make and so is unlikely to turn up as an RC. Oh, and to top it all, it's an example of an 'island of activity' so if it were to be explicitly legally controlled, you can't then produce homologues.
So even IF I saw someone claiming to offer HQ-355, I would be dubious. Just as I was when I saw ligands being sold at a lower price than the presursors actually cost. So they now recognize that users don't really know what to expect so don't even know if something was misrepresented.
In short, we now have a market place with no robust review methodology, no instrumental analysis and no physical address, so if nothing else you can go in person to complain. In such a market place, Grisham's law isn't optional, it's inevitable. Mystery powders are incompatible with a long and healthy life.
But the fact that Mandrax abuse has continued in South Africa for so long sort of suggests that if vaped, it produces and extremely potent but short-lived high. I suggest this is because like crack cocaine, it concentrates the drug in the brain very quickly but rapidly undergoes redistribution.
So it likely produces compulsive redosing.
But never lose sight of the fact that even the original research team tested hundreds of related compounds and went with the best - methaqualone. So unless you actually look at research that took place two decades later, nobody identified a 'better' alternative. Even the one example I explicitly named (HQ-355) isn't all that much more potent, is much harder to make and so is unlikely to turn up as an RC. Oh, and to top it all, it's an example of an 'island of activity' so if it were to be explicitly legally controlled, you can't then produce homologues.
So even IF I saw someone claiming to offer HQ-355, I would be dubious. Just as I was when I saw ligands being sold at a lower price than the presursors actually cost. So they now recognize that users don't really know what to expect so don't even know if something was misrepresented.
In short, we now have a market place with no robust review methodology, no instrumental analysis and no physical address, so if nothing else you can go in person to complain. In such a market place, Grisham's law isn't optional, it's inevitable. Mystery powders are incompatible with a long and healthy life.

