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The Big & Dandy MDAI Thread: Second Dose

lady_stardust said:
wow - thanks so much for the link. damn, i wish i had known about this before i bought the stuff! (i haven't read the link yet, so forgive me if i'm asking a question answered on that site - but do you think it would help if i quit the welbutrine for a week beforehand? tho i'd hate for the same thing to happen again....

thanks again - oh, so after that bad experience did u do it again and have a better/good one? had u gone off the Peroxitine?

peace
g
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I've never tried MDAI again, I'm still taking Paroxetine.
I think you should break your treatment with Wellbutrin, even only 1 week, if you really need it.
 
mllx said:
I've never tried MDAI again, I'm still taking Paroxetine.
I think you should break your treatment with Wellbutrin, even only 1 week, if you really need it.
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do u think that will help? inaccidently took a tiny bit yesterday and the same thin happened, tho not as sever: feverish, cold, body aches and spasms.or shoould i just flush it?
 
lady_stardust, you can't take MDAI, MDMA, or other serotonin-releasing compounds if you're on antidepressants. It will lead to the symptoms you're describing. St. John's Wort and 5-HTP are also bad things to combine with MDxx drugs.
 
Tried ethylphenidate and MDAI today, and can say it is quite a lovely combination! - note I have never had MDMA. 4-FA is the closest Empathogen. YMMV

T+ 0 : MDAI 90mg orally
T+45 min : 45mg orally
T+1 hr : 40mg Ethylphenidate insufflated
T+1 hr 30 min : 25 MDAI insufflated (no discomfort) + 30mg Ethylphenidate
T+2 hr : 30mg Ethylphenidate + 1.5mg etizolam

At first I felt a calm sense of peace and body temperature changes, which slowly progressed into a pleasant sociable and empathetic state. I felt compelled to message a few people on facebook, talking easily and openly about many topics I would usually be too anxious to bring up. Not only was i not anxious, I was very confident. I could approach more personal topics in a far better manner than I usually would. I was very chatty and energised; this could become a favourite for partying / socializing.

Music, sound and cognition was enhanced. I felt the need to dance, something I don't often do, especially with such confidence. Playing guitar was great, very creative and fun playing along to some good songs.

As I continued with the Ethylphenidate it became less special; it's more-ish nature is something I am quite susceptible to. This leveled off into a plateau which was mentally comfortable and generally pleasant. Music not as great anymore, but still enjoyable. Some chills through the body noted.

T+3 - Ethylphenidate is overpowering MDAI I believe. I feel slightly compelled to do the usually more mundane tasks of life, instead of having fun and socialising. I am becoming more driven to write, study, organise, or complete some sort of project. It is not forceful with MDAI included though. Usually Ethylphenidate will compell me very strongly to do these things, where as this time, I can alternate quite easily.

T+4 - Some residual stimulation, etizolam has wiped out any comedown. Off to gymnastics in 2 hours for a good stretch. I better avoid any strenuous gymnastics exercises tonight.

Overall, I am extremely impressed. A perfect combination for a relaxing day with family, friends, or maybe a small party.

Finally, I'm under the assumption this combination is not very neurotoxic. If I'm not mistaken neruotoxicity is largely influenced by a flood of serotonin and a DA agonist. (4-FA + MDAI, 4-FA + Methylone). Seeing as Ethylphenidate is a reuptake inhibitor, the same issues are not involved. (Ritalin is neuroprotective I believe).

I would appreciate if anyone with more knowledge could confirm/deny this? Or any other thoughts on the combination.
 
I've taken MDAI a couple of times in the recent months. Usually I'm no fan of the substance, but last time the addition of 150 mg caffeine to 250 mg MDAI had a huge impact and made the experience very pleasurable. Usually I'm just very sedated and cloudy on MDAI, but the addition of a stimulant made it quite fun. I also have ethylphenidate now but I'm not going to combine them, my BP gets too high on EPH alone, I don't need any further rise in my BP (quite the opposite).
 
zn13bt said:
lady_stardust, you can't take MDAI, MDMA, or other serotonin-releasing compounds if you're on antidepressants. It will lead to the symptoms you're describing. St. John's Wort and 5-HTP are also bad things to combine with MDxx drugs.
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ZN13bt,
thank u for this. the article i read indicatednthat the case reported where Wellbutrin was involved was not "simple". am inwrong to consider that Wellbutrin, because it is not an SSRI, is not one to b to totally concerned about? i ask, not to dispute u, but to verify, or disqualify,my assumptions....i can certainly do w/o MDAI or Wellbutrin for that matter....just curious... thanks for your input! ... always, my fellow B & GLs,....

peace
g
 
SSRIs are not a problem in combination with MDMA. They will not lead to serotonin syndrome, they merely blunt the empathogenic effects of the roll. This is a combination that many people, including myself, have taken safely over the decades.

When combining SSRIs/SNRIs with MDMA, you will still feel the stimulation and the trippy effects attributable to the drug. However, in the case of MDAI, it is - as I understand it - solely a serotonin releaser, so combining SSRIs/SNRIs with it will likely produce little if any effect. Still, it won't be a dangerous combination since it's not an MAOI.

Just to explain this a little further in case you are confused, the pharmacological action of the SSRI prevents the serotonin efflux normally provided by MDMA or similar at the very same receptor, thus negating the danger of extra serotonin building up in the presence of an SSRI. Think of it as a uni-directional revolving door, whereby MDMA reverses the direction of that door and pumps serotonin back out of the neuron in to the synaptic gap. SSRIs merely place a chock in the door, preventing or slowing the flow of serotonin in either direction (the normal "direction" being into the neuron). The MDMA is trying to spin the door in the opposite direction to "normal" flow, but there's a chock in the door preventing it from doing that very efficiently.

If, theoretically, you took a large enough dose to overcome this particular action of the SSRI, you still wouldn't be in danger because the MDMA would then be overriding the effect of the SSRI that you were concerned about, thus still negating the the worry of dangerous serotonin build-up.

The only thing you have to watch out for is serotonin releasers which are also MAOIs, such as aMT. These are indeed contraindicated with SSRIs and similar drugs. Also, 5-HTP is contraindicated with strong SSRIs because it overrides the rate-limited enzyme conversion of tryptophan into serotonin, producing a rapid rise in serotonin not exacted by the mechanism of efflux as seen with MDMA. I have yet to see any serotonin syndrome reports of 5-HTP with SSRIs, but the possibility exists and they are clinically contraindicated.
 
Survived Abortion said:
SSRIs are not a problem in combination with MDMA. They will not lead to serotonin syndrome, they merely blunt the empathogenic effects of the roll. This is a combination that many people, including myself, have taken safely over the decades.

When combining SSRIs/SNRIs with MDMA, you will still feel the stimulation and the trippy effects attributable to the drug. However, in the case of MDAI, it is - as I understand it - solely a serotonin releaser, so combining SSRIs/SNRIs with it will likely produce little if any effect. Still, it won't be a dangerous combination since it's not an MAOI.

Just to explain this a little further in case you are confused, the pharmacological action of the SSRI prevents the serotonin efflux normally provided by MDMA or similar at the very same receptor, thus negating the danger of extra serotonin building up in the presence of an SSRI. Think of it as a uni-directional revolving door, whereby MDMA reverses the direction of that door and pumps serotonin back out of the neuron in to the synaptic gap. SSRIs merely place a chock in the door, preventing or slowing the flow of serotonin in either direction (the normal "direction" being into the neuron). The MDMA is trying to spin the door in the opposite direction to "normal" flow, but there's a chock in the door preventing it from doing that very efficiently.

If, theoretically, you took a large enough dose to overcome this particular action of the SSRI, you still wouldn't be in danger because the MDMA would then be overriding the effect of the SSRI that you were concerned about, thus still negating the the worry of dangerous serotonin build-up.

The only thing you have to watch out for is serotonin releasers which are also MAOIs, such as aMT. These are indeed contraindicated with SSRIs and similar drugs. Also, 5-HTP is contraindicated with strong SSRIs because it overrides the rate-limited enzyme conversion of tryptophan into serotonin, producing a rapid rise in serotonin not exacted by the mechanism of efflux as seen with MDMA. I have yet to see any serotonin syndrome reports of 5-HTP with SSRIs, but the possibility exists and they are clinically contraindicated.
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I tried myself MDMA-like drugs (not MDMA itself, but M1 and 4-FA) without any problem, as you said.
But any low dose of MDAI leads to SS-like symptoms. I don't know why, anyway MDAI is a RC, so little is known about it.
Maybe MDAI has any other 5-HT release mechanism than SERT binding?

Anyway, combination with any SSRI seems dangerous enough to be cautious.
 
Sorry, I think I was getting mixed up with DXM, which is definitely not safe to take with SSRIs.

Personally I've had bad reactions taking methylone while on St. John's Wort, or with taking 5-HTP the evening after taking some 6-APB that afternoon. Like very bad nausea, hot flashes, unpleasant agitation, and feeling like I've poisoned myself. So I feel like these combinations are pretty unsafe. I suspect combining them with MDMA or MDAI would have similar effects on me (no, I'm not going to try it to see... ;)) But I guess it's an idiosyncratic reaction if there are lots of other people who take 5-HTP with MDMA and have no problems with it.
 
lady_stardust said:
(btw, how do u drinkthe cocoa powder? isn't it extremely bitter? how much at a time do u take?)
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Mix it with milk, and use a food processor'ish thing to stir it up as it's not easy done by hand. Doesn't taste that well, so old fashioned milk makes it the best taste. You could add some protein powder into the mix to sweaten it up - and add proteins aswell which isn't all bad.

lady_stardust said:
meanwhile i got the MDAI yesterday and did some and wanted to die! either it isn't MDAI or my body chemestry is fucked....I felt feverishand misserable, no pleasurable feelings at all....ididn't do much tho, but i can't imagine a higher dose would help....i was/am experiencing very mild (in my book anyway) opiate wds, could that have been the reason?
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My latest batch was white diamond shiny flakes. If you got sweaty and all that, you could be low on serotonin and should wait a while and eat stuff that will boost your serotonin levels before trying again - or get a friend to test it aswell. If he gets same reaction - throw the powder away as it's something wrong with it. I would say normally that 150mg is required for a a feeling at all. If you get a bad one, have benzo available as it will kill the trip. Sure you can also do 50 bumbs each 30 minutes, you should get a good feeling not a bad one - if a bad one stop eat a benzo and get some food into you and email your vendor for a money back or other compund.
 
steingalkrs said:
Mix it with milk, and use a food processor'ish thing to stir it up as it's not easy done by hand. Doesn't taste that well, so old fashioned milk makes it the best taste. You could add some protein powder into the mix to sweaten it up - and add proteins aswell which isn't all bad.



My latest batch was white diamond shiny flakes. If you got sweaty and all that, you could be low on serotonin and should wait a while and eat stuff that will boost your serotonin levels before trying again - or get a friend to test it aswell. If he gets same reaction - throw the powder away as it's something wrong with it. I would say normally that 150mg is required for a a feeling at all. If you get a bad one, have benzo available as it will kill the trip. Sure you can also do 50 bumbs each 30 minutes, you should get a good feeling not a bad one - if a bad one stop eat a benzo and get some food into you and email your vendor for a money back or other compund.
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thanks - alL good info

btw, i did email the vendor and never heard back. meanwhile inhave noticed that most of the RCs that i am interested in r not currently shipping to the US......wtf?!
 
lady_stardust said:
will bee pollen work better than 5-HTP?
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From what I understand bee pollen contains tryptophan, which in turn makes 5-HTP which in turn makes serotonin. So foods or supplements with large doses of tryptophan will work aswell, however 5-HTP is stuff bebore your body makes it into serotonin so it would definately be the best.

As people mention, certain anxiety pills or such, or benzo, will effectively kill the MDAI/MDMA experience 100%.

If doing MDAI or MDMA benzo is what you use to kill it, so be sure you do not have any benzo in your system!

Some quick info I found on the benefits of bee pollen, which I see now also contains phenylalanine which in turn become tyrosine which is a blessing aswell, as it gives you dopamine. I love bee pollen more and more, :)

http://www.livestrong.com/article/543000-the-essential-amino-acids-in-bee-pollen/
 
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Okay so my favorite RC that mimics MDMA is 6-apb but I can't get any at the moment so I have some MDAI now...I read somewhere that alone it doesn't do very much. Could I mix with a stimulant such as ethylphenidate? What kind of effect would a DNRI mixed with a SSRA do? I have the white crystal-light brownish MDAI from a pretty reputable vendor.
 
A lot of rcs are around if you cannot find rcs your not Looking. I still have a year old or older bag of MDAI I keep forgetting that I actually purchased some time ago. I never enjoyed it but it was ok with crystal
 
Tweak Thizz said:
Okay so my favorite RC that mimics MDMA is 6-apb but I can't get any at the moment so I have some MDAI now...I read somewhere that alone it doesn't do very much. Could I mix with a stimulant such as ethylphenidate? What kind of effect would a DNRI mixed with a SSRA do? I have the white crystal-light brownish MDAI from a pretty reputable vendor.
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6-apb is pretty much the only rc that I see in headshops try harder.
 
Got some MDAI from a new vendor today. It's very powdery, pure white, doesn't smell overly offensive but definitely off-neutral. Appearance reminds me of MPA but it doesn't taste like it. It was labelled as "supersynth MDAI".

Likelihood that it's actually MDAI, anyone?
 
Machete said:
Got some MDAI from a new vendor today. It's very powdery, pure white, doesn't smell overly offensive but definitely off-neutral. Appearance reminds me of MPA but it doesn't taste like it. It was labelled as "supersynth MDAI".

Likelihood that it's actually MDAI, anyone?
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Seems plausible that it's just MDAI crystals mashed down to powder but I'm not really sure what to do with it yet. Will allergy test today.
 
Tweak Thizz said:
Okay so my favorite RC that mimics MDMA is 6-apb but I can't get any at the moment so I have some MDAI now...I read somewhere that alone it doesn't do very much. Could I mix with a stimulant such as ethylphenidate? What kind of effect would a DNRI mixed with a SSRA do? I have the white crystal-light brownish MDAI from a pretty reputable vendor.
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I have mixed another SRA (IAP) with Ethylphenidate with great results that somewhat resembled somewhere between Methylone and MDMA. Worth a try, just remember to be careful with your dosing as with any combo, as they'll likely potentiate each other.
 
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