The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

[xammy]

Whats the lowest dose you guys have been able to hole?

 

[Xorkoth]

I holed once, and it was on 40mg oral and then 20mg rectal 40 minutes in. I have a low dissociative tolerance (no acquired tolerance and a naturally low one).

I could be wrong but I was under the impression that it was a bad idea to mix amphetamines and MXE. I just assumed the DOX family was probably a bad idea with Mexy.

Wait for someone else to report in with more knowledge, but what is bad to mix with MXE is serotonin releasers. As far as I know, DOC does not release serotonin, it is simply an agonist. So my guess is it's fine. But like I said, I am not the most knowledgeable about this stuff so best to wait for someone who is to answer.

With regards to music & MXE, I find if I notice "imperfections" like in badly compressed files more. Also, either a nice, loud system with subs or a good pair of over the ear headphones makes a huge difference. Even my Cerwin-Vega E31O's (no sub) sounds kind of weak while the same tunes through my Audio Technica ATH M50's take me... there. Still like everything with MXE its somewhat unpredictable.

Over 3 years ok MXE use, I'm convinced the hole is only "open" sometimes. Sometimes taking more just won't get you there no matter what. It will get you confused & disoriented though. Lying still in bed with headphones & blindfold is is the best bet IME. Pure Bliss...

I agree, I use my nice headphones to listen to music in bed on MXE, it makes a huge difference. Also I thought it worth repeating that at low or medium doses I don't care for music on MXE, but for full-on doses, it's absolutely essential for me, it completely takes over the nature of the trip and I become the music, and the music leads me on a fantastic voyage through my mind and the cosmos.

 

[GolemGolem]

Has anyone mixed mxe with DOC? I don't believe it's listed on the safe /unsafe combo page.

I did once on weakish DOC trip, it was fine, nothing exceptionally good or bad to report other than the MXE being potenated a bit. If I was on a more satisfactory dose of DOC and had MXE I would likely be in the MXE, slowly at first.
I used to get the best M-Holes on the comedown of 4FA not sure how dangerous that was.

 

[Xorkoth]

Very dangerous, actually I took MXE on the comedown of 4-FA and had a very worrying and bad reaction, and also my MXE trip wasn't nearly as good as usual. The next day I was actually nearly as scared as I have ever been from drugs, I felt like I had been poisoned and might collapse. I was probably close to serotonin syndrome. I recommend no one ever combine MXE and 4-FA.

 

[Bone14]

Same with 3-MMC and MXE, I had a very very weird effect. Stay clear of stimulants on MXE.

 

[zzz101]

I took Ritalin on end of mXe one time, the Ritalin felt very clean. Though #$#$# stimulants! >.>

Music on dissociates;

mXe - incredible
DXM - incredible
Ketamine - music sounds awful, or there is no connection at all. My friend thinks the same, he thinks because ketamine effects the hearing level at certain frequencies??


there's a point you reach with mXe, where you take the drug, and yeah - music sounds great. then there's another level you reach; where music has never sounded this good, where music sounds better than when ur on mdma. Not only that, the music appreciation (and the drug) just feels more natural , if that makes sense? I mean, you can;t take mxe and expect to feel its true greatness, it takes a good mind-set, setting and dose(s) to get it.


for instance, you take a opiate or mdma and yea - you feel like ur got euphoric balls. You take mXe, and you don't notice how fucking euphoric it is, and when you do notice it, you feel that you haven't even taken a drug, you just feel incredible, like it is all natural. completely natural euphoria. (not forced, like mdma). That is what i love about mXe, And that is why i think it is a very set and setting-driven drug. (like alcohol or psychedelics are)

My friend(dude), and his friend(girl) 3 of us went out & hit some bars for a few drinks. Anyway, he was on MDMA,(he acts normal) she was on MDPV, and i was on mXe. The 3 of us got along so well with each other, its like the 3 drugs all synced together well haha. we were very social with other ppl too . Epic small night. And goes to show ppl like different things.

Anyway, everyone i know in real-life , i seem to be the only one who likes mXe, my mates will do it only if it is the last thing available. They just roll or drink. Is this the same for other ppl? It seems to be very popular online and on bl, but i don't know anyone in RL who really likes it like me.

They've only done it a few times, and i think they haven't really experienced the drug enough to know its potential. Which is fine, I never try to influence them or go on about mxe like i do on bl hahaha.

 

[Xorkoth]

It's not stimulants in general that are dangerous to take with MXE, it's serotonin releasers. Ritalin/methylphenidate is purely a dopaminergic stimulant so it doesn't provide the same dangers in mixing with MXE.

 

[Help?!?!]

While I agree everyone should heed caution as always but their are few anacdeotal reports of problems like yours . Don't forget that sometimes things happen, like I know for a fact if I become even a bit dehydrated sober, I'll get a building headache until I fix it. Your new here so you may not know this(lol) but it is KNOWN that MXE seems to cause dehydration or something like it were you really should be making sure to drink a lot of water on it. Sometimes when I get up to piss I just gulp down sink water for like a solid minute. I doubt anyone has told you this yet as it seems like only heavy users seem to notice. As far as I know, only MXE's SERT affinity is known, it's listed as a serotonin transporter, it does not say SSRI though from what I understand both can have similar properties.

I just don't like it because to this day people still go on about MXE's mu agonism or loving MXE's dopamine properties. The affinity is either negligible or non existent.

I've personally had many experiences with MXE and releasers, high doses too, and never had a problem. Obviously this is only for me but still others have said the same thing, out numbering the "Holy shit I almost died!!!". Hell I've even combined multiple psyches, 3-MeO-PCP, as well as MXE(again just because I'm an idiot doesn't mean you have to be!).

No offense Xork, but you took a strong serotonin releaser compared to MDMA, felt shit the next day, and suddenly this is the factor I'm sure is important. Let me ask, how many people in this world thought they were dying or "poisoned" by chemicals, especially psyches?

I was actually just reading Albert Hofmann's B-Day story and in it during the ride home, he told his assistant that he was poisoned or dying but once the house doctor arrived the only sign of anything he could find was mydrasis. When he realized he wasn't in danger he relaxed, and the rest being history!

 

[Xorkoth]

Well I hear what you're saying, but I had taken 4-FA many other times, this reaction was unique. Also it changed the nature of the MXE trip as well, the report I wrote on it details that. At the same time, I guess you've taken those combinations many times and been fine.

I guess I just feel the need to comment about it because I was warned before I did it, and I didn't listen, and had a worrisome reaction. And I'm not the only person who has either. So better safe than sorry.

 

[Mycophile]

I doubt I'll ever try MXE and I haven't even read much about it but I have a fascination with Ketamine which I've never been able to find so I was just curious:

Is MXE dangerous to take with Klonopin and Prozac?

Does it interact badly with either?

Also, it's legal in the U.S. right?

Just wondering.

 

[xammy]

About MXE + serotonin releasers..

Someone said the chemist who invented MXE is/was a bluelighter. I suppose there isnt a way to get his opinion about combining MXE with serotonin releasers if he had any knowledge about that?

Personally I have no guts to combine it with mdma/serotonin releasers/stimulants. Someone wrote that there are over 10 reported negative reactions? Thats too much for me. Even 1 is. More than likely it wouldnt kill me but I think the feeling is just not worth the possible death. But after all, who knows what the long term effects after using these all kind of RC's are.

 

[Ballz_Trippington]

I doubt I'll ever try MXE and I haven't even read much about it but I have a fascination with Ketamine which I've never been able to find so I was just curious:

Is MXE dangerous to take with Klonopin and Prozac?

Does it interact badly with either?

Also, it's legal in the U.S. right?

Just wondering.

I have no idea if MXE would be safe with those 2 chemicals but MXE has some strange interactions with some other drugs. So I would proceed with extreme caution.
We are not allowed to discuss the legality of chemicals on BL (as far as I know) but a really good way to find out about a drug's legality in a given country would be to simply look it up on Wikipedia.
I also had a facination with Ketamine right up until I tried it. I hated it too much to explore it to "k hole" levels. I might enjoy it more if got to experience that. MXE is just better in every way if you ask me but I still don't truly adore it until it's gets near the "m-hole" and things get really psychedelic. However, in what little experience I have with disacociatives I've come to realize that drugs like MXE and Ketamine are just not for everyone and possibly not for most people. There is way more mind fuck with dissociatives than with most other psychedelics. When I'm peaking on MXE I often keep forgetting where I am even if I'm in my own house. It can get very confusing to the point that some people may freak out during such an experience.

 

[vortech]

So I had the thought the other day when I was looking for the right word for someone who has thoroughly tripped on MXE, or more specifically someone who has had at least one 'hole' experience with the drug. And then it just rolled off me- they're Mexperienced.
(The Jimi Hendrix album 'Are you Experienced?' popularized experienced to imply someone who has tripped on LSD. I felt it only natural to extend the term for MXE's unique trip quality.)

Ballz Trippin, you make a good point about how arylcyclohexylamines are not for everyone because the 'disembodiment' sense can be more extreme than with the classical psychedelics. As a generalization it seems like people who reach hole territory on this class of drugs fair better if they have already been experienced with the classical psychedelics, know some things about set and setting, know how to let go in ego-detachment/ego-death, and are comfortable with possibly exploring the 'darker' parts of their inner space.

 

[vortech]

As for the serotonin releasing drug combos, YES there is potential for overload/serotonin syndrome because MXE has proven SRI (serotonin reuptake inhibition) properties.

Combination with Klonopin should be safe in moderation with both. There is a long history of safe clinical use of benzodiazepines co-administered with dissociative anesthetics. Risk of CNS depression is only significant if being combined with alcohol and/or opiates (or if taking a large dose)

 

[Mycophile]

As for the serotonin releasing drug combos, YES there is potential for overload/serotonin syndrome because MXE has proven SRI (serotonin reuptake inhibition) properties.

Combination with Klonopin should be safe in moderation with both. There is a long history of safe clinical use of benzodiazepines co-administered with dissociative anesthetics. Risk of CNS depression is only significant if being combined with alcohol and/or opiates (or if taking a large dose)

Thanks,

So what if one were to mix Klonopin and Prozac with Ketamine?

 

[xammy]

Yeah MXE at high doses with music is incredible, that's what I was doing when I had my M-hole experience that I wrote about. Laying down, hit of cannabis (or not, but it synergizes), music. Give Shpongle a try with it, my personal favorite (by far) is Nothing Lasts But Nothing Is Lost (the album)... it seems made for the MXE experience, to me. I actually have listened to that album most of the times I've done full doses of MXE, it's that good.

That Shpongle album is one of my favorites too. I tried that last night and it was indeed incredible. My dose was low tho, did ~50mg over the night with cannabis but definitely doing it again with higher doses. Shpongle vibes are kinda unique, I havent really heard anything even remotely similar sounds. Other psy artists I know haven't been able to achieve same kind of multidimensionality as Shpongle. Kudos to this group.

 

[vortech]

Thanks,

So what if one were to mix Klonopin and Prozac with Ketamine?

I had to do some research on Ketamine's interactions with SSRIs to confirm, and it seems that the SRI properties of ketamine (compared to MXE) are very weak and thus should not present any significant interactions. However, the serotonergic system is not the only place there could be an interaction between the two drugs. I did find this:

"Certain SSRI's also have an influence on expression of P450 liver enzymes, which has implications towards ketamine's N-demethylation into norketamine. Fluvoxamine (Luvox) for example, is an inhibitor of CYP: 1A2; 2C9; and 3A(4,5,7) enzymes. Fluoxetine (Prozac) is an inhibitor of CYP: 2C19 and 2D6. Sertaline (Zoloft) is an inhibitor of the CYP2C9 enzyme. Of the three aforementioned SSRI's, only Fluoxetine (Prozac) does not interfere with the enzyme expression of CYP3A4, CYP2B6, and CYP2C9.
"
So while Prozac does not interfere with this enzyme expression, it seems other SSRIs do.

 

[Xorkoth]

That Shpongle album is one of my favorites too. I tried that last night and it was indeed incredible. My dose was low tho, did ~50mg over the night with cannabis but definitely doing it again with higher doses. Shpongle vibes are kinda unique, I havent really heard anything even remotely similar sounds. Other psy artists I know haven't been able to achieve same kind of multidimensionality as Shpongle. Kudos to this group.

Yeah I totally agree. Shpongle is the most organic sounding electronic music I have ever heard. That guy is a genius, straight up. It's so layered and complex, it seems to embody the psychedelic experience in sound. On MXE it's unbelievably perfect. And I think Nothing Lasts But Nothing Is Lost is their most varied and complex album. A lot of people I know prefer Are You Shpongled, but I don't (though that one is great too).

 

[Mycophile]

I had to do some research on Ketamine's interactions with SSRIs to confirm, and it seems that the SRI properties of ketamine (compared to MXE) are very weak and thus should not present any significant interactions. However, the serotonergic system is not the only place there could be an interaction between the two drugs. I did find this:

"Certain SSRI's also have an influence on expression of P450 liver enzymes, which has implications towards ketamine's N-demethylation into norketamine. Fluvoxamine (Luvox) for example, is an inhibitor of CYP: 1A2; 2C9; and 3A(4,5,7) enzymes. Fluoxetine (Prozac) is an inhibitor of CYP: 2C19 and 2D6. Sertaline (Zoloft) is an inhibitor of the CYP2C9 enzyme. Of the three aforementioned SSRI's, only Fluoxetine (Prozac) does not interfere with the enzyme expression of CYP3A4, CYP2B6, and CYP2C9.
"
So while Prozac does not interfere with this enzyme expression, it seems other SSRIs do.

So in other words, taking Ketamine while on Prozac and Klonopin is safe.

Thanks

 

[GolemGolem]

Yeah I totally agree. Shpongle is the most organic sounding electronic music I have ever heard. That guy is a genius, straight up. It's so layered and complex, it seems to embody the psychedelic experience in sound. On MXE it's unbelievably perfect. And I think Nothing Lasts But Nothing Is Lost is their most varied and complex album. A lot of people I know prefer Are You Shpongled, but I don't (though that one is great too).

I just gotta say as a sucker for simple forms....snarky puppy and some more exploratory new jazz masters that complex tight sound, my word.....my mind has been blown.