Thanks for this, here's a few more of my assumptions if you care to comment on any one of them.
For ketamine - if anything I'd replace the Cl with a Br or I. Substitutions between these three halogens often yield compounds with similar activity (example 2c-b/c/i). Fluorine They aren't exactly the same, but are close. Also I'd say that the Cl plays an important part in achieving holes, with K-Holes being very easy to achieve.
MXE - I'd say that the PCE sets the overall binding affinities/potency/duration, the 3-meo slightly changes the binding affinities and makes the compound more likely to produce positive experiences (same as 3-meo-pcp vs pcp) and the 2-oxo lowers potency/duration to a more manageable level (compared to 3-meo-pce).
It's a shame the UK banned the entire class at least one vendor I know of was working on a bunch of arylcyclohexamines.
What's your opinion on compounds that don't look like ketamine/mxe/others drawn in 2d, but their 3d shapes are very similar? Worth exploring?
For ketamine - if anything I'd replace the Cl with a Br or I. Substitutions between these three halogens often yield compounds with similar activity (example 2c-b/c/i). Fluorine They aren't exactly the same, but are close. Also I'd say that the Cl plays an important part in achieving holes, with K-Holes being very easy to achieve.
MXE - I'd say that the PCE sets the overall binding affinities/potency/duration, the 3-meo slightly changes the binding affinities and makes the compound more likely to produce positive experiences (same as 3-meo-pcp vs pcp) and the 2-oxo lowers potency/duration to a more manageable level (compared to 3-meo-pce).
It's a shame the UK banned the entire class at least one vendor I know of was working on a bunch of arylcyclohexamines.
What's your opinion on compounds that don't look like ketamine/mxe/others drawn in 2d, but their 3d shapes are very similar? Worth exploring?