I've been abusing drugs for 7 years, 4 years daily and pretty heavily. (Ice, GHB, Xanax)and Then went into a rehab for 9 months, and was clean until relapsing 4 weeks ago on Heroin... When clean for the 9 months, my brain was seriously cooked, paranoid, and felt like I was starting my life again from Primary school. No confidence, no personality, not even knowing how to start a conversation.. The depression is horrible and you fight for the tinniest bit of energy but feel like all your bones are stinging. (this only picked up with the energy after 6-8 month) I've been told this it generally takes two years for the neuro pathways to level out, but not always (especially with meth).. Of course depending on the drug you use, or if you use a combination as well. The dopamine and serotonin levels in the brain are so FUCKED UP from all the chemicals, your poor brain doesn't no whats going on... If you keep using in those 2 years, and so many people do because of the depression they already feel, it will take even longer.. I'm a good case scenario. I know people that have serve paranoia and schizophrenia from using which is permanent.. HepC is a big one... but the worst is using once you have had clean time and you have no tolerance and have a shot, no long term damage, but could lead to death. Mixing Meth, GHB, Xanax and Heroin is seriously a heart attack waiting to happen, and everynight when I knock myself out to sleep, my heart beats so slow and I pray that I will wake tomorrow... Its fucking scary. But personally, Mental health for addicts is a nightmare) Yes, it states It usually takes two years for the nuro-pathways to level out the dopamine and serotonin in your brain, if your lucky and quit using at a reasonable age. I guess the long term damage that stays with you forever is the shit you have to do to get money and the situations you put yourself in and all the horrible things that go along with it.. If you are an addict you usually cannot stop using without rehab or NA so therefore numerous relapses can be very damaging long term.