I've now taken 25mg and 35mg sublingually twice (this is the new UK batch, I don't really have an opioid tolerance at the moment). Neither time have I had particular problems with the tongue - it's not much fun but it feels to me bitter rather than caustic. Possibly larger doses would be more problematic - I imagine I'll find out.
Both times have been due to being in moderate abdominal pain and not wanting to wait for my prescribed Tramadol to kick in orally. Both times the pain was completely gone within about 15 mins (the first one was after consuming alcohol and etizolam, hence the higher dose the second time, although I had admittedly taken some diazepam earlier so perhaps it wasn't really necessary). Neither time was there particular euphoria, although I did perhaps feel slight contentment.
I also somewhat foolishly vaped some aMT about 3 hours after the 35mg dosage because I felt tired (had taken a lot of stimulants the previous evening and not really slept). I vaped around 30mg of aMT from that point onwards repeatedly ever 2-3 hours for the next 15 or so hours (vaping is an incredibly inefficient ROA but feels so lovely). Didn't seem to be any negative interactions or ill effects. But then I have no idea what the half-life of AH-7921 is or whether a significant amount was still in my system.
Update 2pm: Just SLed 55mg. At this dose it was somewhat painful for the first 10-15 minutes but whether it's actually corrosive I cannot say. I could also feel the blood supply in my mouth - my lips actually began pulsating and I was worried I was having an allergic reaction, but I don't think I was. After 20 mins feels pretty much OK. I might even feel quite pleasant, actually...
Right, OK, so yesterday I took 55mg sublingually around 2pm. I went to the pub, played a couple of games of pool, stretched a gin and tonic over around three hours and still felt very little, so took another 35mg sublingually around 3.5 hours later.
Immediately after this, I began to exhibit many of the signs of a slight opioid overdose: nausea, light-headedness, itchiness, drowsiness, shallow breathing, decreased heart rate (around 58 bpm). It was fairly unpleasant and I felt quite anxious as I realised that I have no idea of the dose response curve of AH-7921. It felt like it might be very steep.
I was conscious and made sure I was around people for the next few hours, as I continued to feel this way. Around midnight, I lay in my flatmate's bed as I felt I was about to go to sleep. He was watching a film in the room and I asked him to keep an eye on me.
I lay there for around 2 incredible hours while experiencing a generally very pleasant, quite hallucinogenic nod. I felt my body rise up out of the bed and start to fly around the room, which was pretty cool. I then felt a moment of terror as I seemed to fall a long way, and was convinced I could hear my flatmate making vaguely menacing remarks, although he assures me that he wasn't. There was no nausea durng this period.
This stopped after a while and I went to my own bed. I had the sort of typical, slightly opiated sleep where your skin feels really warm and you feel slightly more conscious during your dreams, which are all pretty enjoyable.
Don't think I'll be messing with this recreationally again. It does seem very effective as a painkiller at low doses but the dose required for a slight nod entailed far too many adverse symptoms for far too long for it to be worth it.
It's not THAT aggressive but still a bit harsh.
