Brian.Badonde
Greenlighter
- Joined
- Jun 17, 2010
- Messages
- 96
nice.
Last edited:
opiate potentiation is facilitated by cyp2d6 competitive inhibition, not by additive cns depression
i think
No, that's not true. It's anticholinergic action in CNS that is required in most 1st generation antihistamines that really give a boost to opioid action.
Do you mean it boosts the actual activity or the subjective euphoria? I know that there are/were problems with people mixing cyclizine with methadone for injection. Apparently they were attempting to replicate the rush of Diconal. I have never understood why it altered the rush...
Well, I guess IV'ing diphenhydramine produces an enjoyable rush by itself. Monkeys will self administer it when given through this route.
Guessing this effect is purely additive.