AFAIK Coke binds to SERT kicking off the MDMA and quickly altering the way it affects you.For me, dextroamphetamine taken with MDMA tends to be heavily dex-amp-driven and it fucks up what would've otherwise been a perfect roll. The same is true of cocaine. Just wait until after the rolls and psychedelics are over. I think it has to do with their serotonergic activity interfering with MDMA's unique action.
Yep, that matches consistent experience and was very well recognised and understood.AFAIK Coke binds to SERT kicking off the MDMA and quickly altering the way it affects you.
I'm really not qualified like everybody else here to answer on the black but I never once saw or heard about anything remotely resembling that MDMA wise until 2005 and no experience or knowledge of the scene since.What you think about this photo ? link
One is black MDMA and the other is champagne.
The champagne has no to extremely little smell while the black actually has a nice classic MDMA smell.
Black has been energy control tested at 87% pure, other is unknown but off a good source.
The black has definately a hint of blue in it, would this be dye or something else coating it ?
Looking forward to eating it. - will probably try the black first
Thanks !
Honestly i'd feel the same way, if not for the fact it's been tested by a lab.I'm really not qualified like everybody else here to answer on the black but I never once saw or heard about anything remotely resembling that MDMA wise until 2005 and no experience or knowledge of the scene since.
I'm not saying I have reason to believe it's not legit.
Just very alien to me. Interesting though.
It looks, like charcoal.Honestly i'd feel the same way, if not for the fact it's been tested by a lab.
I'll test using my own kits beforehand just to make sure, there is numerous things on reddit regarding black MDMA. I've even got bright orange before and all tested fine and sent to lab with flying colors.
I believe it might be a branding, as it comes off onto the hands when feeling.
Any particular reason for avoiding fused crystals? Also any knowledge you can drop on us about what kind of crystals to look out for, or that you do in particular?
Any particular reason for avoiding fused crystals? Also any knowledge you can drop on us about what kind of crystals to look out for, or that you do in particular?
No, I think you’re just speculating. Cocaine acts as a potent reuptake inhibitor of dopamine, adrenaline, and serotonin. And as we all know, serotonin reuptake inhibitors will blockade the serotonin transporter, making it unavailable to MDMA and the roll never happens. Not to mention, I know from multiple personal experiences that this is the case. Even dead of the middle of rolling your nuts off, do a couple lines of cocaine and you’ll see immediately what I mean, although don’t be mad at me when you ruin your roll for the evening in this manner. ¯\_(ツ)_/¯AFAIK Coke binds to SERT kicking off the MDMA and quickly altering the way it affects you.
I meant the former, yes.No, I think you’re just speculating. Cocaine acts as a potent reuptake inhibitor of dopamine, adrenaline, and serotonin. And as we all know, serotonin reuptake inhibitors will blockade the serotonin transporter, making it unavailable to MDMA and the roll never happens. Not to mention, I know from multiple personal experiences that this is the case. Even dead of the middle of rolling your nuts off, do a couple lines of cocaine and you’ll see immediately what I mean, although don’t be mad at me when you ruin your roll for the evening in this manner. ¯\_(ツ)_/¯
EDIT: Oh, by “kicking off” did you mean competitively bind to the site? Or did you mean it like kick off the effects? Because it’s definitely the former, not the latter…
Right so cocaine works as triple reuptake inhibitor, while MDMA works mostly as a triple monoamine releaser, but also exhibits modest reuptake inhibition effects as well (which is why redosing MDMA more than once is mostly ineffective, causing more neurotoxicity and less desirable effects each time… You wanna roll hard? Take a big dose all at once). [EDIT: to clarify, 5-HT reuptake inhibition does not cause neurotoxicity; MDMA use does, but given that there is a diminishing return of desirable effects while the neurotoxicity still occurs, it's simply not worth chasing the high. /END EDIT] MDMA works by traveling up the serotonin transporter to the presynaptic storage of 5-HT where it binds, opening the calcium ion gate and precipitating a flood of serotonin.I meant the former, yes.
My choice of words was excessively informal and therefore unclear.
Cocaine has a higher binding affinity for SERT than MDMA, right?
Right so cocaine works as triple reuptake inhibitor, while MDMA works mostly as a triple monoamine releaser, but also exhibits modest reuptake inhibition effects as well (which is why redosing MDMA more than once is mostly ineffective, causing more neurotoxicity and less desirable effects each time… You wanna roll hard? Take a big dose all at once). MDMA works by traveling up the serotonin transporter to the presynaptic storage of 5-HT where it binds, opening the calcium ion gate and precipitating a flood of serotonin.
So if a compound binds to the transporter to act as a reuptake inhibitor, it’s as if your brain hired some extra bouncers for the opening of its new night club called Synapse. Normally MDMA knows the doorman at club Synapse, so to speak, and is all like: “Listen, we don’t pay admission and the bouncers don’t check us, and we… walk around the metal detectahs…” But with the added bouncers at Synapse courtesy of “El Llello Magnífico Staffing, LLC” (or “SSRI Security Solutions, Inc.”) it also has the effect of blocking MDMA from getting into Synapse. She’s no Lil Kim, tonight. Back of the line just like everybody else.
I just avoid overlapping peaks of the drugs, and they both work fine. Give them some space, I guess, but it's not that serious. Just, when you're peaking on MDMA, don't go blowing lines thinking it will only make things better, bc it won't. And wait until after the roll to take SSRIs as a harm reduction technique.Me too. If I do anything like meth or crack before I roll, it totally fucks it up.
Do you know how long to wait before rolling after taking a stim?
Easy there, killer. I didn't say 5-HT inhibition causes neurotoxicity and am aware of the use of SSRIs post-roll, as harm reduction. I was saying the neurotoxicity of it would still occur minus the desired effects. The toxicity comes about on account of alpha-methyl-dopamine formation that occurs when MDMA's 3,4-methylenedioxy ring is demethylated and broken apart to form the neurotoxic catechol, 3,4-dihydroxy-alpha-methyl-phenethylamine. I appreciate your efforts to clarify things all the same, thoughActually the neurotoxicity of MDMA from subsequent redoses is due to the altered metabolism after that first dose not it’s reuptake inhibiting abilities.