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What is wrong with the MDMA available today?

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What conclusions so far?
Inpurities makes mdma work weaker or do we go to the theory that inpurities make mdma magic?
 
I haven't looked at this thread in a year and am just not interested enough to catch up on it anymore by reading it, since i can never do MDMA again and haven't for 3 years. Its it still just a big circle jerk of scientific theories and e-heads comparing subjective mdma experiences, or has any real science performed yet to get closer to the answer? Thanks.
 
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I haven't looked at this thread in a year and am just not interested enough to catch up on it anymore by reading it, since i can never do MDMA again and haven't for 3 years. Its it still just big circle jerk of scientific theories and e-heads comparing subjective mdma experiences, or has any real science performed yet to get closer to the answer? Thanks.
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If you must get it simplified for you: NMR analysis has been performed on multiple inadequate"meh" samples and one magic sample. NMR analysis showed that the meh samples had an additional peak on NMR analysis. Cleaning one of these samples with a silica column resulted in the removal of the additional peak. The contaminant that was separated is going to be analyzed, and the cleaned product will be tested. All courtesy of @vash445

These NMR results seem to correlate with published research data that shows that certain production methods result in impurities that can block the effects of MDMA. (https://sci-hub.tw/https://doi.org/10.1124/jpet.105.084426)

The current theory, supported by NMR data and previously published research, is that there is a contaminant that is interfering in the full effects of MDMA. Traditional GCMS testing seems to be blind to the contaminant.

So, overall, seems like the circle jerking e-heads are doing pretty well over here, thanks for asking.
 
Thanks for the summary because i wasn't going to read through that last 100 pages of people talking about their bomb mdma from the 2000s to find the information you gave me.

you say the meh samples had "an" additional peak. was this CNMR or HHNMR? All the byproducts in that paper would result in more than "one" additional peak. did they do any 2D NMR to determine if that additional peak is actually connecteced to anything MDMA-like?
 
My summary was the super simple version. There were other variations on NMR, but the meh samples shared anomalies in 3.5 - 3.7ppm. If you want to know more, most of this info is recent in the thread (including links to the NMR graphs themselves). Vash just posted the first NMR result back in November. Specific questions re: methodology would be better answered by @vash445 or @vecktor (who has been analyzing the NMR results). Vash previously indicated he ran NMR 1H and 13C along with MALDI. There are other tests in the works right now, so we are in a holding pattern while we wait for other info.

Here is one of the meh results: https://www.bluelight.org/xf/thread...the-mdma-available-today.791073/post-14725832
Also, check this comment from @ThreePointCircle https://www.bluelight.org/xf/thread...the-mdma-available-today.791073/post-14726147

@vash445 Could you do a summary post with links to all the NMR results?

Also, no offense, but eheads talking about bomb MDMA from back in the day is what spawned and pushed this conversation to the point it is at. I get that you don't want to dig through the thread, but we are where we are because people were observant and analytical about variations they were noticing.
 
indigoaura said:
My summary was the super simple version. There were other variations on NMR, but the meh samples shared anomalies in 3.5 - 3.7ppm. If you want to know more, most of this info is recent in the thread (including links to the NMR graphs themselves). Vash just posted the first NMR result back in November. Specific questions re: methodology would be better answered by @vash445 or @vecktor (who has been analyzing the NMR results). Vash previously indicated he ran NMR 1H and 13C along with MALDI. There are other tests in the works right now, so we are in a holding pattern while we wait for other info.

Here is one of the meh results: https://www.bluelight.org/xf/thread...the-mdma-available-today.791073/post-14725832
Also, check this comment from @ThreePointCircle https://www.bluelight.org/xf/thread...the-mdma-available-today.791073/post-14726147

@vash445 Could you do a summary post with links to all the NMR results?

Also, no offense, but eheads talking about bomb MDMA from back in the day is what spawned and pushed this conversation to the point it is at. I get that you don't want to dig through the thread, but we are where we are because people were observant and analytical about variations they were noticing.
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assuming that HNMR was taken in CDCl3 and the chemical shift properly aligned; the giant peak at 3.8 looks like dimethylcarbonate (it looks like a singlet but hard to tell in that image). Not hard to imagine dimethylcarbonate forming from CO2 and methanol during synthesis. Also it wouldn't come off super easily under vaccuum. Did the CNMR spectra of the same sample show peaks at 156 and 55?
 
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LucidSDreamr said:
Did the CNMR spectra of the same sample show peaks at 156 and 55?
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Not as far as I can tell. Basically, on the magic sample there was a big peak at approx 45. On the meh sample that got cleaned, there was a big peak at 40 pre-cleaning, which moved to 45 post-cleaning.

On all three there was a little peak at approx 56, but it didn't really stand out from the crowd. And nothing at 156.
 
ThreePointCircle said:
Not as far as I can tell. Basically, on the magic sample there was a big peak at approx 45. On the meh sample that got cleaned, there was a big peak at 40 pre-cleaning, which moved to 45 post-cleaning.

On all three there was a little peak at approx 56, but it didn't really stand out from the crowd. And nothing at 156.
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not sure what it could be if it only has 1 carbon peak and one hydrogen peak, which is what seems to be the case. Something small and with symmetry. I don't think its it based on the chemical shifts, but think along the lines of trimethylamine oxide as a starting point for hypothesis of what it could be
 
@vash445 Is there any way to get Drugs Data some of the sample of mehDMA that you cleaned? They are very interested in reviewing it.

If you have a sample that you think has two substances in it that you
can clean out to get clean MDMA, can we get a fully homogenized 10-20mg
of the material to look at?

You said that someone saw only MDMA in a GC/MS analysis of the sample:
"These sub-par samples looked like MDMA on GCMS before he ran the NMR"

but how good are they at GC? Are they certain they couldn't see
anything in GC? Did they try multiple solvents, pressures, and
temperatures?

If there's no way to see the "other chemical" using GC, then our lab
can't help. But that would be some unknown compound that inhibits liver
or inhibits neuronal activity. It would, of course, be very interesting
if it were possible to actually demonstrate its existence.

So, if there's some of that available, we'd love to see any output and
some fully homogenized (so we don't get a sample that doesn't contain
any of the unknown compound). 10-20mg would be great.

earth
Click to expand...

 
LucidSDreamr said:
not sure what it could be if it only has 1 carbon peak and one hydrogen peak, which is what seems to be the case. Something small and with symmetry. I don't think its it based on the chemical shifts, but think along the lines of trimethylamine oxide as a starting point for hypothesis of what it could be
Click to expand...

The file ending ...207.pdf is confirmed magic, and the file ending ...579.pdf is confirmed meh.


On page 37 onwards there are reference 1H NMR plots.

The magic sample (...207.pdf) seems to match the reference MDMA HCL in D2O (page 45)
The meh sample ( ...579.pdf) appears be closest to MMDA base in CDCl3 (page 44). Not a super close match but I think its the best on my initial look
The other meh sample (...312.png) perhaps is also closest to MMDA but even less good a fit

So the big differences in the <7ppm range are: magic - peak around 4.87 (missing integration value?) that is not present in the meh sample. meh - big peak around 3.70 that is missing from the magic sample.
 

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LucidSDreamr said:
not sure what it could be if it only has 1 carbon peak and one hydrogen peak, which is what seems to be the case. Something small and with symmetry. I don't think its it based on the chemical shifts, but think along the lines of trimethylamine oxide as a starting point for hypothesis of what it could be
Click to expand...

first NMR batch "PRIVATE lab" USA made from safrole, Benz MEOH wacker with Al/Hg reduction. This batch was test on a MDMA/drug virgin who only prior drug use was garbage cocaine.

around here the topic gets juicy and the circle jerking where noone has a real clue;)

What is wrong with the MDMA available today?

www.bluelight.org www.bluelight.org

MDMA NMR with extended 13c on this private batch
 

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LucidSDreamr said:
not sure what it could be if it only has 1 carbon peak and one hydrogen peak, which is what seems to be the case. Something small and with symmetry. I don't think its it based on the chemical shifts, but think along the lines of trimethylamine oxide as a starting point for hypothesis of what it could be
Click to expand...

a 2D has not be ran. He was waiting for someone to ask for it I think he said. He felt COSY HMNR etc was better he said. Whatever IT is probably an amine because an acetone wash wont clean it. A wash was done on mine and many other batches

PS thank you for helping us and diving right in. We are still waiting for @vecktor report on magic and meh #2 but he is probably still busy
 
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