The Main 5-MAPB Thread

[Transform]

The moderators do generally remove such chit-chat. You don't get to see the behind the scenes action but already in this thread there are five moderated posts.

In this case the discussion has remained because we feel there is something which can be learnt from it. Slang is a pain at the best of times but when it conflates two totally different classes of drugs I think clarification is important.

 

[fastandbulbous]

Hello it's me again (I know I've not been here much of late)

Amyone wanting something very close to MDMA needs to seek out 6-MAPB. In binding studies, 6-APB comes very close to MDA; 5-APB doesn't have an oxygen in the right position/orientataion to make the DAT protein work in the right way (it needs to be at the meta position for that to work, which it is with 6-APB. 5-APB has little dopaminergic activity, hence people monging/falling asleep as the oxygen atom is in the wrong position for optimal dopaminergic activity). Methylating the amine of 6-APB will give less activity at the 5HT2a receptor, making it less trippy (compare MDA with MDMA), but will give it more clout as something that causes more dopamine releasse - hence more stimulating and closer to MDMA. Basically 6-MAPB is going along the right path if you want something similar to MDMA (the dihydrobenzofuran will be a bit closer as the aromatic 'planar' is leaning towards 5HT2a agonism - flat molecules work best at that receptor, which is why LSD & bromodragonfly are so bloody potent - the joy of conjugated systems!). So the closest to MDMA is going to be 6-MADBP, but 6-MAPB will be a close second.

On a slightly different note 5-MeO-6-APB should be a superb 5HT2a agonist - it's planar, due to the aromatic nature of the furan ring, has the 2,5-dimethoxy type substitution pattern with a hydrophobic group at the 4 position. A sort of aromatic, cyclicized version of DOM (STP). One can only wait and see the way things unfold!

I shall now retire to the murky recesses and possibly plan another bout of gibbering for the future! :D


Oh as an afterthought, 6-MAPB can't be metabolized to alphamethyyldopamine (as MDA/MDMA are), so less likelyhood od crushing depresssion in the days following ingestion

 

[Mike_Power]

F&B! can you drop me a line? I need to talk to you... usual address.

 

[Limitbreaker]

How much would u suggest for first time? I've tried serotoninergics, 6-APB before. For 6-APB 125+125mg was too much, 160-170mg as well, 140~~ is usually perfect dose.

Also, does this have same solubility problems as 5/6apb? Did anyone try this P.R. or can compare p.r. to insufflated?

 

[David the Chansey]

How much would u suggest for first time? I've tried serotoninergics, 6-APB before. For 6-APB 125+125mg was too much, 160-170mg as well, 140~~ is usually perfect dose.

100mg seems to be the amount that most people have tried for their first time. My preferred 6-APB dose is about 200mg, 5-APB around 140mg (my batch is incredibly strong), so I personally would try 5-MAPB at 125mg with no anxious feelings. I hope you can extrapolate something from this.

 

[petebog]

Oh as an afterthought, 6-MAPB can't be metabolized to alphamethyyldopamine (as MDA/MDMA are), so less likelyhood od crushing depresssion in the days following ingestion

Is something similar happening with 5-MAPB? I ask because the lack of that crushing depression seems to be a great advantage of 5-MAPB as opposed to MDMA or meph, for a very similar and enjoyable high.

 

[Sepher]

FAB's post sure is interesting Petebog. I've read that 5-MAPB is an even better serotonin releaser even than MDMA. I don't have figures to back that up, wonder if others might or what others' thoughts are on that? But anyways, that being said I've never had Suicide Tuesdays with any of the MAPB/APBs and I dose high. High enough to get head zaps which is indicative of serotonin depletion when I've had one weekend too many at them.

I've never, ever heard of alpha-Methyldopamine before, just been reading up on it. That's concerned more with neurotoxicity rather than mood, long-term neuronal damage, would that be right? It buggers about with dopamine though, is that at the root of the Suicide Tuesday thing then?

 

[Folley]

^ a-Me-DA as well as other dopaminergic free radicals don't really cause the whole "suicide tuesday" phenomena, that's more from direct neurochemical release.. AFAIK.

Instead they do damage by entering and destroying serotonin receptor sites in the long term, causing lasting damage that can, in some cases, be permanent. I would imagine a-Me-DA and other metabolites to be largely responsible for the toxic-type side effects, although I don't think quite enough is known on the whole process to say for sure.

 

[ebola?]

a-Me-DA as well as other dopaminergic free radicals don't really cause the whole "suicide tuesday" phenomena, that's more from direct neurochemical release.. AFAIK.

This is actually an open zone of controversy. In addition to presenting danger of exacerbating neurotoxicity, alpha-methyl-DA acts as a dopamine antagonist. Dopamine antagonists can feel pretty dysphoric. However, as far as I've been able to gather, amd is formed from MDMA mostly hepatically and doesn't readily cross the BBB, so its behavioral relevance is unknown.

Instead they do damage by entering and destroying serotonin receptor sites in the long term

This is not right. The current hypothesis is that toxic metabolites of dopamine and some entactogens are taken up by serotonin TRANSPORTERS in situations where there is transporter reversal (ie, with serotonin releasers) and serotonin depletion. It is my understanding that the processes leading to damage begin in the cell body, after these toxic metabolites have been taken up.

It doesn't make much sense to talk about a "destroyed receptor site", as receptors downregulate and upregulate all the time.

ebola

 

[Folley]

Ah, I'm sure that's right. Admittedly I know jack shit all about chemistry, so it's no wonder I confused a "receptor" for a "transporter" aha


I agree though, a-Me-DA and metabolites like it doesn't seem to be the major source of short term damage to me, which was the point I was trying to make. So just because 5-MAPB does not have this property likely doesn't make it any safer than other serotonergic drugs.

 

[Limitbreaker]

again, has anyone tried p.r.? you tihnk its gonna be stronger than insufflated?

 

[ebola?]

I agree though, a-Me-DA and metabolites like it doesn't seem to be the major source of short term damage to me

Honestly, the jury's still out. There has been insufficient study to speak to the hypothesis. However, to be clear, we shouldn't assume that the same processes that cause neurotoxicity also cause unpleasant 'come-downs' and hangovers.

ebola

 

[any major dude]

Hello it's me again (I know I've not been here much of late)

Amyone wanting something very close to MDMA needs to seek out 6-MAPB. In binding studies, 6-APB comes very close to MDA; 5-APB doesn't have an oxygen in the right position/orientataion to make the DAT protein work in the right way (it needs to be at the meta position for that to work, which it is with 6-APB. 5-APB has little dopaminergic activity, hence people monging/falling asleep as the oxygen atom is in the wrong position for optimal dopaminergic activity). Methylating the amine of 6-APB will give less activity at the 5HT2a receptor, making it less trippy (compare MDA with MDMA), but will give it more clout as something that causes more dopamine releasse - hence more stimulating and closer to MDMA. Basically 6-MAPB is going along the right path if you want something similar to MDMA (the dihydrobenzofuran will be a bit closer as the aromatic 'planar' is leaning towards 5HT2a agonism - flat molecules work best at that receptor, which is why LSD & bromodragonfly are so bloody potent - the joy of conjugated systems!). So the closest to MDMA is going to be 6-MADBP, but 6-MAPB will be a close second.

On a slightly different note 5-MeO-6-APB should be a superb 5HT2a agonist - it's planar, due to the aromatic nature of the furan ring, has the 2,5-dimethoxy type substitution pattern with a hydrophobic group at the 4 position. A sort of aromatic, cyclicized version of DOM (STP). One can only wait and see the way things unfold!
I shall now retire to the murky recesses and possibly plan another bout of gibbering for the future! :D

Oh as an afterthought, 6-MAPB can't be metabolized to alphamethyyldopamine (as MDA/MDMA are), so less likelyhood od crushing depresssion in the days following ingestion

Hey man, good to see you around again! Hope you're well. And very interesting post.I was not long ago thinking to myself about potential for psychedelic amp type things blossoming from the benzofuran class that seems to be all the rage these days. Quite curious about the 5-MeO-6-APB, though the trend for the moment is obviously towards less psychedelia & more ecstasy-alike type stuff.

 

[sh1va]

Yoyoyo, i'm thinking of investing in some 5-MAPB, but I was wondering if anyone could tell me about how it'd affect my tolerance for mdma?
I'm currently on a break from mandy, to try and get my tolerance to lower a bit, this seems like an awesome chemical, but I don't want to take it if it'll just completely undo the break I've been on..
Any thoughts?
ta!

 

[cannibalsnail]

Nope. They fully share their tolerance.

 

[kidklmx]

Well, AFAIK tolerance comes from downregulation of your serotonin receptors. If that's the case then a serotonin releaser will not help here.

That said, serotonin receptors come back pretty quickly. If you're trying to return the magic of MDMA, then I'm not sure if this will do any harm, but it's best not to. Maybe you should try a Phenethylamine-type psychedelic in lower doses?

 

[Johnyderp]

Be careful as always with these new RC's. I recently bought 5-MAPB from a very top notch trusted vendor. First experience was great, very much like M1. I took 140mg or a bit more; I only remember coming to the peak then coming down. Anywho, foolishly I decided I should do it again the next day. In my "infinite wisdom" I thought to myself, " maybe if I take some passion flower I can have a better experience."

I took 450mg of Passion Flower (thank god it wasn't extract) 1 hour prior to taking 175mg 5-MAPB then another dose of 90mg of 5-MAPB 45 minutes later. I can't recall much of what happened through the night but my arms and legs were convulsing heavily, I was drenched in sweat, my hands and feet were contorted, could barely move my mouth to talk because of insane bruxism and my neck tremoring. Me thinks the beginning of serotonin syndrome.

I almost went to the ER but thankfully I had pharm quality etizolam on hand. Drank a massive glass of white grapefruit juice and 4 mg of the etizolam. It's been 5 days and I'm getting brain zaps left and right. They were the most intense last night to the point that if I held still they would slowly build up into cascading fashion where if I didn't move or "shake my self out of it" I felt like I was going to seize. The brain zaps also include the feeling of an electrical charge firing throughout my arms to the tips of my fingers.

Today is better though, and I am on regimen of over a dozen vitamins and supplements along with exercise. Also abstaining from any drug. In conclusion just be safe and careful. Never Mix this with a MAOI. Take care :D

 

[TryptamineBunny]

^^ It takes courage to admit such mistakes and might just help prevent another from making the same mistake. To me this is the essence of harm reduction.

Thanks for posting honestly.

 

[ashxcore]

Be careful as always with these new RC's. I recently bought 5-MAPB from a very top notch trusted vendor. First experience was great, very much like M1. I took 140mg or a bit more; I only remember coming to the peak then coming down. Anywho, foolishly I decided I should do it again the next day. In my "infinite wisdom" I thought to myself, " maybe if I take some passion flower I can have a better experience."

I took 450mg of Passion Flower (thank god it wasn't extract) 1 hour prior to taking 175mg 5-MAPB then another dose of 90mg of 5-MAPB 45 minutes later. I can't recall much of what happened through the night but my arms and legs were convulsing heavily, I was drenched in sweat, my hands and feet were contorted, could barely move my mouth to talk because of insane bruxism and my neck tremoring. Me thinks the beginning of serotonin syndrome.

I almost went to the ER but thankfully I had pharm quality etizolam on hand. Drank a massive glass of white grapefruit juice and 4 mg of the etizolam. It's been 5 days and I'm getting brain zaps left and right. They were the most intense last night to the point that if I held still they would slowly build up into cascading fashion where if I didn't move or "shake my self out of it" I felt like I was going to seize. The brain zaps also include the feeling of an electrical charge firing throughout my arms to the tips of my fingers.

Today is better though, and I am on regimen of over a dozen vitamins and supplements along with exercise. Also abstaining from any drug. In conclusion just be safe and careful. Never Mix this with a MAOI. Take care :D

Glad you're okay, but mixing MAOIs with serotonin releasers is always an open invitation for serotonin syndrome.

Anyhow, this stuff is excellent snorted in 50mg bumps. I've been on it now for around 10 hours with less than 200mg to start off with. Empathy, confidence, creativity, insight, sedation. Euphoria.
Doesn't seem to be vasoconstrictive. Pupils are massive. Less jaw tension than with meph or 3mmc. Clogs up your nose, though!! This is the best RC I've had in a very very long time.

 

[David the Chansey]

Sedation? The only thing (to me) that made this a consideration over 6-APB was it supposedly being closer to MDMA, which I assumed meant it was stimulating.