Nicomorphinist
Bluelighter
- Joined
- Apr 18, 2019
- Messages
- 1,401
It's probably possible, I'm thinking about ;
1. enkephaline and endorphine reuptake inhibitor.
I have definitely wondered about such things, and consider also that there has been sporadic evidence and theory over the years since the receptor theory was first promulgated that there may be a total number of opioid receptors on the order of anywhere from six to fifteen and each of these can have any number of subtypes, and the ζ opioid receptor found recently . . . any of the obscure opioid receptors could also be masquerading as something else, the reverse of the σ receptor which was until fairly recently thought of as an opioid receptor.
And then of course, as the case with the NMDA system, classical opioids and synthetics both have opioid-like effects
2. An enzyme inhibitor responsible for the breakdown of endogenous opioids.
There is that angle too, naturally . . .
3. And there's already Clonidine that actually help alot.
Yes, very much so
4. Alcohol ease it too.
It can help in a pinch to be sure, but there is the awful feeling of alcohol hangover on top of early-stage narcotic withdrawal, which is horrendous, as I am sure most narcotics people know already,
5. Stimulant like Amphetamine also work but it's not a everyone thing.
Quite a bit of evidence for that indeed, with the dopaminergic stimulants have the greatest effect. Which is why, for example, methylphenidate + tripelennamine + opioid(s) are combinations which has more impact than the ingredients themselves. Then there is lephetamine (Santenol) and so forth . . .
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