I think so, too.I can't speak for everyone, but from my perspective, we are trying to do more here than just identify who has made quality pills. We want to know WHY some batches of MDMA produce different, sub-par effects. We want some type of knowledge that can benefit the whole community, so that a test could be produced, or someone like Drugs Data can adjust their approach to differentiate quality from inferior product.
Exactly!The NMR may seem like spinning wheels to you, but analytical data is one of the only things that is actually going to push this conversation towards a concrete answer.
Can you divulge the weight of your girlfriend, too ?I don't have an exact weight, but it was around 150-200 mg.
Yeah, exactly. Unless you are eating your dose as one 120 mg rock, this is not going to be a factor. Polymorphism is important for pharmaceuticals with poor solubility and complex formulations, but with MDMA hydrochloride powder in a gel cap, the gel cap is going to be the bottleneck for dissolution.
It seems that anhydrous MDMA hydrochloride only appears as one polymorph.
Having the hydrate, however, will have a small effect on the drug's action, as hydration will reduce the effective mass of the active component. MDMA hydrochloride is known to come in several hydration levels:
The quarter-hydrate will be 98% of the potency of the anhydrous compound; hemihydrate, 96%; three-quarter-hydrate, 94%; and monohydrate, 93%.
Surface area effects dissolution and bioavailability..Curious, would actually taking the dose as one 120mg rock potentially have a significant effect for whatever reason? Ever since I had that mehDMA experience in 2018, i make sure to grind it to a fine powder almost out of superstition as the MehDMA i'm certain we didn't crush up, and I always wondered if that would impact digestion of it (I got a gnarly stomach ache as well)
I've only taken MDMA 3 times since then (all the white scentless quartz crystal stuff), no problems any of the times, full magical experience with not a hint of doubt about it in my mind.
I rolled this weekend with it and remembered something else, between 2015-2018 every time I rolled with 100mg clean MDMA, during the come-up/pre-peak I would get these insane pins and needles in my extremities for 10-15 minutes. It wasn't necessarily painful, but it sure scared the shit out of me without fail each time it happened. I've posted threads about it on here before, couldn't find much info on similar experiences. It actually became a huge source of come-up anxiety, I just had to sorta trust that it would fine, and medical at the festival didn't seem to think it was all that alarming. But, these last 3 rolls, not a sign of that symptom, nor did I have it the time in 2017 that was maybe the hardest I ever rolled (also with fine powder quartz scentless). This could be totally unrelated, maybe just a symptom of my biology during those years?
Anywho, all 5 of us took 100mg, my girlfriend only took 80mg by choice, went to a rave and it was the most therapeutic experience I've had since the last time i took it. My other friend took 100mg and ended up puking, she ate a ton of fruit right before thinking that was a good idea (I'm not sure it is?) and has got to weigh no more than 115lb...
(Off-topic but DMT vape pen is amazing in the after hours of the roll, the MDMA after effects filter out any negative bodyload/mindset you could have from DMT since you're already so at peace. Definitely recommend, lots of small hits... DO NOT DO THIS WITH CHANGA, IT WILL GIVE YOU SEROTONIN SYNDROME OR SOMETHING).
Me thinks, that complete dissolution is more effective than crushing in equalizing all bioavailability issues due to crystalline polymorphisms.Always crush it into a fine powder for max results.
Well, could that be a potential theory
Yes, as I said a few pages back I tried plugging and injecting MehDMA and it did not change the nature of the effects and only made it stronger MehDMA unfortunately.Right, probably not the culprit, but might be worth it for anyone here to always crush it to a fine powder for peace of mind. As vash posted, its clearly documented that it has some relation to bioavailability, might as well eliminate it. Not anything more than a layman'd observation, but the MehDMA always feels on my body like its not absorbing right, hard to explain. Like a stalled car engine, dud firework, blew a fuse, etc...
Psy has anyone here even tried plugging MehDMA to see if it makes a difference? I've never tried plugging anything, I'm such a lightweight when it comes to drugs I'm always scared I'd get way too fucked and shit myself at the rave
On another note, a friend of mine took MDMA for the first time in a while a couple weeks ago, the magic stuff we all have. She swore off MDMA a while ago as it makes her feel awful the next day/week, tons of stomach issues while on it, never feels worth it for her. She took 100mg of this stuff and had the same problem, she's back to swearing it off forever. She never had a period of abuse with it, always took responsible doses, didn't mix with other drugs, and didn't redose (much) to my knowledge. I'm always incredulous of this, as for every single other person 100mg of it has them on the moon and no issues. Was talking to her about it this weekend, just reminded me that these things affect everyone differently and that will always play a role as a variable in our research, good to mindful of it.
PS: this was the first time I took MDMA without some varying dose of LSD in a very long time, years. While it was still magical, the comeup was a whole lot less paranoid/stressful/intense and the absolute energy explosion that is a candyflip peak was absent, but it wasn't as if it was disappointing or anything was missing for that reason, it was just different. Still felt fully satisfied by it.
Yes, as I said a few pages back I tried plugging and injecting MehDMA and it did not change the nature of the effects and only made it stronger MehDMA unfortunately.
On another note, a friend of mine took MDMA for the first time in a while a couple weeks ago, the magic stuff we all have. She swore off MDMA a while ago as it makes her feel awful the next day/week, tons of stomach issues while on it, never feels worth it for her. She took 100mg of this stuff and had the same problem, she's back to swearing it off forever. She never had a period of abuse with it, always took responsible doses, didn't mix with other drugs, and didn't redose (much) to my knowledge. I'm always incredulous of this, as for every single other person 100mg of it has them on the moon and no issues. Was talking to her about it this weekend, just reminded me that these things affect everyone differently and that will always play a role as a variable in our research, good to mindful of it.
I had a friend like this too. It did not matter what the product was. Everyone else at the party would be having a great time, and she would be WAY TOO FUCKED UP. She would shake and just be gone...in an uncomfortable way. There was clearly some underlying genetic/personal issue at play. She responded really strongly to LSD as well.
And, I also recall people who had abused MDMA (multiple times per week for months), and just lost the ability to roll.
There are clearly a lot of factors.
But, I still think that when a lot of people are reporting the same effects from one particular batch of MDMA, then the issue is likely the product. Especially when those people have a wide variety of past usage histories including limited/no use.
It all makes me wonder if for some people who think they have this issue, issue of MehDMA, and have tried MANY different batches for few years and still can't roll, maybe the MDMA has started to simply stop working regardless of the quality of product they have is. Its equally if not more plausible in that scenario.