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☮ Social ☮ PD Social Talk Thread: If 2020 Was the Dumpster, Can 2021 Be the Fire?

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AutoTripper said:
But @Perforated you are infinitely more schooled on drugs than I, research and pharmacology wise.

I’m brainstorming here. LSD- we think needs to meet the 5hta receptor sites in gut and brain right?

That lock and key. How LSD turns on the engine,

Where do the nerves come into this? Indirectly acted upon by the brain?

Because I’m thinking about why plugging would be so different and more mindblowing.

I mused- maybe a greater percentage of the LSD gets directly into the nerves, via back door?

But that wouldn’t fit right? (Lol, no pun there, it was tight lol).

So maybe….the LSD is more efficiently, directly delivered to the receptor sites, by travelling directly through the nervous system, vs orally more steps and metabolic processes before entering the nerves, the transport system.

Does that potentially hold any tract?
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Hey @AutoTripper. I think you greatly overstate my drug knowledge. Apart from the effects of meth I’m no expert on anything and mostly rely on googling scientific papers to answer questions about anything besides amps (don’t tell anyone, it’s kind of an embarrassing secret).

However, from what I have read there is little enough known about the metabolisation of LSD-25 taken orally let alone taken anally. In fact I cannot recall ever reading anything ever that discussed plugging LSD - either as an anecdote or in scientific research. So you may be breaking some new ground here. What is generally cited in the literature is that orally ingested LSD-25 has a bioavailability of around 70 % and reaches a peak plasma concentration in between 40-130 minutes. That said, plasma concentrations are not thought to correlate to intensity of effects. It’s primary mechanism of action is activation of 5HTP2A receptors in parts of the cerebral cortex. Furthermore, it’s bioavailability and plasma concentration are greatly influenced by first pass metabolism including things such as Ph in the stomach and duodenum and the gastric evacuation rate. Generally only 1 % of LSD-25 is unmetablolised and excreted unchanged.

All the studies researching this seem to have the patient swallow the LSD immediately rather than let the blotter sit under their tongue for some period of time which I think is more common practice amongst recreational users. I’d assume sub-lingual administration reduces first pass metabolisation somewhat, but it has not been researched really.

In oral administration, metabolisation occurs primarily in the liver and LSD_25 is quite quickly converted into numerous non-psycho-active metabolites all with a longer half-life than LSD-25 itself. LSD undergoes N-demethylation, N- deethylation, aromatic hydroxylation, and oxidation depending on the animal species. At least 3-different enzyme systems are involved and the cytochrome P450 seems to the most important. Recent research suggests there may be psychoactive metabolites produced also and that many psychedelic effects are caused by downstream effects of activation of 5-HTP2A (for example serotonin receptors can cause or influence effects in the dopamine system even when a drug does not directly act on dopamine)

Drugs taken rectally may or may not initially bypass the hepatic system depending mainly on how far you shove them in. There is a dividing line in there called the pectinate line. Above that veins drain into the portal veinous system which transports drugs to the liver where they will start to be metabolised before reaching the brain and having psychoactive effects. Below that line the more likely they are to be absorbed by the systemic venous system which will circulate them via the femoral vein to the brain in the first pass.

Bottom line (no pun intended) is that your dose was rapidly absorbed hitting a high plasma concentration way faster normal with far more unmetabolised LSD-25 hitting your brain at once and in very short period. Recent studies have shown that then LSD-25 hits 5HTP2A receptors it basically enters them and closes a kind of lid over the top of itself accounting for the duration and intensity of trips. It cannot be dislodged and become metabolised for hours after it hits the receptors. So basically you got a massive unmediated dose that dug in for the duration across many more receptors than would normally be the case and were ultimately metabolised at a far slower rate than normal.

It is well known amongst pluggers of all drugs that a rectal dose should be somewhat smaller than an oral dose and not much bigger than what you you’ll consider safe for a straight IV dose. You just overdid it.
 
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Perforated said:
Hey @AutoTripper. I think you greatly overstate my drug knowledge. Apart from the effects of meth I’m no expert on anything and mostly rely on googling scientific papers to answer questions about anything besides amps (don’t tell anyone, it’s kind of an embarrassing secret).

However, from what I have read there is little enough known about the metabolisation of LSD-25 taken orally let alone taken anally. In fact I cannot recall ever reading anything ever that discussed plugging LSD - either as an anecdote or in scientific research. So you may be breaking some new ground here. What is generally cited in the literature is that orally ingested LSD-25 has a bioavailability of around 70 % and reaches a peak plasma concentration in between 40-130 minutes. That said, plasma concentrations are not thought to correlate to intensity of effects. It’s primary mechanism of action is activation of 5HTP2A receptors in parts of the cerebral cortex. Furthermore, it’s bioavailability and plasma concentration are greatly influenced by first pass metabolism including things such as Ph in the stomach and duodenum and the gastric evacuation rate. Generally only 1 % of LSD-25 is unmetablolised and excreted unchanged.

All the studies researching this seem to have the patient swallow the LSD immediately rather than let the blotter sit under their tongue for some period of time which I think is more common practice amongst recreational users. I’d assume sub-lingual administration reduces first pass metabolisation somewhat, but it has not been researched really.

In oral administration, metabolisation occurs primarily in the liver and LSD_25 is quite quickly converted into numerous non-psycho-active metabolites all with a longer half-life than LSD-25 itself. LSD undergoes N-demethylation, N- deethylation, aromatic hydroxylation, and oxidation depending on the animal species. At least 3-different enzyme systems are involved and the cytochrome P450 seems to the most important. Recent research suggests there may be psychoactive metabolites produced also and that many psychedelic effects are caused by downstream effects of activation of 5-HTP2A (for example serotonin receptors can cause or influence effects in the dopamine system even when a drug does not directly act on dopamine)

Drugs taken rectally may or may not initially bypass the hepatic system depending mainly on how far you shove them in. There is a dividing line in there called the pectinate line. Above that veins drain into the portal veinous system which transports drugs to the liver where they will start to be metabolised before reaching the brain and having psychoactive effects. Below that line the more likely they are to be absorbed by the systemic venous system which will circulate them via the femoral vein to the brain in the first pass.

Bottom line (no pun intended) is that your dose was rapidly absorbed hitting a high plasma concentration way faster normal with far more unmetabolised LSD-25 hitting your brain at once and in very short period. Recent studies have shown that then LSD-25 hits 5HTP2A receptors it basically enters them and closes a kind of lid over the top of itself accounting for the duration and intensity of trips. It cannot be dislodged and become metabolised for hours after it hits the receptors. So basically you got a massive unmediated dose that dug in for the duration across many more receptors than would normally be the case and were ultimately metabolised at a far slower rate than normal.

It is well known amongst pluggers of all drugs that a rectal dose should be somewhat smaller than an oral dose and not much bigger than what you you’ll consider safe for a straight IV dose. You just overdid it.
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You know, the way you put that so elequently, I'm suddenly proud of myself, realising what I achieved getting the Acid into my system so fast and locked in like you say.

In the cannabis world, is the concept of "Vape signature."

I've used a wide array of different cannabis vaporizers. It's funny how different vaporizers, using the same weed, can be as different an experience as different strains of weed, or even more so,

From the imagery you've given me above, the locking in determining the trip ride, peak, intensity, every time you take Acid, the exact trip would be unique according to the exact seal, and all other factors.

So I'm calling it the Trip signature.

If it's just overstimulation of nerves vs damage, I'll have no regrets. But no way would I dose that much again.

I don't feel that way about an oral mg. I'm not hurrying to trip again though, not because I'm haunted from it or afraid of the in trip experience.

@Perforated Big thanks man for that great way of presenting that insight above. You're very modest. You do very well to be realistic, open and as informed as possible on things.
 
Had a really good time on intranasal Methcathinone yesterday. It‘s similar to an amphetamine high although way shorter-lasting and a little more fiendish. I was very talkative and euphoric which reminded me of cocaine a little, but it doesn’t really alter your personality and turn you in an overly confident douche. IMO it shares similarities with amphetamine, 3-MMC and cocaine. 8/10 would recommend trying out, if you have access to high quality stuff.

Edit:
The only negatives were the short, active duration but the comparatively long residual effects. Also my heart-rate was quite high, even during sleep afterwards. My sleep was everything but restful, lol. But I don‘t think that‘s surprising after snorting lines of a cathinone.
 
I'm dedicating this tune to myself for the moment lol. It's an old one I like already.


You know, I am not at all affeared of tripping again. Like, the onset, comeup, peak etc, no anxiety about that, if I trip on Acid again.

If anything, I'm more chilled about it than ever. Because that was so intense physically, my nerves and muscles spasmed on it, but my mind was never worried or working for control, only after the bizzare heavy crash Tuesday morning, and feeling literally damaged this week, fortunately seems to be passing.
 
Psychestim said:
Had a really good time on intranasal Methcathinone yesterday. It‘s similar to an amphetamine high although way shorter-lasting and a little more fiendish. I was very talkative and euphoric which reminded me of cocaine a little, but it doesn’t really alter your personality and turn you in an overly confident douche. IMO it shares similarities with amphetamine, 3-MMC and cocaine. 8/10 would recommend trying out, if you have access to high quality stuff.

Edit:
The only negatives were the short, active duration but the comparatively long residual effects. Also my heart-rate was quite high, even during sleep afterwards. My sleep was everything but restful, lol. But I don‘t think that‘s surprising after snorting lines of a cathinone.
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Did you synth it yourself or source it via a third party? Just curious. I've thought about trying to make some methcathinone a few times over the years but never had a good space to do it. Now I live in a house and I'm thinking about trying out a few experiments I've been putting off.
 
Cream Gravy? said:
Did you synth it yourself or source it via a third party? Just curious. I've thought about trying to make some methcathinone a few times over the years but never had a good space to do it. Now I live in a house and I'm thinking about trying out a few experiments I've been putting off.
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A chemist friend of mine made it, alongside ethcathinone, alpha-PPP, methamphetamine, etilamphetamine and a few others.
 
Was going to trip today but don't know now not really in the right mood maybe tomorrow def will want to dose early if I do since t4 lasts a while. Used to say fuck it and dose anyway even when I wasn't in the right mood but don't like doing that anymore. Only got like 400mgs or so of some distillate left from what's left of a few different types and little spec of shatter; going to try and stretch it out as long as possible. Always get real wasteful and screw up my tolerance when I first get an order.
 
Well I'm on abilify 400 mg a month and i think these blotters must have been around 200 micrograms (i found them on the inet and ir said 220). Because 2 of them gave a very decent trip with visuals and general lsd hilarity.

So I'm thinking i need like 1,5 to 2 times what i would normally take.
 
Quick question from a neophyte. I realize to be need more self sufficient I need to purhase some things outside my comfort zone. Meaning possible domestic RC's. I need to learn the skill. Clearnet stuff, not venturing into any darker areas.

The question is I see places only accepting bitcoin thru the cash app. Is that something I should learn through a video and set that up? I mean I won't use it much so I just want to be able to pay for some things and this is the suggested way. Yay? Nay? Is that the wrong path? It seems bitcoin through the cash app is one of the most popular ways. Some places can't even do a bank transfer so I was thinking this is something I should learn.

I have no knowledge of stocks or how any of that works . I was the true hippy kid of the family. But I am thinking bitcoin could be easier. I hope this did not break any rules just looking for a yay or nay on the process. I got absolutely no friends that adeventure through this so I am stuck with video's and trial and error on my own.
 
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Bitcoin is super easy to buy, especially through Cash App. Download the app, hook up your bank account. You can buy crypto instantly and also send it to any address. So simple. But yeah if you can find videos on it, watch them just to make sure you're doing it right. I've been working with crypto for years now so of course it seeks easy to me.
 
Perfect thanks for the encouragement Xorkoth. Exactly what I needed. I have a few videos started setting it up about 9 months ago and left it as one place said they woudl take Zelle. But I reall want to set this up and be ready to take care of my own destiny. :)

Ok then, let the learning begin!....
 
So Ive got 7 days off booze.
Last week at the start of this run I decided Id pick up some more Tiletamine.
Despite binging on it the last two times.

IN dissos seem to be addictive for me.
Gonna try and stick to IR.
Havent used IR as an ROA before. So gonna proceed slowly
 
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