The biggest risk would be serotonin depletion and serotonin receptor downregulation, altough i beleive this can be prevented with keeping the doses as low as possible. MDAI isnt a neurotoxin so that wont be an issue.
But without chronic use, I don't think this would happen much. Takes a while for
real downregulation to happen. Short-term variants of it happen all the time.
man that sounds like a horrible week must have followed
It seems weird to me that you get such bad comedowns. MDMA doesn't make me suicidal, but if definitely leaves me tired and very nostalgic for the feeling again, to the point of some emotional pain. It just tends to make me de-value everything except the memory of it for a few days after. I still eat, sleep, shower, etc, but it seems like the drive to do so isn't there. Strangely psychologically addicting for the first couple days after, and then when I get back to normal I don't wanna do it again for as long as I remember the nostalgia.
But MDAI didn't do any of that. Couldn't tell I did a drug the night before. Didn't feel nearly as artificial as MDMA, and my thinking was clearer. I've told someone I loved them my first time on MDMA without really meaning it. Don't think I could ever do that on MDAI.
Eh, I guess everyone just reacts different ways?
Come to think of it though, has anyone tried this with other people present, and interacting with them? Seems like it might be a little too self-involving to make interactions any good.
I've had a low dose around people, but they were playing a game outside, which ended up being too physical for me on MDAI. It was good while I had the energy, but the effects were very subtle.
Edit: For those even thinking about using MAOI's, make sure you use
MAO-B selective drugs and doses only! Remember that the selective MAO-B drugs lose selectivity above a certain dose.