Whats the best drug combo of All time ?

[Uden]

Heroin, and um.. hmm let me think...

Heroin. Best combo ever!

(Sorry. My lame attempt at being funny.)

I will say there was one time someone spiked my (probably fent) with ice, and I went and banged it. Thought they screwed up and gave me pure shit or something. (I had never done ice before that, haven't done it since that short stint ended.) Scared me a bit. Hit me like a brick wall. But after I settled down it was nice. I even asked for it a time or two after that, but after that third day of no sleep I knew it wasn't for me. Sleep is too precious a commodity.

 

[marcoman]

I've not heard of Demerol being used in hospitals or prescribed, but maybe it's just exceptionally rare. How would you compare it to other opioids, experientially?

I was 24 years old, had a serious kidney problem and surgery. The only drugs I played with at that time were MJ, LSD (suagr cubes, blotter etc) and mushrooms. So it was my first experience with something "heavy" like that. I was in the hospital 3 weeks and getting hit up every 6 hrs post surgery. I was weaned off because I was having horrible withdrawal problems. Mostly evil, ugly, scary hallucinations. I was losing my mind and thought it was going to be permanent.

I wondered about it too (Demerol) and after I wrote that comment I looked it up online. It's rarely if ever used now as it had a ton of bad side effects (so it says) I've never had any opioid exprience close to it. It was more trippy-like...as I mentioned it felt like I had no body. It was the most wonderful experience ever. No visuals or LSD reactions really, just total bliss. And I've tripped probably 100 times or so (back in the day), synthetic and straight plants, mushrooms, peyote etc.

It was some freakyass stuff. It was much like a Near Death Experience and like the videos I watch. I was def 'at times outside my body - floating and saw a silver glowing cord attached to my body laying in the bed. At times my soul/spirit would slam back into my body. It was violent and disturbing but I still felt ok. I'd cycle on and off like that on a regualr basis. Some readings I've done call that Astral Projecting. I think thats a proper description. Maybe I was on the edge of death? back and forth multiple times?

 

[Esperighanto]

I was 24 years old, had a serious kidney problem and surgery. The only drugs I played with at that time were MJ, LSD (suagr cubes, blotter etc) and mushrooms. So it was my first experience with something "heavy" like that. I was in the hospital 3 weeks and getting hit up every 6 hrs post surgery. I was weaned off because I was having horrible withdrawal problems. Mostly evil, ugly, scary hallucinations. I was losing my mind and thought it was going to be permanent.

I wondered about it too (Demerol) and after I wrote that comment I looked it up online. It's rarely if ever used now as it had a ton of bad side effects (so it says) I've never had any opioid exprience close to it. It was more trippy-like...as I mentioned it felt like I had no body. It was the most wonderful experience ever. No visuals or LSD reactions really, just total bliss. And I've tripped probably 100 times or so (back in the day), synthetic and straight plants, mushrooms, peyote etc.

It was some freakyass stuff. It was much like a Near Death Experience and like the videos I watch. I was def 'at times outside my body - floating and saw a silver glowing cord attached to my body laying in the bed. At times my soul/spirit would slam back into my body. It was violent and disturbing but I still felt ok. I'd cycle on and off like that on a regualr basis. Some readings I've done call that Astral Projecting. I think thats a proper description. Maybe I was on the edge of death? back and forth multiple times?

Iirc demerol can increase risks of serotonin syndrome. I'm unfamiliar with the pharmacokinetics at play that could cause that, but I wonder if they're related to the experience you had.

 

[Deleted member 585202]

All opioids can cause SS, but some clearly more than others (e.g. tramadol). There are even case reports of therapeutic doses of loperamide causing SS by increasing peripheral serotonin which reaches the brain.

During my experience with SS, I couldn't focus on anything CEV or spiritual, I felt like I had taken the most fucked up stimulant drug ever invented and was enveloped in a world of symptoms and anxiety.

 

[Babygirl25]

May I ask, do oxycontin also cause SS? Are we talking the same thing as people get when coming off of SSRIs? If you're saying yes then that's worrying. Os it just a very similar det of symptoms or is it actually SS? How would I know that I'm suffering from it? TIA.

Babygirl. X

Ps. If you're taking an SSRI as well as opiates can this either increase the chances of this happening or make it worse?

 

[vision conquest]

Yeah, six amps a day.. the doctors were naive back then. Mind you my Dr was a realist as he knew if he didn't give me that script I'd buy street drugs that might be cut to fuck, although back then they were suite pure, just so many that could be lethal still on the market and easily available.

Today I'm prescribed pregabalin 300mgs every twelve hours. We 60 mgs of oxycontin s/r and 20 I/r oxynorm for breakthrough pain. I rarely take anything else. Well maybe the odd pipe, but not often.

Babygirl. X

Some may say naiev, some may say educated/realistic as you said.

I believe true harm reduction would allow a person to obtain whatever substance they required/wanted, just under some sort of regulation.

You only have to go back to about 1920 and nothing was illegal and society wasn't falling apart back then, the war on drugs has done far more harm than the drugs themselves ever would have had they been available to all who desired them, if they were provided alongside education/support services and those who did decide to avail themselves of said substances were not treated as second class or morally bankrupt, which of coarse created an us against them culture that has only grown stronger over time.

In my eyes the authorities saying, yes these substances exist but Joe public may not have access to them is nothing other than fascism.

 

[vision conquest]

cocaine and alcohol fella

It literally turns into a new drug in your belly

Gave this a good nudge today and can confirm it is definitely better than coke alone.


51 years old and still learning...keep your mindds open people.


nice

edit...So doing some research on cocaethylene and reading the wikipedia article, it indeed confirms the fact that consuming cocaine while there is ethanol in one's blood creates the compoound cocaethylene which lasts longer than cocaine alone and is indeed stronger, however I came across the little tid bit that said that cocaethylene has an 18-25 fold higher risk of sudden death than cocaine alone, to which my wife replied....I wouldn't mind dying if I was toasted....can anyone argue with this logic.lol.

 

[Ex-Cracker]

Nope!!

 

[Ex-Cracker]

Some may say naiev, some may say educated/realistic as you said.

I believe true harm reduction would allow a person to obtain whatever substance they required/wanted, just under some sort of regulation.

You only have to go back to about 1920 and nothing was illegal and society wasn't falling apart back then, the war on drugs has done far more harm than the drugs themselves ever would have had they been available to all who desired them, if they were provided alongside education/support services and those who did decide to avail themselves of said substances were not treated as second class or morally bankrupt, which of coarse created an us against them culture that has only grown stronger over time.

In my eyes the authorities saying, yes these substances exist but Joe public may not have access to them is nothing other than fascism.

Agreed! The jack boot of so called authority stamping on those in medical need, or just chilling!

 

[GulpingBatteryLiquid]

2cb and ketamine. That combo has taken me deeper than any other psychedelic has managed on its own.

One time I did this combo and thought that the Spandau Ballet music video ("True", I believe) was communicating with me

 

[GulpingBatteryLiquid]

i hear everyone say this, but from what i under stand it's more toxic. not sure if i'm wording that correct scientifically... like a ton of stuff will turn toxic when taken enough, but i hear it's not the healthiest combo.... to each their own though.

Yeah it's way worse for your heart than cocaine / alcohol taken alone

But a lot of things mentioned in this thread aren't exactly as healthy as an organic salad either

 

[Electrum1]

Cigarettes and coffee

 

[Deleted member 585202]

Schmoke and a pancake

 

[izo]

I don’t know which one is the best one as there Are certainly a few, here are some:

Opioid + tryptamine/lydergamides: a lovely calm and Trippy feeling, always liked it. The only opioid that doesnt work so good for this is Kratom.

Dissotives + opioid: had this one once only, great. I had a solid dose of dck and then some 2-methyl-ap237 on top. This is a very lacklustre opioid on its own but with a disso it was enough to provide a great relaxed state for hous. Really blissful.

Alpha pyrrolidino ketones (a-pvp, a-php and the like) along with some benzo in a bubble + ghb: really relaxed feeling.

Dissociatives + serotonergic halucinogenes: always a great high and a lowered chance for a Bad Trip.

 

[Nightwalker973]

While I don't recommend mixing these together without prior experience with one of the two substances, mixing a heavy meth binge with a dose of acid is in a class by itself. First time I tried LSD I was on day three and the experience was life altering.

 

[Esperighanto]

While I don't recommend mixing these together without prior experience with one of the two substances, mixing a heavy meth binge with a dose of acid is in a class by itself. First time I tried LSD I was on day three and the experience was life altering.

I wouldn't call my experience with it a 'heavy' meth binge, but I was housing some methy fake Addies at one point before taking a truly enormous dose of LSD (on the street, I'd guess 25-30 tabs). It was beuatiful man, since then meth and ritalin/4F-MPH have competed as my favorite stimulant to mix with LSD. As far as sedatives, etizolam, soma, gabapentin, 7-OH-mitragynine and tianeptine all shined for me, personally.

Dissotives + opioid: had this one once only, great. I had a solid dose of dck and then some 2-methyl-ap237 on top. This is a very lacklustre opioid on its own but with a disso it was enough to provide a great relaxed state for hous. Really blissful.

I'm always curious to ask people who have experience with RC opioids from this era, some time between 2014-2017 or so, I stumbled upon an unidentified RC opioid that lasted maybe 18-30 hours total, I ate maybe 4-5 pressies assuming it was oxycodone. It felt more sedative, but not quite as sedative as heroin, more similar to dilaudid than oxycodone if that makes sense. It lasted SO MUCH longer than anything we'd ever seen on the street, I assumed that worst case if it was some mystery RC it'd have worn off within a day or less, but it lasted closer to a day and a half or two days iirc. This was around a decade ago, sorry I can't provide more details, but does this long timeframe remind you of anything you ran into?

 

[RobustTuna]

Speedballs

 

[Psynaught]

Soma, THC, Oxy, Ambien, Alcohol. Weirdest shit ever but its lowkey insane. U have a high chance of respiratory depression tho so be careful, honestly don't recommend it unless u have a tolerance or some experience.

I have a script for Ambien, it doesn't get me high at all, just helps w/ sleep. I used to love alcohol but could not stop at 1...or 5 drinks so I gave it up 33 years ago (went to AA for 18 years). I never understood Oxy...only took it as prescribed after surgeries until finally I got 30 mg caps containing powder (designed by a shady pharmacy) to hit you all at once. I took 2...then one more 45 minutes later and OMG, that high was incredible. I understand why it is so addicting which is why hardly ever take them.

Arguably the most euphoriating drug ever was smokable ice. This was 30 years ago and I got the purest of stuff and that high was unbelievable. I always liked benzos.

Never really combined 2 drugs together although technically when I was drinking I did coke, speed, and pot a bunch. I also have Somas but only take them maybe once a month after a really brutal back or leg workout.

 

[Psynaught]

MXE + MDMA

also

IV hydromorphone + oral soma

I used to get both Oxy (real) and Soma from a guy who combined the 2 and yeah, pretty amazing. However this guy has fallen off the planet....tried to find him everywhere. He is either dead or in jail, sadly.

Good for me because it keeps me terrified of an opiod addiction.

 

[Psynaught]

I'm just teasing try not to take the South Park meme too literally. I'm sure you're a lovely person

I can't say I'm a fan of the Nancy Reagan approach to harm reduction though (don't do drugs, just say no, etc) considering all the good it did in the 80s and 90s but you're quite right that the only way to completely mitigate the risks of using a drug is to simply not use it. That's harm reduction 101.

Of course, just because you tell someone not to dabble doesn't mean they're going to listen which is why making clear and unbiased drug information available to everyone is so important. It's funny you you should mention water, the untimely fate of Leah Betts in the mid-90s is a great example of how promoting abstinence over safe (as possible) use simply does not work and can paradoxically lead to further harm.

Anyway, all intended in good spirits friend.

Excellent point. What needs to be done is to explain the complexity of it and the progression. When young I was given the Nancy Reagan line which involved no thought. At 12/13 I smoked a little pot, nothing bad happened and I thought that adults were just liars.

12 yeas later I was a full blown alcoholic and abuser of drugs. At 14 we caught my son vaping (and he was taking other things). I sat him down and explained how insidious drugs could be. For example, once I started getting high every day (age 13) I stopped maturing and learning how to solve problems without drugs. So at 30 I still was mentally a teenager. I was diagnosed as bipolar later in life and I know 100% that it was caused by all the meth/ice I smoked in my early 30's.

So I explained step by step to my son how drugs could destroy his life. Took him to AA/NA meetings (were he was totally freaked out by this womans' story and how she used to glue her crack pipe to her hand so she wouldn't lose it). We drug tested him for a while and he is 18 and has not touched anything in years. He is off to college (where I am sure he will drink). However he has gone through his formative years, matured, without being held back by drugs.