Codeine and CWE Megathread - The long awaited!

[Mr Blonde]

True enough, but taking 30ml of robo DX instead of 10ml standard dose
and feeling a bit odd with fully expanded pupils I'd assume is unusual for most.

William White, of the DXM FAQ fame, started his research after accidentally double dosing on cough syrup and noticing odd effects. So some people must be sensitive to it. I only use a regular dose of DXM with codeine and that's plenty for me.

I tried taking codeine a few times, haven't touched it in a few years now though.

First time I died, i did a CWE on 60mg codeine. Didn't feel anything from it
so a week later I tried 100mg codeine from a CWE. Felt a very very mild relaxation
So 2 weeks later I CWE 200mg codeine, again it was a mild relaxation but now my mouth was incredibly dry.

Some people are deficient in the enzyme that metabolizes codeine to morphine (CYP2D6), and so will not experience the full effects that others do.

Also, for some people opioids are just not for them or are an acquired taste.

 

[mindtools]

internettoughguy, I "truly" felt codeine on my 10th or so attempt, so maybe your time has't come yet

 

[leigh12]

^^ it took me a few heavy oxy sessions b4 i noticed the codeine working

tho nowdays i only use my daily methadone and 7mg xanax , wich doesnt hit me til maybe 6pm if i dose a 9am , but it does hit me like a hammer to the head n makes for a mad sleep, but my dreams have been disturbing and realistic as shit since, i scream shit out in my sleep , mostly nasty abusive shit lol , wierd . and my x from 5 years or more ago always comes into the dream somehow, tho that cld be from the antidepressants (avanza 20mg) , bak in melbourne wen i was drivin to city to score for mates ill have a (roughly) 150mg shot theyd shout me b4 i head back home but that was once in a blue moon, or a blue week , heroins too dull for me

 

[Divine Moments]

Some people are deficient in the enzyme that metabolizes codeine to morphine (CYP2D6), and so will not experience the full effects that others do.

Also, for some people opioids are just not for them or are an acquired taste.

True that. With regards to the metabolisation, it's a continuum rather than a black/white thing. Some people will be essentially unable to get the effects no matter how much they use, while others will just need to take more. As long as your doing CWEs I see no reason not to keep upping the dose until one either gets the effects you want or get unpleasant side effects... or are using so many boxes at once that it's not worth it

 

[Divine Moments]

I tried taking codeine a few times, haven't touched it in a few years now though.

First time I died, i did a CWE on 60mg codeine. Didn't feel anything from it
so a week later I tried 100mg codeine from a CWE. Felt a very very mild relaxation
So 2 weeks later I CWE 200mg codeine, again it was a mild relaxation but now my mouth was incredibly dry.

then a month after that I decided to go for 480mg dose from a CWE. This time I felt something but it was not pleasant. I kind of just laid on the couch but just felt spaced out and had to keep drinking water. which lasted for about 4 hours but felt no good effects what so ever?

at the time of all these attempts i was using Heron Gold which was 12.3mg per pill I think it was? don't think heron gold have codeine in them anymore.

Just curious what was going on. I'm pretty sure my coldwater extract was fine- usually had clear or a tiny amount of cloudyness in the glass. I have never used any other opiets before so I dont know what I was meant to be feeling apart from what I've read online.

I heard that DXM is metabolised by the same enzyme as codeine, if it helps, i tried DXM once (300mg from cough syrup) and that gave me extremely messed up vision and co-ordination for about 4-5days after where i couldn't even walk straight for a few days. if that info helps at all?

That sounds very much like you are CYP2D6 deficient as Mr Blonde suggested. Same for me - nothing from codeine and very unpleasant effects from DXM. Thank god it doesn't effect most drugs :D

 

[leigh12]

also for people worrying alot about their livers from doin extractions, iv done maybe 400 since i realised it worked, first proper codeine high was on par with oxy , and 3/4 of my codeine highs were on a daily basis, pretty much a year straight, i was abit worried id slightly rooted my liver from it all , until i had a near fatal car accident n asked for a more umm extensive? liver test , and they said its healthy as fuck , so yeh , dunno if im just lucky and have an iron liver , or cwe is just very very smart thinking if ur goin to get high on codeine on the reggie.

i unfortunately went onto iv heroin with a very badly influential ex gf (bipolar, stripper, addict , cutter ( caught her the first night outa jail she stayed at my melbourne house a cpl nights slicing her arms open on my bed , blood everywhere , then caught her again 30 mins later , i totally skitzed it , shed abuse any drug she cld get her hands on , witnessed many of it n it was ugly sitch, name it all, shell abuse it ) and stupid me got back with her after she got outa jail , wich lasted a week, shes the only girl im genuinely scared of , eventually got onto methadone , wich has changed my mindstate and view of life for the better in a WAY I NEVER THOUGHT POSSIBLE , oops caps,

yesterday i decided to try cwe just for some sunday fun, i skipped a methadone dose and waited a extra 5 hrs after the previous days dose worn off , n dosed 600mg (using only 30mg fortes) n noticed maybe 1/10 of the effects id used to get , tho i didnt have the 40mg dxm and umm travacalm wich i used to with it to potentiate, next time if i do it again (codeine) ill do it with the dxm n travacalm , travacalms some bad shit in some situations , fucked up some VERY important friendships in my life in the passed because of that , but if i take it by myself , theres no one to listen to my ramblings lol what dose codeine wld you reccomend for someone whos on 130mg methadone daily?? and how long shld i wait till i dose codeine after my dose has worn off (methadone)??

i havent done codeine now for ages (exept yestday) took n hour to find a pharmacy where im livin now lol,

the main thing is weening of the xanax wich is my no 1 priority concerning my substance use these days , rarely touch illegal stuff, smoke weed once a week, if that , got no tolerance so it just makes me paranoid if i have more than 2 cones. since i moved i dont really know many ppl to get it from so thats another good thing i spose. i just have bacci bongs now if i wake up middle of night to put me bak to sleep , gives me tiny little buzz n i drift back off for few more hours . peace out bluelight friends , ciao mates lol

off topic, but last time i had H , scored from a random wher i liv now, smoked 2 puffs , n copped a rush iv never copped b4 , n thats after my passed ( still occasional but not a habit ) iv use , and i was on 130mg done at the time of smokig it , after i finished the 150mg i was totally hammered (no pun intendd) . i prob smoked 100mg and snorted 50 , then had to drop people home wich was a fun drive lol
lucky got new and easy to drive car, good ol brand spanker black astra 5spd

 

[leigh12]

I def agree with the dxm potentiation thing. I rarely use dxm as a potentiator nowadays, just because I tend to feel the dxm over the codeine, even at low doses (90mg or even less). It's not at the level of tripping on the dx or anything, it just gives this weird, anxious edge to the opiate high. When I 'nod' on dxm and codeine, it's not the usual relaxed opiate nod but feels almost feverish, like when you're half asleep but get stuck in a dream loop over and over.

lol good ol dream loops , if they not bad dreams , iv had hektik dreams for years now , its very disturbing , but one xanax bar n 2 valiums make the dreams more umm "fun" i guess n not negative , plus i wake up in good mood coz of the longer half life

 

[Mr Blonde]

leigh12: It might take a big dose; methadone inhibits CYP2D6. Maybe if you could get your hands on one of the inducers of the enzyme you would have more luck?

 

[The Plague]

I personally found DXM to diminish the effects of Codeine.

Also a side note: I've read on bluelight that SSRIs can diminish the effects of Codeine, but in my experience this is not true. (I am taking 10mg/day escitalopram)

I also seem to be able to stick to a really low dosage and achieve desirable effects. 100mg gets me to where I want to be and I can do this for days in a row without any noticeable tolerance buildup. If I increase the dose to 300mg for example I only get more itching and hardly any more positive effects. I'm also a fairly big guy, any idea what could be causing this?

 

[TripppAR]

I found 50mg's morphine sulphate shot up the arse with a oral syringe worked on par/ better then my best EVER codeine dosing when I was using like xanax, DMX + codeine like 800mg's ... That's what it felt like. It is the same drug though although I cannot wait to get some more morph sulphate and shoot it up my arse haha. It feels incredible and takes only a couple minutes laying on your back


Fuck it was good.

 

[The Plague]

That sounds amazing Trippp, no wonder it's so expensive

How does rectal compare to oral for you?

I haven't tried any harder opioids because they're almost impossible to find for me, however that's probably a good thing!

Is there any truth to C6G being the active metabolite of codeine as opposed to morphine? Perhaps Mr Blonde can shed light on that one

 

[Crankinit]

That sounds amazing Trippp, no wonder it's so expensive

How does rectal compare to oral for you?

I haven't tried any harder opioids because they're almost impossible to find for me, however that's probably a good thing!

Is there any truth to C6G being the active metabolite of codeine as opposed to morphine? Perhaps Mr Blonde can shed light on that one

Well codeine does definitely metabolize into morphine to some extent, the question is whether the morphine is responsible for 100% of the active effect, or whether C6G contributes as well.

 

[The Plague]

Well codeine does definitely metabolize into morphine to some extent, the question is whether the morphine is responsible for 100% of the active effect, or whether C6G contributes as well.

Yes, however according to this source: http://www.ncbi.nlm.nih.gov/pubmed/11092114

"Eighty per cent of codeine is conjugated with glucuronic acid to codeine-6-glucuronide. Only 5% of the dose is O-demethylated to morphine, which in turn is immediately glucuronidated at the 3- and 6-position and excreted renally"

I'm not sure what they mean by immediately, but codeine usually lasts up to a few hours for me.

Sorry if I appear rude, I'm just really curious as to how it really works :D

 

[Divine Moments]

From this article CYP2D6 in the metabolism of opioids for mild to moderate pain.

The text goes into much greater detail but is too long to paste it all here. It's free though, if you want to read it here

 

[The Plague]

From this article CYP2D6 in the metabolism of opioids for mild to moderate pain.

The text goes into much greater detail but is too long to paste it all here. It's free though, if you want to read it here

Wow that is a great chart, thanks for that :D

It would be interesting to conduct an experiment where subjects take a CYP3A4 inhibitor, CYP2D6 inhibitor, or glucuronidase inhibitors along with a dose of codeine and see which groups experience euphoric effects.

 

[Mr Blonde]

I might see if I can find some studies or anything later on; some people do claim that codeine-6-glucuronide is active but there are not that many studies out there to show that this is true.

Also, I had to get a blood test last week as part of some health problems I've had lately and a liver function test was part of it. All enzymes were within normal range, even after quite a while of using almost 300 tablets to get anything from codeine. Still, it's not healthy and I might try and use poppy seed tea instead when I have to but I think I should take a break for a while.

 

[pinkanga]

^^^ Thats good to hear man.

Thought I was gonna get a couple oxy's to have tonight with my cwe, but doesnt look like its happening unfortunately. Ahh well would have been good.

 

[bobbydarren]

Also, I had to get a blood test last week as part of some health problems I've had lately and a liver function test was part of it. All enzymes were within normal range, even after quite a while of using almost 300 tablets to get anything from codeine\

my triglyceride's and cholesterol are stuffed, as in there's way too much in the blood stream. Before my OTC codeine habit both were fine. Nothing has really changed except for the CWE's. Same food, exercise, weight etc. But not something I can discuss with the dr.

I think it is related though because cholesterol is produced by the liver, and [i think] regulated by being converted to bile in the liver, and ofcourse triglyceride's are made in the liver. So seems to make sense to me that if CWE have damaged the liver then I might have these problems

 

[pinkanga]

^^^bobby what is your diet like though? You a fast food junkie? Thats my main curiosity. But you also exercise regularly?

 

[tyrael]

I personally found DXM to diminish the effects of Codeine.

Also a side note: I've read on bluelight that SSRIs can diminish the effects of Codeine, but in my experience this is not true. (I am taking 10mg/day escitalopram)
...

Yes it can and does! Not all SSRI's - again the ones which a metabolised by CYP2D6.

Also a word of caution on SSRI/MAOI's (particularly the older AD's however I would assume all Sertonergic (potentiating) drugs) and DXM .... this can cause Serotonin Syndrome! Albeit not overly common and the dextromethorphan doses would have to be relatively large but still. Something to keep in the back of the mind!

Well codeine does definitely metabolize into morphine to some extent, the question is whether the morphine is responsible for 100% of the active effect, or whether C6G contributes as well.

Agreed. Initially I was taught that the metabolised codeine > morphine was responsible for majority of the (analgesic) effects however doing further self study I'm in two minds on whether this is true and actually which metabolite is most responsible for the active effects!

I might see if I can find some studies or anything later on;
...

Hey M_B that'll rock if you could. Also great if you could forward them onto me! Ya know me, my opies!

.....
some people do claim that codeine-6-glucuronide is active but there are not that many studies out there to show that this is true.
.....

Again, I've heard this also which leads me to become confused slightly.