Opioids SR-17018 Is the future of opioid detox medication. Painless easy cheat to avoid withdrawal that is too good to be true, but it is legit and real.

[4DQSAR]

Where does one acquire SR-17018? I don't see it online or on store shelves?

I regret to inform you that Bluelight has a 'no sources' policy.

 

[Mazy_May]

It absolutely is possible! There are more SR-17018 user reports to be found online all the time detailing successful and unbelievably easy/pain free experiences using SR-17 to fully detox off opiates

Sadly it's just kind of an obscure thing still, and unfortunately it is not really easily accessible. I'm pretty sure any kind of detailed discussion on sourcing is against the rules around here but I think I can say that I am aware that this RC is currently in stock with several legit vendors from a few different countries.

Hi there I am a new user here and I'm very interested. In this topic I'm learning more about it and where I can go to just study it or see it. You say it is obscure if you could elaborate more on that that would be greatly appreciated. I'm trying to learn the lingo around here, I wish I had a manual to understand the sling that is being used to study these topics. Looking forward to hearing from you.

 

[Mazy_May]

I regret to inform you that Bluelight has a 'no sources' policy.

 

[Mazy_May]

do you all use discord? I'm interesting in studying and researching the possibilities to help me understand the deeper research on such things that were mentioned. I'm just in the mood to learn how to get around on Reddit and other links that would might help me understand the chemistry and reactions to compounds of SR-17018, and how it affects the nervous system.

 

[4DQSAR]

I posted a whole bunch of links to research into SR-17018 some months ago. I forget which thread but obviously one started to discuss the compound. It was difficult to find any independent research and as I noted at the time, anyone who develops a candidate will obviously design studies to show that candidate in the best light.

But I think the most important takeaway is that their is already a biased MOR ligand in clinical use in some nations. To whit oliceridine (Olinvyk) but the lack of oral bioavailability limits it's use into in-patient settings. It's makers have attempted to find an orally active analogue but as far as I know, haven't succeeded yet.

 

[Mazy_May]

I posted a whole bunch of links to research into SR-17018 some months ago. I forget which thread but obviously one started to discuss the compound. It was difficult to find any independent research and as I noted at the time, anyone who develops a candidate will obviously design studies to show that candidate in the best light.

But I think the most important takeaway is that their is already a biased MOR ligand in clinical use in some nations. To whit oliceridine (Olinvyk) but the lack of oral bioavailability limits it's use into in-patient settings. It's makers have attempted to find an orally active analogue but as far as I know, haven't succeeded yet.

Can you please tell me how to view your threads that you created? Is there a translation page that I could see that would help me better understand what a candidate means and what the lack of bio availability means? I am currently studying these compounds, and it's very difficult for me to understand the terms, and what they translate to.

 

[Dr. Morphine]

Then they'd have no excuses not to prescribe opiates...if there was something that could help people stop if it got out of hand.

 

[Mazy_May]

That is true! I would like to where and how to subscribe so I could get the research and help that I need. I just also created an account on discord (mazy_may). Wish I was better at using this platform. Period

 

[Mazy_May]

I say this with a sincere lack of certainty but didn't later research suggest that rather than being a biased ligand, SR-17018 was, rather, a low efficacy ligand? I'm almost sure I read a later paper that suggested that being the case.

After all, brophine has turned up on the black market and I'm unclear if the researchers found it to be the LEAST biased when in fact it simply has the highest efficacy of the series.

CC brorphine - I've certainly come across patents in which that chiral methyl side-chain is resolved and the two enantiomers have different activities. In fact, I think the patent was actually trying to find NOP ligands. Uncertain if NOP affinity was covered by that original research.

Don't get me wrong, nobody would be more pleased than me if it turns out there is a new medicine that allows people to bypass the physical dependence to opioids. Obviously psychological addiction is a seperate issue.

I would be a good candidate for using psychedelics for my depression. I was able to do this when I was in high school, but trying to find information on that and where to go to obtain something that would help me with my depression in my addictions to opioids I've been thinking about Growing my own, but that's gonna take a lot of effort and I would just rather go to the link and get my success there.

 

[reyden00]

L'SR-17018 è una sostanza chimica oppioide sperimentale la cui particolarità è che non agisce sulla "B-arrestina" come altri oppiacei, ma sulla proteina G. Sarò onesto, non so esattamente cosa significhi, ma se lo sapete, su Google potete trovare alcuni articoli di ricerca su questa sostanza.

Quello che so è che assumere SR-17018 per un paio di settimane permette di interrompere l'assunzione di oppiacei senza sperimentare sintomi di astinenza. In quelle due settimane di assunzione, la tolleranza tornerà quasi a zero. Al punto che esiste un serio rischio nell'uso di oppiacei dopo aver assunto SR, e molti hanno affermato di aver subito overdose perché non si erano resi conto di quanto fossero diventati sensibili agli oppiacei a causa dell'assunzione di SR-17018.

Sono stato dipendente dagli oppiacei per 5 anni praticamente senza sosta. Ho provato di tutto per smettere. Non sono mai riuscito a superare la disintossicazione a causa dell'ansia folle con cui non riuscivo proprio a convivere... il tempo sembrava fermarsi e un giorno era un'intera vita di agonia.

Quindi, dopo tutti gli innumerevoli tentativi di disintossicazione, metodi, trucchi, integratori, farmaci, ecc. che ho provato per disintossicarmi dagli oppiacei, non credevo che l'SR-17018 fosse il cheat code indolore per la disintossicazione che si diceva fosse. Anche dopo averlo acquistato, non ci credevo. Anche dopo aver iniziato ad assumerlo, e in effetti mi impediva almeno di entrare in astinenza mentre lo assumevo.

Dopo alcune settimane di assunzione di SR, quando finalmente ho smesso di prenderlo, aspettavo di sentire i sintomi dell'astinenza arrivare da un momento all'altro. Ma non sono mai arrivati. Credo davvero che questa sostanza sia il futuro della disintossicazione. Le aziende farmaceutiche faranno tutto il possibile per impedirlo, così da poter continuare a vendere pillole di Suboxone o metadone a quante più persone possibile per il resto della loro vita, invece di una cura disintossicante indolore che richiede solo poche settimane e meno di mezza dozzina di grammi. Ma prima o poi ci arriveremo.

Scrivo questo post solo per aiutare a diffondere la notizia. A volte è un po' complicato reperire questa sostanza, non ce ne sono molti lotti prodotti nei laboratori cinesi, da dove solitamente provengono i RC. Più persone ne sono a conoscenza, ne discutono, ecc., meglio è.

ciao, potresti aiutarmi a reperire un fornitore affidabile con prezzi ragionevoli e non quei siti per ricerca? Sono disperato e non so più come fare, 20 anni tra metadone eroina ecc...ti ringrazio, scrivimi pure in privato se puoi..

 

[4DQSAR]

I would be a good candidate for using psychedelics for my depression. I was able to do this when I was in high school, but trying to find information on that and where to go to obtain something that would help me with my depression in my addictions to opioids I've been thinking about Growing my own, but that's gonna take a lot of effort and I would just rather go to the link and get my success there.

I couldn't possibly give you any advice on the safety of brorphine. I presume it's the raecemate being sold wheras the papers I read resolved the product and assigned NOP affinity to both enantiomers.

We have no proper human data on the stuff so who knows how big the TI is. Certainly we have seen fatalities.

 

[Deleted member 585202]

How does this work for bupe dependence? Same? Or does it not have the power to displace bupe?

 

[4DQSAR]

How does this work for bupe dependence? Same? Or does it not have the power to displace bupe?

I posted a paper in which it was compared with buprenorphine in primate models of dependence. Buprenorphine was the superior treatment.

I know I have mentioned this several times before but when buprenorphine was first trialled for the treatment of opiate depencence, it was only prescribed for 7-14 days.

Now it doesn't take a genius to figure out that a medication that is only prescribed for a week or two isn't going to be a 'blockbuster'. It's going to be a niche medication only prescribed by specialists.

But now people are being 'parked' on buprenorpine in exactly the way people were being 'parked' on methadone.

I also wonder if those prescribed buprenorphine really know how potent it is. As an analgesic just 100-200ug are needed (it's estimated to be about 37.5x more potant than M as an analgesic) so when someone mentions they are on 16,24 or even 32mg/day, to me, that seems an insanely high dose.

For the treatment of pain buprenorphine is usually prescribed [TID] and I admit I don't know if any of the new formulations for dependence provide modified release because I assume those huge doses are chosen on the basis that even 23 hours after consumption, their is still enough in the body to blockade other opioids (or at least blunt their effects rendering them non-euphoric.

BTW While I'm at it, there is an acetyl ester derivative of R-4066 (a semi-rigid methadone analogue) which is not only some x106M in potency but which has a T½ of something like 18.4 hours and unlike ORLAAM, isn't cardiotoxic. It's work from the 1960s but now fentanyl is so prevelent in North America in particular, I would say the time has come to consider such compounds. Synthesis IS costly... but at scale, I don't think it's more than two hundred times that of methadone.

 

[Deleted member 585202]

Buprenorphine was the superior treatment.

How so? How did they quantify that?

Bupe had less relapses than SR-107? Less withdrawal scale symptoms?

I know I have mentioned this several times before but when buprenorphine was first trialled for the treatment of opiate depencence, it was only prescribed for 7-14 days.

Personally, I think that is the best way to take bupe. Its obviously riskier from a relapse and retention rate perspective, but I think its the best long term solution.

Being dependent on bupe sucks. It keeps me in that addict mindset, you know? Plus, are you truly sober at an AA meeting if you're on bupe? Quite the conundrum.

 

[4DQSAR]

How so? How did they quantify that?

Bupe had less relapses than SR-107? Less withdrawal scale symptoms?



Personally, I think that is the best way to take bupe. Its obviously riskier from a relapse and retention rate perspective, but I think its the best long term solution.

Being dependent on bupe sucks. It keeps me in that addict mindset, you know? Plus, are you truly sober at an AA meeting if you're on bupe? Quite the conundrum.

They used primate models to elicidate preference.

When finally introduced into substitution (several decades after discovery), it's high affinity likely made it better than methadone but fentanyl and nitazenes have somewhat altered that calculations.

As I noted, that R-4066 derivative would likely blunt even potent opioids. But I don't know of any research as R-4066 in substitution therapy - especially not we are seeing highly potent compounds popping up in many nations. I don't know why NOBODY has at least suggested it. Maybe because Janssen mentioned detoxiication in the original patent?

 

[DrChivago]

Le goated fo sho.

It actually fixes people rather quickly by avoiding recruitment via b-arrestin pathway and hitting smack right on the MOR location, as a g-protein ligand for the mu-opie receptor. Pretty rad shit honestly. Even crazier they haven't the foggiest how the "repair" mech works during this process. But it sure AF does, because I enjoy being stupid and dabbling in Le Numero Quatro(after staying off for 6 mon after SR) and lemme speak on it. If I do more than 30mg of H or 20mg of Methadone...I be Lil Yack no Kodak. AND IMHO, it almost has a psychedelic aura to it. Well, maybe not trippy...but something is going on very SSRI'ee when at its peak efficacy. It genuinely makes you feel... "hopeful", and not anguished like "FML IGKM"

It really does repair yo shit. Remember way back when you would take some tabs or oxy-- get fukt up wit the itches and have that glow? Well...its baaaaack. But this takes Shaolin monk discipline to not develop dependence. ONE NIGHT ONLY w/big gaps in between full of yola and scante. You have to look at opiates indifferently like you would an aspirin without a headache. It's some special stuff no cap. However, I hate to piss le communal Cheerio bowl, but the thing about this Wonderful little compound is that it will never make it to market. It will remain niche or get the bureaucratic door slammed on it as an analog of Brorphine(technically Chlorophine)... for one reason. Dolla bills y'all...

THERE IS NO MONEY IN CURES...ONLY TREATMENT. Hell, with a smidge of recovery implementation this shit akshully werks! And boy Houston sure as shit will have a problem with that....

I mean orangey is what? 8 billy annual and Old pinky is going HAM mode and hitting a 5 billy stride gaining on its ass quick son. Sheeeitit... it hasn't seen a glow up in decades, but thanks that casa-grown mexifetty and precipitated withdrawal we might have us a done 2.0 redux. That is 13 BILLION A FN YEAR BROS... Thats get your ass chopped up and fed to pigs money they'd be losing if that bish hit the shelves.

Now in about 10... Maaaaaybe after the patent runs out and Scripp's says fuck it. Then the Big Farmy will scoop it , market as a niche mega expensive treatment for recovery centers. Yeah, for absolute redonkulous prices too. Thats about it, really. I just hope the DEA doesn't get a hard on for it. That would just be a real Richard move. I could see them clownfuks scheduling it as an analog of Fent, lol.

FFS...can it just stay right TF where it's at? Dead ass. Im good wit it. All ya gotta do is call the Chinese Lab that supplies literally everyone and buy it direct.

Easy Peasy Mac n Cheeseee

Long live SR17018, and long flourish this amazing pharmaceutical to all who need it!

SMTBS

 

[DrChivago]

They used primate models to elicidate preference.

When finally introduced into substitution (several decades after discovery), it's high affinity likely made it better than methadone but fentanyl and nitazenes have somewhat altered that calculations.

As I noted, that R-4066 derivative would likely blunt even potent opioids. But I don't know of any research as R-4066 in substitution therapy - especially not we are seeing highly potent compounds popping up in many nations. I don't know why NOBODY has at least suggested it. Maybe because Janssen mentioned detoxiication in the original patent?

I say chap.... I do admire your thoroughness and dedication to genuine information. I lurked on many of your responses. I confess

Una pregunta señor? have you ever heard of SB-334867

It looks actually really interesting for alcoholism, Cocaine addiciton, Opiod addiction, Obesity and more...shit... I mean, the applications are friggin ridiculously broad from the little info I read. Seems like the one ya think?

Didn't know if you had any thoughts on it, or not... since you seem to know your shit and all, respectively.

SMTBS

 

[General alcazar]

Withdrawals are a too convenient a punishment. The powers that be, the moral majority, Nancy Regan, and all the other iterations of the war on drugs, they all want us to suffer for our sins. Giving opiate addicts an easy out would undermine the stick. It would also harm the huge “drug treatment” industry, delegitimize their treatment centers that force addicts to work with no pay while treating them like cattle, and generally prevent being able to advantage of, and victimize, a vulnerable population. I wonder why ibogaine hasn’t been more mainstream, or for that matter tabernanthalog? It’s sad, but no one wants you to get well. They want you to be exposed and vulnerable, so they can pick every morsel of flesh from your afflicted bones. I hope SR17018 works, and becomes available, but I think, at best, it will always be grey market, at best.

 

[DrChivago]

Withdrawals are a too convenient a punishment. The powers that be, the moral majority, Nancy Regan, and all the other iterations of the war on drugs, they all want us to suffer for our sins. Giving opiate addicts an easy out would undermine the stick. It would also harm the huge “drug treatment” industry, delegitimize their treatment centers that force addicts to work with no pay while treating them like cattle, and generally prevent being able to advantage of, and victimize, a vulnerable population. I wonder why ibogaine hasn’t been more mainstream, or for that matter tabernanthalog? It’s sad, but no one wants you to get well. They want you to be exposed and vulnerable, so they can pick every morsel of flesh from your afflicted bones. I hope SR17018 works, and becomes available, but I think, at best, it will always be grey market, at best.

Nail --> Head.

yeah again no money in cures... If SR were mass produced and gram bagged out in clinics I would estimate a 50% recidivism rate. Do you know how must lost revenue and infrastructure collapse that would create? It would be an economic vacuum. Same reason they havn't even begun to look at reversing judgment on NV pot offenders. You're talking a Kirby or Dyson of mad dollas son.

we are soooo cooked here. its not that the system is broken. It's that it works exactly how it was supposed to when you've learned that you kinda just kinds stop donating fks... especially if you've been introduce to it unwillingly.

 

[4DQSAR]

I don't think anyone even suggested that SR-17018 helped ADDICTION. Most people are able to detoxify from opioids given the appropriate treatment but the long-term outcomes are not exactly great with 70-90% of clients relapsing within a year.

I have also mentioned that we don't know if SR-17018 works repeatedly nor what the effects are if it's mixed with a 'classic' MOR ligand. From what I have read, it isn't that potent so I'm unsure if it would provide relief to anyone dependent on extremely large amounts of opioids or those who use opioids with extremely high activity.

In one trip report someone mentioned taking a large (for them) dose of SR-17018 and noted that the subjective effects were more or less the same as classic opioids. So is SR-17018 addictive in it's own right? The human studies weren't actually testing those things. The stuff was originally investigated as an alternative to oxycodone and it proved not to be very good in that role.