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Dissociatives [Methoxetamine Subthread] Adverse Effects / Side-effects

Doctors are saying my kidneys haven't been getting any worse since I stopped these drugs. Of course, they're not getting any better either. It's obvious this is what damaged my kidneys to me.
All the doctors can do is monitor my kidneys and give me benazepril to help regulate the proteins that my kidneys are leaking for now. (Leaked proteins can be poisonous and make you sick or die)

The exact words of the renal clinic doctor was "You're lucky you didn't die and you're lucky your kidneys have stopped degrading. You have about 70% kidney function left and a normal person your age should have about 85%. Stop doing these drugs"

They're still trying to figure out why I'm having daily stomach pains. I just got insurance through my work now and have a big appointment later this month to try and diagnose that for sure..
I managed to get the scoping appointments moved up much closer.

They have been taking X-ray after X-ray and even CT scans etc of my chest and can't see why im having chest pains.

I wasn't in any pain, anywhere, before I found these crazy substances. Keep this in mind.

I insist the chest pains are related to the cardiac region and their surrounding veins.
I can't get doctors to understand that and me to the cardiologist yet, but I'm trying. The new insurance I can just schedule specialists as I please. But this is going to cost me thousands of dollars.

Ps..
My old account shows no posts. They were all deleted.
I find that incredible, considering they could have helped somebody in the long run and the mania spree I went on that was out of this world, but.. ..moving on.
I realize iwas also disrespectful, even though the ordeal I was going through was insane and still is.
 
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Ghost_of_EWO said:
the renal clinic doctor was "You're lucky you didn't die and you're lucky your kidneys have stopped degrading. You have about 70% kidney function left
Click to expand...

glad to read you again and get to know you are alive, despite all the shit life tends to throw up at us. have you been reading the mxe dandy thread? there's a guy called meowfish, you should read it, he might remind you that guy you see when you look in the mirror
 
EWO -- it might feel like you're not making progress, but that does sound like progress to me. wishing all the best for ya man.
 
Anyone had any experience of seizures or similar effects from MXE?

A friend of mine (really a friend, not me in disguise) got some K, thought it was cut with MXE (experienced K user). After a few sniffs ended up shooting some (IM I presume) and says she 'had a fit'. Not conclusive, I know, but I've had a scan through here and Erowid and can't find any reports of similar experiences.
Alternatively could just pinning K give you a fit?

No previous incidence of seizures, some amphetamine use a few hours previously.

edit: I should clarify, she described feeling waves of pain, stumbled about briefly, fell down convulsing, blacked out and experienced hallucinations that seemed like true experience (people stood in the doorway looking at her on the floor who weren't there etc.) and came round feeling shaky. Feeling weak and tired for a couple of days after.
 
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I had a huge panic attack on MXE. I made the mistake last night of taking a wee bit too much (and not laying down/putting on music.) It might have been a double dose taken accidentally (not sure though.) I use a scale but I might have dissolved 100mg, then dissolved another 100mg not realizing I'd already dissolved it. I thought it was a heart attack told someone to call an ambulance. I felt better in a couple of minutes and tried to cancel the ambulance but they came & forced me to go to the ER (threatening to call the police and baker act me if I didn't go, meaning 72 hours of observation in a facility and dealing with the cops.)

At the hospital they did an EKG to rule out a heart attack and sent me home after an hour. No other tests were done (other than vitals. They didn't even do a drug test) Now I'm going to get a huge ass bill. I guess after several years of MXE use something bad finally happened. I just told the doc to treat it as ketamine but he put unknown substance.

I have taken MXE probably almost 1000 times and got freaked out a couple of times. I don't actually remember the panic attack but once I realized that they were coming I quickly took 3 grams of piracetam. I think the reason they felt I was in danger is because I couldn't speak properly. By the time I got to the ER I was probably 80% better. I was told that since I had taken a drug I did not have the option of refusing medical treatment.

Time for a break I suppose. Be safe out there folks.
 
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Can anyone else, including THCified comment/ add more on the different batches of MXE?

I mean, got some stuff that i made last two years... which was perfect MXE. then new batch i got was fucking sub-par. it was fucking strong this stuff, it was way more dissiacative, it had all the MXE side-effects, but NO euphoria AT ALL and it lasted way too long to be MXE. plus the only RoA that worked was snorting. So be careful ppl, i think this is fuked.

I think there's some nasty shit out there, really.

hopefully one day i will find mxe again.
 
oar9fi said:
I had a huge panic attack on MXE. I made the mistake last night of taking a wee bit too much (and not laying down/putting on music.) It might have been a double dose taken accidentally (not sure though.) I use a scale but I might have dissolved 100mg, then dissolved another 100mg not realizing I'd already dissolved it. I thought it was a heart attack told someone to call an ambulance. I felt better in a couple of minutes and tried to cancel the ambulance but they came & forced me to go to the ER (threatening to call the police and baker act me if I didn't go, meaning 72 hours of observation in a facility and dealing with the cops.)
.
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I had a same kind of attack few weeks back when I was redosing MXE while having a flu. Called "911" but didn't mention anything about MXE, just about my heart racing and having difficulty breathing. I could also utter only one word at a time, even though I can speak fairly well (though mumbling and slurring) on even higher doses normally. Started feeling better during the phone call and told them I may not need an ambulance after all and I'm probably having only a panic attack, and we agreed on that.

Had an EKG for different reasons yesterday and the doc said my heart has clearly been under stress for some time, but nothing acute or particularly alarming. I have had somewhat high BP/pulse forever and the use of MXE and 3-MeO-PCP has definitely contributed to my BP sometimes going clearly a bit batshit lately but I've been sick also.

Having a break too myself. I'm happy.
 
It's now 1 year I consume MXE, I consumed something beetween 7 and 10g in the period, with these last 2 month being somewhat binge like/real addiction.
I've to admit I'm not that well psychollogically since at least 1 month... Less passionnated in life, feeling blah, a bit disconnected, less emotionnal, less confident... These problem annoy me and I really hope they are only temporary. But when you see problem from ppl who have used to much DXM get (another dissociative), it's not really sure my problem is only temporary. Fuck. This scare the shit out of myself. Do I have ruined my life ?

In this period I took too other drugs (4fa, methylone, 3mmc, 5apb, 4acoDMT...), but not in excess at all when not really occasionnally.

I stopped MXE 1 week ago and have really low chance to go back into it (neither other drugs) since I got a new job. I'll report back how the situation evolve.
 
You only stopped 1 week ago, your body and mind will need more time than that to readjust. Don't worry too much, you have barely begun to be sober. :)
 
80mg + IV overdose was the most frightening thing ever. I am traumatized from it. Didn't bring scale with me, was iv'ing in bathroom, didn't understand what happened until a few days later. Felt like I had a stoke / went retarded. One of the common visions was on me getting stuck inside my iphone . Severe confusion.

Happened too many times ... In the midst of 1g binges and doing a bit too much (and having to function) , would try to sober oneself up with big amounts of vitamin C, water ,noopept, anything to flush the system. Turned me into a human computer.

Strange thoughts like that wern't congruent like wanting to look for things inside solid objects, wanting to eat things that are not edible ...

Wacked the fuck out of my memory. Dear lord. Hopefully it'll come back. Coluracetam anyone?

Used to keep noopept on hand to bring me back if it got too much, but theres a point where no noopept will help at all.

The withdrawls from 3 months on and off of MXE and 3-meo-pcp were horrendous. I can't even begin. Stuck in a severe state of panic, not feeling safe, weakness...

Some protips : Don't take choline or any stimulants with MXE. Neurotoxic. Serotogenics and GABAmineragenics are neuroprotective under the NMDA spell. You can tell which your body prefers.

Absolutely BIZARRE, beautiful, deep revelations, but traumatic revelations at the same time. There is a mirror at the bottom of the rabbit hole.

Have experienced the "seizure" or lack of motor control on this. I remember losing motor function enough to have grabbed some plants very hard on my front porch with my left hand not conciously.

I think it gets to a point where choline is barely reaching the receptors. I say this because of the huge effects nicotine had on getting me out of that, and my crazy cravings for it when at a bad point.

"Some are made of ions and some are made of mind, but the ones made of ketamine, stutter often, and are blind." Terence Mckenna

-lenses
 
I am pretty keen on nutrients and nutraceuticals... From what information I have collected about dissociative and MXE effects, I have identified some nutrients that get depleted as a result of use of MXE (and other arylcyclohexamines ) Anyone who is suffering from after effects, please try these simple remedies:

1. B12 ! It is recommended for nitrous use, right ? Tingling in the fingers? Grab some B12 (methyl-b12 is the best)

2. B6 - I prefer P-5-P , which gets converted to B6. 50 mgs ... Too much can cause problems, so don't hyper-dose.

3.Inositol! The glutamate systems seems to be buffered by inositol. Too little can be bad. Take as much inositol as you want.

Simple, and safe.

Some other reccommendations:

Harmaloids - Harmine and harmaline . Small doses... 40mgs of the hcl salt of mixed harmaloids REALLY REALLY helped with MXE after-burnout... After heavy use, the only way I can explain how my vision was , was comparable to taking a small dose of the 2cX-nbomes - cheesy visuals, rainbowey over stimulated serotoniney feel. Felt terrible. Unsafe.

Harmaloids are amazing. In a nutshell, harmaloids increase the amount of glutamate receptors.I can't find the study at this moment, but they have been shown to upregulate the EAAT1 system. This is one of the glutamate handling systems. This is good because the supression of NMDA function causes an over expression of glutamate afterwards. This can lead to neurotoxicity(not able to metabolize glutamate as well), and general feeling terrible (over-sensitivity to pain, light, sound) .

MXE and other related compounds can change metabolism of aspartate metabolites and glutamate metabolites... Under regulation of these metabolites can lead to schizophrenia like symptoms... Would likely occur in chronic use.

I have found huge relief from harmaloids alone.

DHA / Omega 3's - MXE promotes massive neurogenisis. I found big improvements in fluidity and lucidity with DHA (around 900mgs) .

I believe the mechanism of action is between the NMDA inhibition and agonism of glutamate receptors (mGluR1 especially). From wikipedia

"It has been suggested that mGluRs may act as regulators of neurons' vulnerability to excitotoxicity (a deadly neurochemical process involving glutamate receptor overactivation) through their modulation of NMDARs, the receptor most involved in that process.[23] Excessive amounts of N-methyl-D-aspartate (NMDA), the selective specific agonist of NMDARs, has been found to cause more damage to neurons in the presence of group I mGluR agonists."

GABA-drugs (especially benzos) will be neuroprotective with dissociatives.

Things to avoid :

Stimulants!!!

Wonder why such bad experiences with stimulants and MXE? Stimulants activate glutamate receptors like crazy. Increase (acetyl)choline flow...

Choline! Indirect dopamine activation. May be okay for after use. But not when any MXE is in the system.

If you are having severe memory problems, coluracetam will really help.

Hope this dump of information is helpful to someone. If i could reccommend just one thing for MXE after-effect healing, it would be the harmaloids.

-lenses
 
no_id said:
It's now 1 year I consume MXE, I consumed something beetween 7 and 10g in the period, with these last 2 month being somewhat binge like/real addiction.
I've to admit I'm not that well psychollogically since at least 1 month... Less passionnated in life, feeling blah, a bit disconnected, less emotionnal, less confident... These problem annoy me and I really hope they are only temporary. But when you see problem from ppl who have used to much DXM get (another dissociative), it's not really sure my problem is only temporary. Fuck. This scare the shit out of myself. Do I have ruined my life ?

In this period I took too other drugs (4fa, methylone, 3mmc, 5apb, 4acoDMT...), but not in excess at all when not really occasionnally.

I stopped MXE 1 week ago and have really low chance to go back into it (neither other drugs) since I got a new job. I'll report back how the situation evolve.
Click to expand...

So it's no two weeks I didn't donsume any psychoactive drug and I'm in a far better place mentally, feeling 90% myself. Another week should resolve all the issue.
 
no_id said:
It's now 1 year I consume MXE, I consumed something beetween 7 and 10g in the period, with these last 2 month being somewhat binge like/real addiction.
I've to admit I'm not that well psychollogically since at least 1 month... Less passionnated in life, feeling blah, a bit disconnected, less emotionnal, less confident... These problem annoy me and I really hope they are only temporary. But when you see problem from ppl who have used to much DXM get (another dissociative), it's not really sure my problem is only temporary. Fuck. This scare the shit out of myself. Do I have ruined my life ?

In this period I took too other drugs (4fa, methylone, 3mmc, 5apb, 4acoDMT...), but not in excess at all when not really occasionnally.

I stopped MXE 1 week ago and have really low chance to go back into it (neither other drugs) since I got a new job. I'll report back how the situation evolve.
Click to expand...

So it's now two weeks I didn't donsume any psychoactive drug and I'm in a far better place mentally, feeling 90% myself. Another week should resolve all the issue. All go well in my new job as It programmer too, my mental capacity aren't affected. I'm not that fucked after 1 year of methylone/mxe/speed/ketamine/4fa/3mmc/medicinal opiates/4acoDMT use and abuse.

In 1 year I've consumed smth like :
codeine : smth like 5g
kratom : 500g
MXE : a bit more than 10g
3mmc : almost 10g
Methylone : 3g
4Fa : almost 10g
speed : ~5g
ketamine : 1g
4acoDMT : 200mg
n2o : a bit more than 10 charger packs
cannabis : beetween 20 and 30 joints
ethylphenidate : 1g
5apb : 300mg
4MEC : 200mg
various benzodiazepine : a handfull of time
 
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Great post lenses. I have been taking B12 and Q10 for some time, hopefully they have helped at least a bit. I've also taken vitamin D and magnesium + B6 whenever I have remembered to take them.

Anybody know how the brain will recover from chronic MXE use? I have definitely been exhibiting some "schizophrenia like symptoms" lenses mentioned as well as mania, I'm still having some kind of residual mania after stopping MXE and I'm worried if this will plummet me into severe depression or something else at some point.

I have a doctor's appointment in couple of days, hopefully getting my kidneys/bladder checked. My liver is ok. What I do know is I have a high BP and there's something wrong with my heart (had an EKG taken previously). More information to follow when I know more.
 
lenses said:
Harmaloids - Harmine and harmaline . Small doses... 40mgs of the hcl salt of mixed harmaloids REALLY REALLY helped with MXE after-burnout...
Click to expand...

I wonder if the beta-carbolines in coffee have a similar effect. I know I feel calmer having a cup or two after feeling cracked out from MXE abuse the night before. Are you not worried about the MAOI effects of harm(al)ine though, or does it not matter since you're only doing small doses?
 
I took about 180mg of 4-FA over a couple of doses last night. Towards the end I had a very minor headache and I felt not too great (from the comedown), so I took 15mg of MXE. It seemed to go alright, so I took 35mg more or a little more than that. I proceeded to have a weird MXE experience. It felt disconnected and random, I felt less connected to the experience and it was kinda strange. To top it off, the headache I had from the 4-FA turned into a very strange, super-concentrated headache, in the same spot that I had felt it from just the 4-FA, but much more intense. The headache persisted until I finally went to sleep, many hours later.

This morning I woke up feeling utterly run down, like extreme body weakness, unpleasantness, no headache fortunately but all day so far whenever I stand up I get a massive head rush and my vision gets all sparkly and white. I almost collapsed in the shower from it. It feels very weird and I don't know if it's just the 4-FA or if it's something to do with the combo. I feel like it's mostly from the combo because I did 4-FA a few times years ago, and I never remember there being many negative effects afterwards. Just thought I'd mention this. Solipsis told me he thought 4-FA and MXE might be a bad idea. Looks like he may have been right. It's hard to say because I also did drugs 3 days ina row (the 4-FA + MXE was the 3rd day), which I used to do all the time a few years back but I'm a little older now and not used to that either.
 
Xorkoth if you had read my 4fa+mxe combination report you would have not gone down that path! (It's not a good combo as it seems you have confirmed from your own experience) Sorry you had to experience it first-hand!
 
Ah bummer, I should have researched trip reports. Is that how it went for you too?

I notice today that I have visual distortion when I stare at stuff... I was staring at the ceiling while having a long phone conversation and all the imperfections appears to be gradually zooming out and twisting slightly.
 
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